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PDGFRA PDGFRA STRA6 STRA6 FOXL1 FOXL1 DNAAF1 DNAAF1 SALL1 SALL1 MEGF8 MEGF8 GATA6 GATA6 BMP4 BMP4 FOXE1 FOXE1 EXT1 EXT1 SOX17 SOX17 GATA5 GATA5 SIX2 SIX2 PKDCC PKDCC ID2 ID2 CXCL8 CXCL8 SFRP2 SFRP2 CDX2 CDX2 RB1 RB1 EDNRB EDNRB CRKL CRKL NKX2-3 NKX2-3 CLDN18 CLDN18 CCDC39 CCDC39 EPHB3 EPHB3 ZIC3 ZIC3 LGR4 LGR4 F1SF13_PIG F1SF13_PIG FZD5 FZD5 IHH IHH SHH SHH SMO SMO HOXA5 HOXA5 GLI3 GLI3 FGF10 FGF10 SOX9 SOX9 CCDC103 CCDC103 WNT11 WNT11 SHOX2 SHOX2 CCDC40 CCDC40 TIGAR TIGAR TBX2 TBX2 PDGFC PDGFC MIXL1 MIXL1 DCHS1 DCHS1 GATA4 GATA4 YIPF6 YIPF6 SFRP1 SFRP1 SRC SRC IL6ST IL6ST SAV1 SAV1 CTNNB1 CTNNB1 YAP1 YAP1 COL3A1 COL3A1 TGFB2 TGFB2 NKX3-2 NKX3-2 SOX10 SOX10 CHD8 CHD8 PTK6 PTK6 EPB41L5 EPB41L5 ALX4 ALX4 WNT5A WNT5A NKX2-6 NKX2-6 FOXF1 FOXF1 A0A287AIY2_PIG A0A287AIY2_PIG AGR2 AGR2 KLF5 KLF5 HES1 HES1 NODAL NODAL KCNQ1 KCNQ1 SPDEF SPDEF NOTCH1 NOTCH1 HIF1A HIF1A RARRES2 RARRES2 TCF21 TCF21 PDX1 PDX1 NKX2-2 NKX2-2 FOXF2 FOXF2 NPHP3 NPHP3 NIPBL NIPBL PCSK5 PCSK5 PRDM1 PRDM1 AHI1 AHI1 VPS52 VPS52 FGF9 FGF9 PERCC1 PERCC1 PKD1 PKD1 TP63 TP63 KIT KIT CLMP CLMP ACVR2B ACVR2B MYOCD MYOCD ADA ADA C1GALT1 C1GALT1 HLX HLX SMAD3 SMAD3 ALDH1A2 ALDH1A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
STRA6Stimulated by retinoic acid 6. (666 aa)
FOXL1Forkhead box protein L1. (338 aa)
DNAAF1Dynein assembly factor 1, axonemal. (650 aa)
SALL1Spalt like transcription factor 1. (1326 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FOXE1Forkhead box E1. (373 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SOX17SRY-box transcription factor 17. (407 aa)
GATA5GATA binding protein 5. (393 aa)
SIX2SIX homeobox 2. (296 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
SFRP2Uncharacterized protein. (294 aa)
CDX2Homeobox domain-containing protein. (310 aa)
RB1RB transcriptional corepressor 1. (938 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
NKX2-3NK2 homeobox 3. (367 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
CCDC39Coiled-coil domain-containing protein 39. (942 aa)
EPHB3Ephrin type-B receptor 3. (999 aa)
ZIC3Zic family member 3. (467 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
F1SF13_PIGCobl domain-containing protein. (406 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
HOXA5Homeobox domain-containing protein. (381 aa)
GLI3GLI family zinc finger 3. (1586 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
CCDC103Dynein_attach_N domain-containing protein. (99 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
SHOX2Short stature homeobox 2. (321 aa)
CCDC40Coiled-coil domain containing 40. (986 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
TBX2T-box 2 protein. (714 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
MIXL1Mix paired-like homeobox. (237 aa)
DCHS1Dachsous cadherin-related 1. (3294 aa)
GATA4Transcription factor GATA-4 isoform 2. (442 aa)
YIPF6Protein YIPF. (235 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SRCTyrosine-protein kinase. (559 aa)
IL6STInterleukin 6 signal transducer. (938 aa)
SAV1Salvador family WW domain containing protein 1. (433 aa)
CTNNB1Catenin beta 1. (808 aa)
YAP1Yes associated protein 1. (432 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
NKX3-2NK3 homeobox 2. (337 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
PTK6Tyrosine-protein kinase. (449 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
ALX4ALX homeobox 4. (406 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NKX2-6NK2 homeobox 6. (299 aa)
FOXF1Forkhead box protein F1. (423 aa)
A0A287AIY2_PIGGlycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (260 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (206 aa)
KLF5Uncharacterized protein. (457 aa)
HES1Uncharacterized protein. (280 aa)
NODALNodal growth differentiation factor. (316 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (771 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (363 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
RARRES2Retinoic acid receptor responder 2. (177 aa)
TCF21Transcription factor 21. (179 aa)
PDX1Homeobox domain-containing protein. (284 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
FOXF2Forkhead box F2. (443 aa)
NPHP3TPR_REGION domain-containing protein. (1368 aa)
NIPBLNipped-B protein. (2804 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1886 aa)
PRDM1PR/SET domain 1. (842 aa)
AHI1Abelson helper integration site 1. (1114 aa)
VPS52VPS52 subunit of GARP complex. (725 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
PERCC1Uncharacterized protein. (280 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4383 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
CLMPCXADR like membrane protein. (399 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
MYOCDMyocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa)
ADAAdenosine deaminase. (409 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (367 aa)
HLXH2.0 like homeobox. (556 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (527 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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