(25 nodes) Sperm capacitation network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	CABYR	RIIa domain-containing protein. (469 aa)
	ACRBP	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. (539 aa)
	SLC26A8	Solute carrier family 26 member 8. (1188 aa)
	BSP1	Seminal plasma protein pB1; May form a complex with spermadhesin AQN-1 which possesses phosphorylcholine-binding activity. (152 aa)
	BSPH1	Binder of sperm protein homolog 1. (127 aa)
	ELSPBP1	Epididymal sperm-binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity. (223 aa)
	CATSPERZ	Uncharacterized protein. (289 aa)
	CATSPERD	Cation channel sperm associated auxiliary subunit delta. (790 aa)
	EFCAB9	Uncharacterized protein. (328 aa)
	IQCF1	IQ motif containing F1. (207 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	ROPN1L	Rhophilin associated tail protein 1 like. (218 aa)
	SLC26A3	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (759 aa)
	IQCF5	IQ motif containing F5. (149 aa)
	DEFB1-2	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (64 aa)
	CATSPER3	Ion_trans domain-containing protein. (425 aa)
	ROPN1	Ropporin-1B isoform X1. (212 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (834 aa)
	CATSPER4	Cation channel sperm associated 4. (471 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa)
	ABHD2	Abhydrolase domain containing 2. (453 aa)
	SLC26A6	Solute carrier family 26 member 6. (753 aa)
	CATSPER2	Cation channel sperm associated 2. (538 aa)
	SPINK1	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). (79 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD2	CATSPER2	ENSSSCP00000039564	ENSSSCP00000057106	Abhydrolase domain containing 2.	Cation channel sperm associated 2.	0.508
ABHD2	CATSPER3	ENSSSCP00000039564	ENSSSCP00000025936	Abhydrolase domain containing 2.	Ion_trans domain-containing protein.	0.602
ABHD2	CATSPER4	ENSSSCP00000039564	ENSSSCP00000028118	Abhydrolase domain containing 2.	Cation channel sperm associated 4.	0.581
ACRBP	BSP1	ENSSSCP00000000746	ENSSSCP00000003307	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Seminal plasma protein pB1; May form a complex with spermadhesin AQN-1 which possesses phosphorylcholine-binding activity.	0.419
ACRBP	ELSPBP1	ENSSSCP00000000746	ENSSSCP00000003383	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Epididymal sperm-binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity.	0.453
ACRBP	ROPN1	ENSSSCP00000000746	ENSSSCP00000027248	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Ropporin-1B isoform X1.	0.535
BSP1	ACRBP	ENSSSCP00000003307	ENSSSCP00000000746	Seminal plasma protein pB1; May form a complex with spermadhesin AQN-1 which possesses phosphorylcholine-binding activity.	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	0.419
CABYR	CATSPER2	ENSSSCP00000065850	ENSSSCP00000057106	RIIa domain-containing protein.	Cation channel sperm associated 2.	0.415
CABYR	CATSPER4	ENSSSCP00000065850	ENSSSCP00000028118	RIIa domain-containing protein.	Cation channel sperm associated 4.	0.629
CABYR	ROPN1	ENSSSCP00000065850	ENSSSCP00000027248	RIIa domain-containing protein.	Ropporin-1B isoform X1.	0.811
CABYR	ROPN1L	ENSSSCP00000065850	ENSSSCP00000022077	RIIa domain-containing protein.	Rhophilin associated tail protein 1 like.	0.602
CABYR	SLC26A8	ENSSSCP00000065850	ENSSSCP00000001689	RIIa domain-containing protein.	Solute carrier family 26 member 8.	0.487
CATSPER2	ABHD2	ENSSSCP00000057106	ENSSSCP00000039564	Cation channel sperm associated 2.	Abhydrolase domain containing 2.	0.508
CATSPER2	CABYR	ENSSSCP00000057106	ENSSSCP00000065850	Cation channel sperm associated 2.	RIIa domain-containing protein.	0.415
CATSPER2	CATSPER3	ENSSSCP00000057106	ENSSSCP00000025936	Cation channel sperm associated 2.	Ion_trans domain-containing protein.	0.952
CATSPER2	CATSPER4	ENSSSCP00000057106	ENSSSCP00000028118	Cation channel sperm associated 2.	Cation channel sperm associated 4.	0.929
CATSPER2	CATSPERD	ENSSSCP00000057106	ENSSSCP00000014374	Cation channel sperm associated 2.	Cation channel sperm associated auxiliary subunit delta.	0.935
CATSPER2	CATSPERZ	ENSSSCP00000057106	ENSSSCP00000013854	Cation channel sperm associated 2.	Uncharacterized protein.	0.832
CATSPER2	EFCAB9	ENSSSCP00000057106	ENSSSCP00000018007	Cation channel sperm associated 2.	Uncharacterized protein.	0.937
CATSPER3	ABHD2	ENSSSCP00000025936	ENSSSCP00000039564	Ion_trans domain-containing protein.	Abhydrolase domain containing 2.	0.602