STRINGSTRING
PTEN PTEN PLCZ1 PLCZ1 PPARD PPARD SERPINA12 SERPINA12 PIK3CD PIK3CD PIK3C3 PIK3C3 EZR EZR IGF1R IGF1R PEAR1 PEAR1 PI4KB PI4KB LOC100625564 LOC100625564 MYO16 MYO16 INPP5F INPP5F GPR143 GPR143 PLCB3 PLCB3 PDGFRB PDGFRB PIK3C2B PIK3C2B NYAP2 NYAP2 HTR2B HTR2B PLCD3 PLCD3 ERBB2 ERBB2 NF1 NF1 ERBB3 ERBB3 PLCD1 PLCD1 CSF2 CSF2 KBTBD2 KBTBD2 PRR5 PRR5 PIK3R1 PIK3R1 PIK3C2A PIK3C2A PIK3C2G PIK3C2G NYAP1 NYAP1 OGT OGT HTR2A HTR2A PIRT PIRT PIK3R5 PIK3R5 PREX2 PREX2 PI4KA PI4KA GPR143-2 GPR143-2 PLCB4 PLCB4 PLCL1 PLCL1 PITPNM2 PITPNM2 PLEKHA1 PLEKHA1 GATA3 GATA3 KCNH1 KCNH1 PLCH2 PLCH2 EDN1 EDN1 PRR5L PRR5L PIK3CG PIK3CG PLCE1 PLCE1 PDGFRA PDGFRA PTAFR PTAFR EXOC1 EXOC1 PLCL2 PLCL2 PIK3CB PIK3CB PIK3CA PIK3CA CA8 CA8 PLCH1 PLCH1 PLCB2 PLCB2 ZFP36L1 ZFP36L1 A0A5G2Q9W0_PIG A0A5G2Q9W0_PIG PIK3R2 PIK3R2 IRS1 IRS1 SIRT2 SIRT2 CSF1R CSF1R C1QBP C1QBP PLCB1 PLCB1 RPS6KB1 RPS6KB1 CD28 CD28 PITPNM3 PITPNM3 PLCD4 PLCD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTENUncharacterized protein. (576 aa)
PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (639 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1201 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa)
EZREzrin. (562 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1038 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (841 aa)
LOC100625564Uncharacterized protein. (480 aa)
MYO16Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (940 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform 1. (1133 aa)
GPR143Uncharacterized protein. (405 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
NYAP2Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2. (719 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (481 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
NF1Neurofibromin 1. (2847 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
PLCD1Phosphoinositide phospholipase C. (724 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
KBTBD2Kelch repeat and BTB domain-containing protein 2 isoform X1. (623 aa)
PRR5Proline rich 5. (386 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1511 aa)
NYAP1Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1. (840 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross- talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating [...] (1074 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (135 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein- mediated activation of PIK3CG. (878 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1614 aa)
PI4KAPhosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2072 aa)
GPR143-2Uncharacterized protein. (412 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCL1Phosphoinositide phospholipase C. (1096 aa)
PITPNM2Phosphatidylinositol transfer protein membrane associated 2. (1326 aa)
PLEKHA1Pleckstrin homology domain-containing family A member 1 isoform X3. (402 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
KCNH1Uncharacterized protein. (919 aa)
PLCH2Phosphoinositide phospholipase C. (1329 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
PRR5LProline rich 5 like. (473 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates [...] (1102 aa)
PLCE1Phosphoinositide phospholipase C. (2316 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
PTAFRPlatelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. May have a role in peri-implantation development during pregnancy (By similarity); Belongs to the G-protein coupled receptor 1 family. (402 aa)
EXOC1Exocyst complex component 1. (927 aa)
PLCL2Phosphoinositide phospholipase C. (1128 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CA8Carbonic anhydrase 8; Belongs to the alpha-carbonic anhydrase family. (291 aa)
PLCH1Phosphoinositide phospholipase C. (1690 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ZFP36L1ZFP36 ring finger protein like 1. (348 aa)
A0A5G2Q9W0_PIGG_PROTEIN_RECEP_F1_2 domain-containing protein. (367 aa)
PIK3R2Uncharacterized protein. (772 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa)
CSF1RColony stimulating factor 1 receptor. (1053 aa)
C1QBPMitochondrial complement component 1 Q subcomponent-binding protein. (281 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CD28IGv domain-containing protein. (222 aa)
PITPNM3PITPNM family member 3. (1730 aa)
PLCD41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (797 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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