STRINGSTRING
DLX2 DLX2 FLVCR1 FLVCR1 BMI1 BMI1 SIX2 SIX2 IFT140 IFT140 BMP7 BMP7 OSR2 OSR2 SIX1 SIX1 BMP4 BMP4 FUZ FUZ MEGF8 MEGF8 GSC GSC MDFI MDFI TULP3 TULP3 MED12 MED12 MMP16 MMP16 MTHFD1L MTHFD1L NODAL NODAL SLC39A1 SLC39A1 HOXC9 HOXC9 PDGFRA PDGFRA ALX1 ALX1 WDR60 WDR60 SETD2 SETD2 TFAP2A TFAP2A NOG NOG CHST11 CHST11 NIPBL NIPBL HOXB9 HOXB9 HYAL1 HYAL1 WNT9B WNT9B ALX3 ALX3 DLG2 DLG2 MYF5 MYF5 FGF8 FGF8 DSCAML1 DSCAML1 RUNX2 RUNX2 GRHL2 GRHL2 SMAD3 SMAD3 HOXB2 HOXB2 HOXB1 HOXB1 EIF4A3 EIF4A3 GLI3 GLI3 HOXA2 HOXA2 HOXA3 HOXA3 HOXA5 HOXA5 HOXA11 HOXA11 HOXD3 HOXD3 HOXD4 HOXD4 OSR1 OSR1 SIX4 SIX4 RDH10 RDH10 NDST1 NDST1 IRX5 IRX5 CTNNB1 CTNNB1 LHX1 LHX1 DLG1 DLG1 TGFBR1 TGFBR1 FGFR2 FGFR2 GNAS GNAS ZEB1 ZEB1 SATB2 SATB2 HOXC11 HOXC11 WDR19 WDR19 HOXA7 HOXA7 MMP14 MMP14 HOXA9 HOXA9 SHOX2 SHOX2 HOXD9 HOXD9 HOXD10 HOXD10 COL2A1 COL2A1 PCGF2 PCGF2 ALX4 ALX4 HOXB5 HOXB5 HOXB6 HOXB6 HOXB7 HOXB7 HOXB8 HOXB8 HOXB4 HOXB4 HOXB3 HOXB3 PRRX1 PRRX1 EYA1 EYA1 HOXC4 HOXC4 PAX5 PAX5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLX2Distal-less homeobox 2. (328 aa)
FLVCR1Feline leukemia virus subgroup C receptor-related protein 1. (559 aa)
BMI1RING-type domain-containing protein. (336 aa)
SIX2SIX homeobox 2. (296 aa)
IFT140Intraflagellar transport 140. (1477 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
SIX1Six homeobox 1. (284 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
GSCGoosecoid homeobox. (256 aa)
MDFIMyoD family inhibitor. (246 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (472 aa)
MED12Mediator complex subunit 12. (2187 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (975 aa)
NODALNodal growth differentiation factor. (316 aa)
SLC39A1Solute carrier family 39 member 1. (481 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
ALX1ALX homeobox 1. (326 aa)
WDR60WD repeat domain 60. (1029 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2557 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
NIPBLNipped-B protein. (2804 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
HYAL1Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity); Belongs to the glycosyl hydrolase 56 family. (650 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
ALX3ALX homeobox 3. (362 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (253 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
DSCAML1DS cell adhesion molecule like 1. (2111 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
GRHL2Grainyhead like transcription factor 2. (626 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
HOXB2Homeobox protein Hox-B2. (353 aa)
HOXB1Homeobox protein Hox-B1. (301 aa)
EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (488 aa)
GLI3GLI family zinc finger 3. (1586 aa)
HOXA2Homeobox protein Hox-A2. (380 aa)
HOXA3Homeobox protein Hox-A3 isoform a. (443 aa)
HOXA5Homeobox domain-containing protein. (381 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
HOXD3Homeobox protein Hox-D3. (432 aa)
HOXD4Homeobox protein Hox-D4. (257 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
SIX4Homeobox domain-containing protein. (785 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
NDST1Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2. (882 aa)
IRX5Iroquois homeobox 5. (483 aa)
CTNNB1Catenin beta 1. (808 aa)
LHX1LIM homeobox 1. (436 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
GNASGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (1045 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1128 aa)
SATB2DNA-binding protein SATB. (733 aa)
HOXC11Homeobox C11. (304 aa)
WDR19WD repeat domain 19. (1342 aa)
HOXA7Homeobox A7. (234 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
SHOX2Short stature homeobox 2. (321 aa)
HOXD9Homeobox D9. (351 aa)
HOXD10Homeobox protein Hox-D10. (410 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (344 aa)
ALX4ALX homeobox 4. (406 aa)
HOXB5Homeobox protein Hox-B5. (269 aa)
HOXB6Homeobox protein Hox-B6 isoform X1. (224 aa)
HOXB7Homeobox protein Hox-B7. (217 aa)
HOXB8Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (242 aa)
HOXB4Homeobox B4. (278 aa)
HOXB3Homeobox B3. (430 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
HOXC4Homeobox protein Hox-C4. (264 aa)
PAX5Paired box 5. (390 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.