STRINGSTRING
ATXN1L ATXN1L TCF21 TCF21 NKX2-1 NKX2-1 LTBP3 LTBP3 RC3H2 RC3H2 SELENON SELENON IGFBP5 IGFBP5 SLC7A11 SLC7A11 KDR KDR STRA6 STRA6 MAN2A1 MAN2A1 GATA6 GATA6 BMPR2 BMPR2 ADA ADA MYOCD MYOCD SFTPD SFTPD ABCA12 ABCA12 BMP4 BMP4 MAN1A2 MAN1A2 ASXL1 ASXL1 PKDCC PKDCC HOXA5 HOXA5 FGF10 FGF10 NKIRAS2 NKIRAS2 HS6ST1 HS6ST1 PHF14 PHF14 TGFB1 TGFB1 STK40 STK40 TMEM38B TMEM38B CREB1 CREB1 LIF LIF EDN2 EDN2 ERRFI1 ERRFI1 NKIRAS1 NKIRAS1 FOXF1 FOXF1 FOXA1 FOXA1 CIC CIC SMPD3 SMPD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATXN1LAtaxin 1 like. (688 aa)
TCF21Transcription factor 21. (179 aa)
NKX2-1NK2 homeobox 1. (399 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
RC3H2Ring finger and CCCH-type domains 2. (1192 aa)
SELENONSelenoprotein N. (556 aa)
IGFBP5Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (271 aa)
SLC7A11Solute carrier family 7 member 11. (515 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
STRA6Stimulated by retinoic acid 6. (666 aa)
MAN2A1Alpha-mannosidase. (1164 aa)
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
ADAAdenosine deaminase. (409 aa)
MYOCDMyocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa)
SFTPDPulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. (386 aa)
ABCA12ATP binding cassette subfamily A member 12. (2593 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (677 aa)
ASXL1ASXL transcriptional regulator 1. (1542 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
HOXA5Homeobox domain-containing protein. (381 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a. (191 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
PHF14PHD finger protein 14. (953 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
STK40Serine/threonine-protein kinase 40 isoform 2. (435 aa)
TMEM38BTrimeric intracellular cation channel type B. (290 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
LIFLeukemia inhibitory factor isoform X1. (202 aa)
EDN2Endothelin 2. (180 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (461 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa)
FOXF1Forkhead box protein F1. (423 aa)
FOXA1Forkhead box A1. (468 aa)
CICCapicua transcriptional repressor. (2520 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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