STRINGSTRING
AGR2 AGR2 SMAD3 SMAD3 HLX HLX ACVR2B ACVR2B TP63 TP63 PERCC1 PERCC1 AHI1 AHI1 NIPBL NIPBL TCF21 TCF21 HIF1A HIF1A NOTCH1 NOTCH1 PDGFRA PDGFRA STRA6 STRA6 BMP4 BMP4 SOX17 SOX17 SIX2 SIX2 ID2 ID2 SFRP2 SFRP2 NKX2-3 NKX2-3 EPHB3 EPHB3 IHH IHH SHH SHH GLI3 GLI3 FGF10 FGF10 WNT11 WNT11 SHOX2 SHOX2 SFRP1 SFRP1 CTNNB1 CTNNB1 SOX10 SOX10 EPB41L5 EPB41L5 WNT5A WNT5A FOXF1 FOXF1 NODAL NODAL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGR2Anterior gradient 2, protein disulphide isomerase family member. (206 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
HLXH2.0 like homeobox. (556 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PERCC1Uncharacterized protein. (280 aa)
AHI1Abelson helper integration site 1. (1114 aa)
NIPBLNipped-B protein. (2804 aa)
TCF21Transcription factor 21. (179 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
STRA6Stimulated by retinoic acid 6. (666 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SOX17SRY-box transcription factor 17. (407 aa)
SIX2SIX homeobox 2. (296 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
SFRP2Uncharacterized protein. (294 aa)
NKX2-3NK2 homeobox 3. (367 aa)
EPHB3Ephrin type-B receptor 3. (999 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
GLI3GLI family zinc finger 3. (1586 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
SHOX2Short stature homeobox 2. (321 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
CTNNB1Catenin beta 1. (808 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FOXF1Forkhead box protein F1. (423 aa)
NODALNodal growth differentiation factor. (316 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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