(57 nodes) Neuron fate commitment network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
	HOXC10	Homeobox C10. (342 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
	PTF1A	Pancreas associated transcription factor 1a. (328 aa)
	LBX1	Ladybird homeobox 1. (281 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	EHMT2	Uncharacterized protein. (1233 aa)
	DMRTA2	Doublesex-and mab-3-related transcription factor A2. (535 aa)
	BCL11B	Uncharacterized protein. (888 aa)
	ZNF521	Zinc finger protein 521. (1310 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (272 aa)
	SMAD4	Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SIX1	Six homeobox 1. (284 aa)
	ID2	DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
	GSX2	GS homeobox 2. (304 aa)
	ATOH1	Atonal bHLH transcription factor 1. (353 aa)
	GSX1	GS homeobox 1. (267 aa)
	FOXN4	Fork-head domain-containing protein. (517 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (432 aa)
	FEZF2	FEZ family zinc finger 2. (503 aa)
	OLIG1	Oligodendrocyte transcription factor 1. (269 aa)
	DBX1	Developing brain homeobox 1. (343 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	HOXD10	Homeobox protein Hox-D10. (410 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
	MNX1	Motor neuron and pancreas homeobox 1. (401 aa)
	GLI3	GLI family zinc finger 3. (1586 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	TLX3	T cell leukemia homeobox 3. (338 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	EPOP	Elongin BC and polycomb repressive complex 2 associated protein. (379 aa)
	NKX6-2	Homeobox protein Nkx-6.2. (277 aa)
	MYT1L	Myelin transcription factor 1 like. (1193 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	NKX2-1	NK2 homeobox 1. (399 aa)
	ISL2	ISL LIM homeobox 2. (359 aa)
	NKX2-2	Homeobox protein Nkx-2.2. (273 aa)
	POU4F1	POU domain protein. (421 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	FEV	FEV transcription factor, ETS family member. (237 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
	GBX1	Gastrulation brain homeobox 1. (365 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (473 aa)
	FOXA1	Forkhead box A1. (468 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
	FOXG1	Forkhead box G1. (486 aa)
	PRRX1	Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa)
	DLX1	Homeobox protein DLX-1 isoform 1. (255 aa)
	LOC110258874	Fork-head domain-containing protein. (493 aa)
	LHX3	LIM/homeobox protein Lhx3; Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). (538 aa)
	PAX6	Paired box 6. (498 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (323 aa)
	CTNNB1	Catenin beta 1. (808 aa)
	TGFBR1	TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1371 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	DBX1	ENSSSCP00000009805	ENSSSCP00000014184	Atonal bHLH transcription factor 1.	Developing brain homeobox 1.	0.708
ATOH1	DLL1	ENSSSCP00000009805	ENSSSCP00000025758	Atonal bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.624
ATOH1	DLL4	ENSSSCP00000009805	ENSSSCP00000055160	Atonal bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.414
ATOH1	EYA1	ENSSSCP00000009805	ENSSSCP00000038801	Atonal bHLH transcription factor 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.512
ATOH1	FOXG1	ENSSSCP00000009805	ENSSSCP00000037951	Atonal bHLH transcription factor 1.	Forkhead box G1.	0.603
ATOH1	JAG2	ENSSSCP00000009805	ENSSSCP00000028498	Atonal bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.455
ATOH1	NOTCH1	ENSSSCP00000009805	ENSSSCP00000050060	Atonal bHLH transcription factor 1.	Neurogenic locus notch homolog protein 1 preproprotein.	0.601
ATOH1	OLIG3	ENSSSCP00000009805	ENSSSCP00000004490	Atonal bHLH transcription factor 1.	Oligodendrocyte transcription factor 3.	0.534
ATOH1	PAX6	ENSSSCP00000009805	ENSSSCP00000033621	Atonal bHLH transcription factor 1.	Paired box 6.	0.436
ATOH1	POU4F1	ENSSSCP00000009805	ENSSSCP00000053309	Atonal bHLH transcription factor 1.	POU domain protein.	0.572
ATOH1	PTF1A	ENSSSCP00000009805	ENSSSCP00000025304	Atonal bHLH transcription factor 1.	Pancreas associated transcription factor 1a.	0.626
ATOH1	SHH	ENSSSCP00000009805	ENSSSCP00000017394	Atonal bHLH transcription factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.595
ATOH1	SIX1	ENSSSCP00000009805	ENSSSCP00000005467	Atonal bHLH transcription factor 1.	Six homeobox 1.	0.495
ATOH1	SOX9	ENSSSCP00000009805	ENSSSCP00000018278	Atonal bHLH transcription factor 1.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.428
ATOH1	TLX3	ENSSSCP00000009805	ENSSSCP00000018011	Atonal bHLH transcription factor 1.	T cell leukemia homeobox 3.	0.507
BCL11B	DLX1	ENSSSCP00000002714	ENSSSCP00000036907	Uncharacterized protein.	Homeobox protein DLX-1 isoform 1.	0.514
BCL11B	DLX2	ENSSSCP00000002714	ENSSSCP00000016906	Uncharacterized protein.	Distal-less homeobox 2.	0.471
BCL11B	NOTCH1	ENSSSCP00000002714	ENSSSCP00000050060	Uncharacterized protein.	Neurogenic locus notch homolog protein 1 preproprotein.	0.406
BCL11B	TBR1	ENSSSCP00000002714	ENSSSCP00000016840	Uncharacterized protein.	T-box brain transcription factor 1.	0.694
BMP4	CTNNB1	ENSSSCP00000005423	ENSSSCP00000031836	Bone morphogenetic protein 4.	Catenin beta 1.	0.604