(21 nodes) Vascular endothelial growth factor receptor signaling pathway network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Predicted Interactions

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Your Input:
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	VEGFD	Vascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family. (354 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (361 aa)
	VEGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (465 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (924 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
	VEGFA	Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (887 aa)
	PDCD6	Programmed cell death 6. (292 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	CLEC14A	C-type lectin domain family 14 member A. (493 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (889 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
	FGF9	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
	DAB2IP	DAB2 interacting protein. (1196 aa)
	SULF1	Sulfatase 1. (1108 aa)
	HSPB1	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. (365 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	KDR	ENSSSCP00000050049	ENSSSCP00000029403	BCAR1 scaffold protein, Cas family member.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.512
BCAR1	PTK2B	ENSSSCP00000050049	ENSSSCP00000010320	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.971
BCAR1	VEGFA	ENSSSCP00000050049	ENSSSCP00000054926	BCAR1 scaffold protein, Cas family member.	Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...]	0.515
CLEC14A	FLT4	ENSSSCP00000021680	ENSSSCP00000014892	C-type lectin domain family 14 member A.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.471
FGF10	FGF18	ENSSSCP00000017886	ENSSSCP00000028172	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.545
FGF10	FGF9	ENSSSCP00000017886	ENSSSCP00000060438	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity).	0.529
FGF10	FLT1	ENSSSCP00000017886	ENSSSCP00000062931	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.776
FGF10	FLT4	ENSSSCP00000017886	ENSSSCP00000014892	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.752
FGF10	KDR	ENSSSCP00000017886	ENSSSCP00000029403	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.802
FGF10	VEGFA	ENSSSCP00000017886	ENSSSCP00000054926	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...]	0.439
FGF10	VEGFC	ENSSSCP00000017886	ENSSSCP00000016710	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.454
FGF18	FGF10	ENSSSCP00000028172	ENSSSCP00000017886	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.545
FGF18	FGF9	ENSSSCP00000028172	ENSSSCP00000060438	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity).	0.575
FGF18	FLT1	ENSSSCP00000028172	ENSSSCP00000062931	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.778
FGF18	FLT4	ENSSSCP00000028172	ENSSSCP00000014892	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.771
FGF18	KDR	ENSSSCP00000028172	ENSSSCP00000029403	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.799
FGF18	NRP1	ENSSSCP00000028172	ENSSSCP00000069067	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Neuropilin; Belongs to the neuropilin family.	0.411
FGF18	VEGFA	ENSSSCP00000028172	ENSSSCP00000054926	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...]	0.492
FGF18	VEGFC	ENSSSCP00000028172	ENSSSCP00000016710	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.451
FGF9	FGF10	ENSSSCP00000060438	ENSSSCP00000017886	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity).	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.529