STRINGSTRING
AQP1 AQP1 THRB THRB PAX6 PAX6 TTN TTN AHI1 AHI1 ATF4 ATF4 MFN2 MFN2 BCAR3 BCAR3 TTC8 TTC8 SOX8 SOX8 RDH13 RDH13 LOC110258874 LOC110258874 C12orf57 C12orf57 PTPRM PTPRM TFAP2B TFAP2B TBC1D20 TBC1D20 NTRK2 NTRK2 MEIS1 MEIS1 MEGF11 MEGF11 COL8A2 COL8A2 MYPN MYPN TH TH NOTCH1 NOTCH1 PROM1 PROM1 PITX2 PITX2 THY1 THY1 HIF1A HIF1A ROM1 ROM1 PROX1 PROX1 TFAP2A TFAP2A FRS2 FRS2 FOXF2 FOXF2 TSPAN12 TSPAN12 RPGRIP1 RPGRIP1 BAX BAX EPHA2 EPHA2 EPHB2 EPHB2 RPE65 RPE65 FOXE3 FOXE3 CITED2 CITED2 LCTL LCTL BMP4 BMP4 CRB2 CRB2 CALB1 CALB1 NOTCH2 NOTCH2 HIPK1 HIPK1 GNAT2 GNAT2 JAG1 JAG1 BMP7 BMP7 KDM2B KDM2B FOXN4 FOXN4 NF2 NF2 PDE6C PDE6C PITX3 PITX3 CRB1 CRB1 VHL VHL DSCAM DSCAM LRP5 LRP5 USH1C USH1C SP3 SP3 FZD5 FZD5 IHH IHH GLI3 GLI3 SOX9 SOX9 STAT3 STAT3 NF1 NF1 FJX1 FJX1 TBX2 TBX2 EPHB1 EPHB1 HCN1 HCN1 NRL NRL STRA6 STRA6 RING1 RING1 GDF11 GDF11 AQP5 AQP5 CTNNB1 CTNNB1 IMPG2 IMPG2 RPGRIP1L RPGRIP1L BAK1 BAK1 LHX1 LHX1 YY1 YY1 RS1 RS1 KDR KDR ZEB1 ZEB1 IGFN1 IGFN1 DLL1 DLL1 PTF1A PTF1A HIPK2 HIPK2 CDON CDON ALDH1A3 ALDH1A3 VSX1 VSX1 SDK1 SDK1 MAN2A1 MAN2A1 ZHX2 ZHX2 RORB RORB COL8A1 COL8A1 RP1 RP1 CNTF CNTF TSKU TSKU MFSD2A MFSD2A PHACTR4 PHACTR4 BBS4 BBS4 CABP4 CABP4 NAGLU NAGLU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa)
THRBThyroid hormone receptor beta isoform X2. (476 aa)
PAX6Paired box 6. (498 aa)
TTNUncharacterized protein. (563 aa)
AHI1Abelson helper integration site 1. (1114 aa)
ATF4Activating transcription factor 4. (329 aa)
MFN2Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (860 aa)
TTC8Tetratricopeptide repeat domain 8. (587 aa)
SOX8SRY-box transcription factor 8. (460 aa)
RDH13Retinol dehydrogenase 13 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (334 aa)
LOC110258874Fork-head domain-containing protein. (493 aa)
C12orf57Chromosome 12 open reading frame 57. (126 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1507 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
TBC1D20TBC1 domain family member 20 isoform X1. (403 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
MEIS1Homeobox protein Meis1. (465 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
COL8A2Collagen type VIII alpha 2 chain. (707 aa)
MYPNMyopalladin isoform a. (1320 aa)
THTyrosine hydroxylase. (596 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
PROM1Prominin 1. (838 aa)
PITX2Homeobox protein. (326 aa)
THY1Thy-1 cell surface antigen. (165 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
ROM1Retinal outer segment membrane protein 1. (351 aa)
PROX1Prospero homeobox 1. (737 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
FRS2Fibroblast growth factor receptor substrate 2. (550 aa)
FOXF2Forkhead box F2. (443 aa)
TSPAN12Tetraspanin. (305 aa)
RPGRIP1RPGR interacting protein 1. (939 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
EPHB2EPH receptor B2. (987 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
FOXE3Forkhead box E3. (325 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
LCTLLactase like; Belongs to the glycosyl hydrolase 1 family. (567 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CRB2Crumbs cell polarity complex component 2. (1283 aa)
CALB1Calbindin 1. (261 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform 1. (1210 aa)
GNAT2G protein subunit alpha transducin 2. (354 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
KDM2BLysine demethylase 2B. (1312 aa)
FOXN4Fork-head domain-containing protein. (517 aa)
NF2Neurofibromin 2. (586 aa)
PDE6CPhosphodiesterase. (859 aa)
PITX3Homeobox protein. (298 aa)
CRB1Crumbs cell polarity complex component 1. (1464 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform 1. (205 aa)
DSCAMDS cell adhesion molecule. (2008 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
USH1CUSH1 protein network component harmonin. (858 aa)
SP3Sp3 transcription factor. (789 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
GLI3GLI family zinc finger 3. (1586 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
NF1Neurofibromin 1. (2847 aa)
FJX1Four-jointed box kinase 1. (437 aa)
TBX2T-box 2 protein. (714 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
HCN1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. (885 aa)
NRLNeural retina leucine zipper. (237 aa)
STRA6Stimulated by retinoic acid 6. (666 aa)
RING1Ring finger protein 1. (406 aa)
GDF11Growth/differentiation factor 11 preproprotein. (404 aa)
AQP5Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
CTNNB1Catenin beta 1. (808 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1244 aa)
RPGRIP1LProtein fantom isoform X1. (1270 aa)
BAK1Uncharacterized protein. (266 aa)
LHX1LIM homeobox 1. (436 aa)
YY1YY1 transcription factor. (438 aa)
RS1Retinoschisin 1. (228 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1128 aa)
IGFN1Uncharacterized protein. (1253 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
HIPK2Homeodomain interacting protein kinase 2. (1208 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
VSX1Visual system homeobox 1. (364 aa)
SDK1Sidekick cell adhesion molecule 1. (2141 aa)
MAN2A1Alpha-mannosidase. (1164 aa)
ZHX2Zinc fingers and homeoboxes 2. (827 aa)
RORBRAR related orphan receptor B. (548 aa)
COL8A1Collagen type VIII alpha 1 chain. (759 aa)
RP1RP1 axonemal microtubule associated. (2142 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity). (619 aa)
TSKUTsukushi, small leucine rich proteoglycan. (357 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (541 aa)
PHACTR4Phosphatase and actin regulator. (716 aa)
BBS4Uncharacterized protein. (826 aa)
CABP4Calcium binding protein 4. (311 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (744 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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