STRINGSTRING
INPP5E INPP5E MTMR9 MTMR9 PLPP2 PLPP2 SYNJ2 SYNJ2 PLPPR1 PLPPR1 INPPL1 INPPL1 MTMR2 MTMR2 MTMR4 MTMR4 PLPP1 PLPP1 EPHX2 EPHX2 INPP5D INPP5D PLPPR3 PLPPR3 MTMR7 MTMR7 PLPPR5 PLPPR5 MTMR10 MTMR10 MTMR12 MTMR12 INPP5A INPP5A INPP5F INPP5F PTEN PTEN LOC100625564 LOC100625564 PLPPR4 PLPPR4 MTMR11 MTMR11 PIP4P2 PIP4P2 CCDC180 CCDC180 PLPP6 PLPP6 INPP5B INPP5B MTMR8 MTMR8 INPP5K INPP5K FIG4 FIG4 MTMR1 MTMR1 PSORS1C2 PSORS1C2 MTM1 MTM1 PIP4P1 PIP4P1 SYNJ1 SYNJ1 PLPP3 PLPP3 OCRL OCRL SGPP1 SGPP1 INPP5J INPP5J PLPP4 PLPP4 PLPPR2 PLPPR2 MTMR6 MTMR6 LOC106510645 LOC106510645 MTMR3 MTMR3 SACM1L SACM1L SGPP2 SGPP2 PLPP5 PLPP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INPP5EInositol polyphosphate-5-phosphatase E. (829 aa)
MTMR9Myotubularin related protein 9. (576 aa)
PLPP2Phospholipid phosphatase 2. (368 aa)
SYNJ2Synaptojanin 2. (1402 aa)
PLPPR1Phospholipid phosphatase related 1. (347 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] (1265 aa)
MTMR2Myotubularin-related protein 2 isoform 1. (643 aa)
MTMR4Myotubularin related protein 4. (1205 aa)
PLPP1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa)
EPHX2Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators. The N- terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12- phosphonooxy-octadec-9Z-enoic acid and 12-phosphon [...] (575 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
PLPPR3Phospholipid phosphatase-related protein type 3 isoform 2. (756 aa)
MTMR7Myotubularin related protein 7. (659 aa)
PLPPR5Phospholipid phosphatase related 5. (332 aa)
MTMR10Myotubularin-related protein 10. (766 aa)
MTMR12Myotubularin related protein 12. (746 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (472 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform 1. (1133 aa)
PTENUncharacterized protein. (576 aa)
LOC100625564Uncharacterized protein. (480 aa)
PLPPR4Phospholipid phosphatase-related protein type 4 isoform 1. (715 aa)
MTMR11Myotubularin phosphatase domain-containing protein. (700 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
CCDC180Coiled-coil domain containing 180. (1646 aa)
PLPP6Phospholipid phosphatase 6. (300 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (877 aa)
MTMR8Myotubularin-related protein 8. (692 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (480 aa)
FIG4FIG4 phosphoinositide 5-phosphatase. (915 aa)
MTMR1Myotubularin related protein 1. (671 aa)
PSORS1C2Psoriasis susceptibility 1 candidate 2. (135 aa)
MTM1Myotubularin isoform X3. (603 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
SYNJ1Synaptojanin 1. (1576 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (903 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (443 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1066 aa)
PLPP4Phospholipid phosphatase 4. (346 aa)
PLPPR2Phospholipid phosphatase related 2. (427 aa)
MTMR6Myotubularin related protein 6. (660 aa)
LOC106510645Myotubularin-related protein 9. (543 aa)
MTMR3Myotubularin related protein 3. (1215 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (596 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2 isoform a. (399 aa)
PLPP5Phospholipid phosphatase 5. (263 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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