(19 nodes) Embryonic camera-type eye morphogenesis network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SP3	Sp3 transcription factor. (789 aa)
	KDM2B	Lysine demethylase 2B. (1312 aa)
	BMP7	Bone morphogenetic protein 7. (650 aa)
	HIPK1	Homeodomain-interacting protein kinase 1 isoform 1. (1210 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	STRA6	Stimulated by retinoic acid 6. (666 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
	PHACTR4	Phosphatase and actin regulator. (716 aa)
	FOXF2	Forkhead box F2. (443 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (550 aa)
	TBX2	T-box 2 protein. (714 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1208 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1128 aa)
	PAX6	Paired box 6. (498 aa)
	TH	Tyrosine hydroxylase. (596 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A3	STRA6	ENSSSCP00000074257	ENSSSCP00000002088	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	Stimulated by retinoic acid 6.	0.504
BMP7	IHH	ENSSSCP00000007993	ENSSSCP00000017167	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.456
CITED2	TFAP2A	ENSSSCP00000004474	ENSSSCP00000053009	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Transcription factor AP-2 alpha.	0.723
IHH	BMP7	ENSSSCP00000017167	ENSSSCP00000007993	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 7.	0.456
IHH	PAX6	ENSSSCP00000017167	ENSSSCP00000033621	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Paired box 6.	0.549
PAX6	IHH	ENSSSCP00000033621	ENSSSCP00000017167	Paired box 6.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.549
PAX6	TFAP2A	ENSSSCP00000033621	ENSSSCP00000053009	Paired box 6.	Transcription factor AP-2 alpha.	0.501
PAX6	TH	ENSSSCP00000033621	ENSSSCP00000047958	Paired box 6.	Tyrosine hydroxylase.	0.561
STRA6	ALDH1A3	ENSSSCP00000002088	ENSSSCP00000074257	Stimulated by retinoic acid 6.	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	0.504
TFAP2A	CITED2	ENSSSCP00000053009	ENSSSCP00000004474	Transcription factor AP-2 alpha.	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	0.723
TFAP2A	PAX6	ENSSSCP00000053009	ENSSSCP00000033621	Transcription factor AP-2 alpha.	Paired box 6.	0.501
TH	PAX6	ENSSSCP00000047958	ENSSSCP00000033621	Tyrosine hydroxylase.	Paired box 6.	0.561