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| | PPARA | Uncharacterized protein. (469 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | NDUFA9 | NADH:ubiquinone oxidoreductase subunit A9. (407 aa) |
| | HCRTR2 | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. (444 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (346 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | DBP | D-box binding PAR bZIP transcription factor. (325 aa) |
| | ATF5 | Activating transcription factor 5. (282 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa) |
| | KIAA2013 | KIAA2013. (647 aa) |
| | NR0B2 | Nuclear receptor subfamily 0 group B member 2. (260 aa) |
| | FOXO3 | Forkhead box protein O3 isoform X1. (672 aa) |
| | RORA | RAR related orphan receptor A. (530 aa) |
| | TYRO3 | TYRO3 protein tyrosine kinase. (913 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | SETX | Senataxin. (2676 aa) |
| | KLF10 | Kruppel-like factor 10. (480 aa) |
| | NHLH1 | Nescient helix-loop-helix 1. (133 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (795 aa) |
| | CIART | Circadian-associated transcriptional repressor isoform a. (453 aa) |
| | NHLH2 | Nescient helix-loop-helix 2. (135 aa) |
| | KDM8 | JmjC domain-containing protein 5 isoform 1. (406 aa) |
| | CREBBP | CREB-binding protein isoform a. (2440 aa) |
| | NPAS2 | Neuronal PAS domain protein 2. (796 aa) |
| | LHCGR | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa) |
| | ID2 | DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa) |
| | SLIT2 | Slit guidance ligand 2. (1542 aa) |
| | AFP | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin; Belongs to the ALB/AFP/VDB family. (610 aa) |
| | MTTP | Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (894 aa) |
| | HNRNPD | Heterogeneous nuclear ribonucleoprotein D0 isoform a. (355 aa) |
| | MYCBP2 | MYC binding protein 2. (4640 aa) |
| | NFIL3 | Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (411 aa) |
| | KDM5B | Lysine-specific demethylase 5B isoform 2. (1547 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (446 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa) |
| | PTX3 | Pentraxin-related protein PTX3. (382 aa) |
| | MAGED1 | Melanoma-associated antigen D1; Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl- conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression [...] (835 aa) |
| | HUWE1 | HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4415 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1139 aa) |
| | CRY2 | Cryptochrome circadian regulator 2. (615 aa) |
| | FSHB | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa) |
| | LGR4 | Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | NUDT12 | Nudix hydrolase 12. (472 aa) |
| | FBXL21P | F-box domain-containing protein. (420 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa) |
| | CCDC90B | Coiled-coil domain-containing protein 90B, mitochondrial isoform 1. (254 aa) |
| | PTPRN | Protein tyrosine phosphatase receptor type N. (978 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa) |
| | CARTPT | Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. Belongs to the CART family. (116 aa) |
| | SLIT3 | Slit guidance ligand 3. (1523 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | TOP2A | DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. (1531 aa) |
| | NGFR | Nerve growth factor receptor. (414 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (315 aa) |
| | HES7 | Hes family bHLH transcription factor 7. (225 aa) |
| | CDK5 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa) |
| | TNFAIP6 | Uncharacterized protein. (277 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | ID4 | DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). (161 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa) |
| | AHR | Aryl hydrocarbon receptor. (849 aa) |
| | ATOH7 | Atonal bHLH transcription factor 7. (155 aa) |
| | PROK2 | Prokineticin 2. (129 aa) |
| | RACK1 | Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (By similarity). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to [...] (317 aa) |
| | THRAP3 | Thyroid hormone receptor-associated protein 3 isoform 1. (958 aa) |
| | BMPR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | GAS2 | Growth arrest specific 2. (325 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) |
| | NR1D2 | Uncharacterized protein. (609 aa) |
| | NOCT | Nocturnin. (427 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa) |
| | PER3 | PAS domain-containing protein. (376 aa) |
| | OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross- talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating [...] (1074 aa) |
| | PER1 | Period circadian regulator 1. (1278 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (629 aa) |
| | DHX9 | ATP-dependent RNA helicase A. (1384 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (473 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | GPR176 | G-protein coupled receptor 176 isoform X1. (515 aa) |
