(23 nodes) Inositol phosphate-mediated signaling network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPR62	G protein-coupled receptor 62. (363 aa)
	NMUR1	Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family. (556 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (840 aa)
	NFATC3	Nuclear factor of activated T cells 3. (1149 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (527 aa)
	NFAT5	Nuclear factor of activated T cells 5. (1550 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2. (916 aa)
	EDN2	Endothelin 2. (180 aa)
	ADGRB2	Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1581 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. (938 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
	TBC1D10C	TBC1 domain family member 10C. (458 aa)
	PPP3R1	Uncharacterized protein. (188 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
	MIOX	Inositol oxygenase. (320 aa)
	NFATC4	Nuclear factor of activated T cells 4. (937 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (523 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (472 aa)
	RCAN1	Regulator of calcineurin 1. (249 aa)
	NMUR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (410 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRB2	GPR62	ENSSSCP00000039903	ENSSSCP00000067808	Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family.	G protein-coupled receptor 62.	0.408
EDN1	EDN2	ENSSSCP00000043269	ENSSSCP00000038265	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin 2.	0.921
EDN1	NMUR1	ENSSSCP00000043269	ENSSSCP00000071631	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.557
EDN1	NMUR2	ENSSSCP00000043269	ENSSSCP00000018092	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.602
EDN2	EDN1	ENSSSCP00000038265	ENSSSCP00000043269	Endothelin 2.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.921
EDN2	NMUR1	ENSSSCP00000038265	ENSSSCP00000071631	Endothelin 2.	Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.499
EDN2	NMUR2	ENSSSCP00000038265	ENSSSCP00000018092	Endothelin 2.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.502
GPR62	ADGRB2	ENSSSCP00000067808	ENSSSCP00000039903	G protein-coupled receptor 62.	Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family.	0.408
ITPR1	ITPR2	ENSSSCP00000064275	ENSSSCP00000026062	Inositol 1,4,5-trisphosphate receptor type 1.	Inositol 1,4,5-trisphosphate receptor type 2.	0.920
ITPR1	ITPR3	ENSSSCP00000064275	ENSSSCP00000056763	Inositol 1,4,5-trisphosphate receptor type 1.	Inositol 1,4,5-trisphosphate receptor type 3.	0.921
ITPR2	ITPR1	ENSSSCP00000026062	ENSSSCP00000064275	Inositol 1,4,5-trisphosphate receptor type 2.	Inositol 1,4,5-trisphosphate receptor type 1.	0.920
ITPR2	ITPR3	ENSSSCP00000026062	ENSSSCP00000056763	Inositol 1,4,5-trisphosphate receptor type 2.	Inositol 1,4,5-trisphosphate receptor type 3.	0.901
ITPR3	ITPR1	ENSSSCP00000056763	ENSSSCP00000064275	Inositol 1,4,5-trisphosphate receptor type 3.	Inositol 1,4,5-trisphosphate receptor type 1.	0.921
ITPR3	ITPR2	ENSSSCP00000056763	ENSSSCP00000026062	Inositol 1,4,5-trisphosphate receptor type 3.	Inositol 1,4,5-trisphosphate receptor type 2.	0.901
NFATC1	NFATC2	ENSSSCP00000040717	ENSSSCP00000029783	Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2.	0.937
NFATC1	NFATC3	ENSSSCP00000040717	ENSSSCP00000021956	Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.	Nuclear factor of activated T cells 3.	0.924
NFATC1	PPP3CA	ENSSSCP00000040717	ENSSSCP00000009781	Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.	Serine/threonine-protein phosphatase.	0.977
NFATC1	PPP3CB	ENSSSCP00000040717	ENSSSCP00000029235	Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.	Serine/threonine-protein phosphatase.	0.961
NFATC1	PPP3R1	ENSSSCP00000040717	ENSSSCP00000060552	Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.	Uncharacterized protein.	0.984
NFATC1	RCAN1	ENSSSCP00000040717	ENSSSCP00000012831	Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.	Regulator of calcineurin 1.	0.401