38 items (Sus scrofa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HK2	Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa)
	ALKBH7	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial. (242 aa)
	TMEM102	Transmembrane protein 102. (495 aa)
	BBC3	Uncharacterized protein. (361 aa)
	A0A5G2QRP7_PIG	Uncharacterized protein. (104 aa)
	MPV17L	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (186 aa)
	ATP5IF1	ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron i [...] (108 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (850 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
	NOL3	Nucleolar protein 3. (237 aa)
	SLC25A6	ADP/ATP translocase 3, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity). (355 aa)
	BOK	BCL2 family apoptosis regulator BOK. (288 aa)
	BNIP3L	BCL2 interacting protein 3 like. (204 aa)
	BAD	BCL2 associated agonist of cell death. (209 aa)
	RHOT1	Ras homolog family member T1. (752 aa)
	A0A286ZWW0_PIG	AIG1-type G domain-containing protein. (321 aa)
	BCL2L1	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
	BAK1	Uncharacterized protein. (266 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa)
	SLC25A4	Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	TMEM14A	Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. (99 aa)
	GSK3A	Protein kinase domain-containing protein. (566 aa)
	BAX	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
	STPG1	Sperm tail PG-rich repeat containing 1. (335 aa)
	HEBP2	Uncharacterized protein. (368 aa)
	ACAA2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	PMAIP1	Uncharacterized protein. (121 aa)
	ZNF205	Zinc finger protein 205. (570 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (305 aa)
	BNIP3	BCL2 interacting protein 3. (202 aa)
	SLC25A5	Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (237 aa)
	VDAC2	Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules. (294 aa)
	HIP1R	Huntingtin-interacting protein 1-related protein isoform 1. (1068 aa)
	SLC25A31	Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
	SLC35F6	Solute carrier family 35 member F6; May play a role as a nucleotide-sugar transporter. (371 aa)
	BCL2L11	Uncharacterized protein. (433 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5G2QRP7_PIG	BCL2L1	ENSSSCP00000067595	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.406
A0A5G2QRP7_PIG	BNIP3L	ENSSSCP00000067595	ENSSSCP00000044058	Uncharacterized protein.	BCL2 interacting protein 3 like.	0.643
BAD	BAK1	ENSSSCP00000042395	ENSSSCP00000032742	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.805
BAD	BCL2L1	ENSSSCP00000042395	ENSSSCP00000033436	BCL2 associated agonist of cell death.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.998
BAD	BCL2L11	ENSSSCP00000042395	ENSSSCP00000008657	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.870
BAD	BOK	ENSSSCP00000042395	ENSSSCP00000044300	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.751
BAD	TP53	ENSSSCP00000042395	ENSSSCP00000050664	BCL2 associated agonist of cell death.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.408
BAK1	BAD	ENSSSCP00000032742	ENSSSCP00000042395	Uncharacterized protein.	BCL2 associated agonist of cell death.	0.805
BAK1	BAX	ENSSSCP00000032742	ENSSSCP00000003404	Uncharacterized protein.	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	0.901
BAK1	BBC3	ENSSSCP00000032742	ENSSSCP00000070559	Uncharacterized protein.	Uncharacterized protein.	0.768
BAK1	BCL2L1	ENSSSCP00000032742	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.998
BAK1	BCL2L11	ENSSSCP00000032742	ENSSSCP00000008657	Uncharacterized protein.	Uncharacterized protein.	0.896
BAK1	PMAIP1	ENSSSCP00000032742	ENSSSCP00000027713	Uncharacterized protein.	Uncharacterized protein.	0.659
BAK1	TP53	ENSSSCP00000032742	ENSSSCP00000050664	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.978
BAX	BAK1	ENSSSCP00000003404	ENSSSCP00000032742	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Uncharacterized protein.	0.901
BAX	BCL2L1	ENSSSCP00000003404	ENSSSCP00000033436	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.901
BAX	TP53	ENSSSCP00000003404	ENSSSCP00000050664	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.900
BAX	VDAC2	ENSSSCP00000003404	ENSSSCP00000011005	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules.	0.406
BBC3	BAK1	ENSSSCP00000070559	ENSSSCP00000032742	Uncharacterized protein.	Uncharacterized protein.	0.768
BBC3	BCL2L1	ENSSSCP00000070559	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.982