| | PROKR2 | Prokineticin receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa) |
| | ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X3. (1006 aa) |
| | ARNTL2 | Aryl hydrocarbon receptor nuclear translocator like 2. (652 aa) |
| | PSPC1 | Paraspeckle component 1 isoform 1. (521 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa) |
| | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa) |
| | CRY1 | Cryptochrome circadian regulator 1. (588 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (574 aa) |
| | GFPT1 | Glutamine--fructose-6-phosphate transaminase 1. (704 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U isoform a. (825 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | MYBBP1A | MYB binding protein 1a. (1594 aa) |
| | SP1 | Transcription factor Sp1 isoform a. (786 aa) |
| | LOC100523244 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa) |
| | SCAPER | S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1. (1408 aa) |
| | SFPQ | Splicing factor, proline-and glutamine-rich isoform X1. (702 aa) |
| | A0A287A514_PIG | NR LBD domain-containing protein. (88 aa) |
| | C3orf70 | Chromosome 3 open reading frame 70. (250 aa) |
| | CLOCK | Clock circadian regulator. (857 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | ID1 | Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (154 aa) |
| | RAI1 | Retinoic acid induced 1. (2082 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (670 aa) |
| | PTN | Pleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa) |
| | ASS1 | Argininosuccinate synthase 1. (428 aa) |
| | AXL | Uncharacterized protein. (871 aa) |
| | PLEKHA1 | Pleckstrin homology domain-containing family A member 1 isoform X3. (402 aa) |
| | GPR149 | G protein-coupled receptor 149. (745 aa) |
| | GPR157 | G protein-coupled receptor 157. (334 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1463 aa) |
| | NAMPT | Nicotinamide phosphoribosyltransferase; Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock fun [...] (524 aa) |
| | RBM4B | RNA-binding protein 4B; Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). (369 aa) |
| | DYRK1A | Dual specificity tyrosine phosphorylation regulated kinase 1A. (764 aa) |
| | KMT2A | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4000 aa) |
| | CDK1 | Cyclin-dependent kinase 1 isoform 1; Belongs to the protein kinase superfamily. (297 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | NR5A1 | Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidy [...] (461 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | BHLHE41 | Class E basic helix-loop-helix protein 41. (482 aa) |
| | KLF9 | Krueppel-like factor 9; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation; Belongs to the Sp1 C2H2-type zinc-finger protein family. (334 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (389 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (462 aa) |
| | AANAT | Aralkylamine N-acetyltransferase. (275 aa) |
| | INHBA | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa) |
| | ARNTL | Aryl hydrocarbon receptor nuclear translocator like. (633 aa) |
| | BTBD9 | BTB domain containing 9. (612 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | MTNR1A | Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | ID3 | BHLH domain-containing protein. (118 aa) |
| | ENOX2 | Ecto-NOX disulfide-thiol exchanger 2. (550 aa) |
| | ENOX1 | Ecto-NOX disulfide-thiol exchanger 1. (762 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (609 aa) |
| | KDM2A | Lysine demethylase 2A. (1164 aa) |
| | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa) |
| | NONO | Non-POU domain containing octamer binding. (705 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa) |
| | ATF4 | Activating transcription factor 4. (329 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1195 aa) |
| | PER2 | Period circadian regulator 2. (1362 aa) |
| | BHLHE40 | Basic helix-loop-helix family member e40. (415 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | ROCK2 | Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (369 aa) |
| | MAPK9 | Mitogen-activated protein kinase 9. (461 aa) |
| | NRIP1 | Nuclear receptor-interacting protein 1 isoform X1. (1156 aa) |
| | A0A5G2QED1_PIG | Period_C domain-containing protein. (481 aa) |
| | ZNF830 | Zinc finger protein 830. (367 aa) |
| | NAGLU | N-acetyl-alpha-glucosaminidase. (744 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa) |
| | ZPBP2 | Zona pellucida binding protein 2. (363 aa) |
| | A0A5G2R9S5_PIG | SCHIP-1 domain-containing protein. (485 aa) |
| | HTR7 | 5-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (475 aa) |
| | LINC01862 | Long intergenic non-protein coding RNA 1862. (286 aa) |
| | CAVIN3 | Caveolae associated protein 3. (290 aa) |
| | ADAMTS1 | Peptidase M12B domain-containing protein. (963 aa) |
| | CSNK1D | Casein kinase 1 delta. (459 aa) |
