(22 nodes) Diacylglycerol metabolic process network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PNPLA2	Patatin-like phospholipase domain-containing protein 2 isoform X1. (486 aa)
	GPAT4	PlsC domain-containing protein. (457 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (825 aa)
	DGKK	Diacylglycerol kinase. (1266 aa)
	DAGLA	Diacylglycerol lipase alpha. (1058 aa)
	DGKD	Diacylglycerol kinase. (1244 aa)
	DGKE	Diacylglycerol kinase. (566 aa)
	LOC100624333	Uncharacterized protein. (361 aa)
	DGKG	Diacylglycerol kinase. (791 aa)
	DGKZ	Diacylglycerol kinase. (1144 aa)
	MOGAT2	Monoacylglycerol O-acyltransferase 2. (337 aa)
	DGKI	Diacylglycerol kinase. (1110 aa)
	DGKA	Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (785 aa)
	LOC110259135	Uncharacterized protein. (340 aa)
	PLCE1	Phosphoinositide phospholipase C. (2316 aa)
	DGAT2	Uncharacterized protein. (339 aa)
	DGKB	Diacylglycerol kinase. (802 aa)
	LIPE	Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa)
	DGKQ	Diacylglycerol kinase. (987 aa)
	ANG	Ribonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family. (177 aa)
	APOA2	Apolipoprotein A-II preproprotein. (100 aa)
	DGAT1	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (665 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DGAT1	DGAT2	ENSSSCP00000073101	ENSSSCP00000051058	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Uncharacterized protein.	0.991
DGAT1	DGKA	ENSSSCP00000073101	ENSSSCP00000043702	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.	0.742
DGAT1	DGKB	ENSSSCP00000073101	ENSSSCP00000051186	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase.	0.689
DGAT1	DGKD	ENSSSCP00000073101	ENSSSCP00000017272	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase.	0.711
DGAT1	DGKE	ENSSSCP00000073101	ENSSSCP00000018670	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase.	0.689
DGAT1	DGKG	ENSSSCP00000073101	ENSSSCP00000024294	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase.	0.711
DGAT1	DGKI	ENSSSCP00000073101	ENSSSCP00000042409	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase.	0.650
DGAT1	DGKK	ENSSSCP00000073101	ENSSSCP00000013098	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase.	0.668
DGAT1	DGKQ	ENSSSCP00000073101	ENSSSCP00000063004	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase.	0.703
DGAT1	DGKZ	ENSSSCP00000073101	ENSSSCP00000037710	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Diacylglycerol kinase.	0.681
DGAT1	GPAM	ENSSSCP00000073101	ENSSSCP00000011325	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.	0.712
DGAT1	GPAT4	ENSSSCP00000073101	ENSSSCP00000007481	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	PlsC domain-containing protein.	0.719
DGAT1	LIPE	ENSSSCP00000073101	ENSSSCP00000054112	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.	0.695
DGAT1	LOC100624333	ENSSSCP00000073101	ENSSSCP00000022932	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Uncharacterized protein.	0.930
DGAT1	LOC110259135	ENSSSCP00000073101	ENSSSCP00000045162	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Uncharacterized protein.	0.929
DGAT1	MOGAT2	ENSSSCP00000073101	ENSSSCP00000041385	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Monoacylglycerol O-acyltransferase 2.	0.661
DGAT1	PNPLA2	ENSSSCP00000073101	ENSSSCP00000013651	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	Patatin-like phospholipase domain-containing protein 2 isoform X1.	0.957
DGAT2	DGAT1	ENSSSCP00000051058	ENSSSCP00000073101	Uncharacterized protein.	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	0.991
DGAT2	DGKA	ENSSSCP00000051058	ENSSSCP00000043702	Uncharacterized protein.	Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.	0.650
DGAT2	DGKB	ENSSSCP00000051058	ENSSSCP00000051186	Uncharacterized protein.	Diacylglycerol kinase.	0.661