STRINGSTRING
LOC110258323 LOC110258323 AGER AGER PSEN1 PSEN1 BMP2 BMP2 TREM2 TREM2 TAL1 TAL1 IFNG IFNG GPR37L1 GPR37L1 GCM1 GCM1 SOX8 SOX8 LAMC3 LAMC3 VAX1 VAX1 APP APP PLP1 PLP1 CUL4B CUL4B TTC21B TTC21B SHH SHH SMO SMO SOX9 SOX9 GFAP GFAP STAT3 STAT3 NF1 NF1 KRAS KRAS EIF2B5 EIF2B5 DLL1 DLL1 NR2E1 NR2E1 C5AR1 C5AR1 S100A9 S100A9 S100A8 S100A8 MT3 MT3 PAX6 PAX6 MAPK1 MAPK1 GAP43 GAP43 CNTF CNTF PLPP3 PLPP3 PTPN11 PTPN11 C1QA C1QA MAPK3 MAPK3 TSPAN2 TSPAN2 MAP2K1 MAP2K1 NKX2-2 NKX2-2 HES5 HES5 ABL1 ABL1 LAMB2 LAMB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC110258323Protein S100; Belongs to the S-100 family. (133 aa)
AGERAdvanced glycosylation end-product specific receptor. (487 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
TREM2Ig-like domain-containing protein. (248 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
GPR37L1G protein-coupled receptor 37 like 1. (459 aa)
GCM1Glial cells missing transcription factor 1. (431 aa)
SOX8SRY-box transcription factor 8. (460 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
VAX1Ventral anterior homeobox 1. (333 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa)
PLP1Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (By similarity); Belongs to the myelin proteolipid protein family. (329 aa)
CUL4BCullin 4B; Belongs to the cullin family. (1056 aa)
TTC21BTetratricopeptide repeat protein 21B. (1315 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (468 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
NF1Neurofibromin 1. (2847 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (702 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (222 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa)
PAX6Paired box 6. (498 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
GAP43Uncharacterized protein. (244 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity). (619 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
C1QAComplement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (266 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
TSPAN2Tetraspanin. (335 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
LAMB2Laminin subunit beta-2. (1881 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (18%) [HD]