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| | APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | HAND2 | Heart-and neural crest derivatives-expressed protein 2. (217 aa) |
| | ORAI1 | Uncharacterized protein. (408 aa) |
| | GLI1 | Zinc finger protein GLI1 isoform X1. (1106 aa) |
| | NKX3-1 | Homeobox protein Nkx-3.1 isoform 1. (247 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | CSF1 | Colony stimulating factor 1. (656 aa) |
| | E2F8 | E2F transcription factor 8. (859 aa) |
| | ARF6 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...] (175 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | ZBTB7B | Zinc finger and BTB domain-containing protein 7B isoform X1. (543 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | ZNF330 | Zinc finger protein 330. (326 aa) |
| | PKD1 | Polycystin 1, transient receptor potential channel interacting. (4383 aa) |
| | DKK3 | Dickkopf WNT signaling pathway inhibitor 3. (433 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (603 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | E2F7 | E2F transcription factor 7. (908 aa) |
| | TGM2 | Transglutaminase 2. (696 aa) |
| | NTN1 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (651 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (229 aa) |
| | ATP2C2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (947 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (365 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (505 aa) |
| | ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa) |
| | HNF1B | Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the PFC element in the UPA gene. (577 aa) |
| | TWSG1 | Twisted gastrulation BMP signaling modulator 1. (291 aa) |
| | CLCN2 | Chloride channel protein. (1026 aa) |
| | CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (513 aa) |
| | CADM1 | Cell adhesion molecule 1. (473 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (434 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | EAF2 | ELL associated factor 2. (273 aa) |
| | ZBTB1 | Zinc finger and BTB domain-containing protein 1 isoform X1. (713 aa) |
| | ARID5B | AT-rich interaction domain 5B. (1194 aa) |
| | MAN2A1 | Alpha-mannosidase. (1164 aa) |
| | HLX | H2.0 like homeobox. (556 aa) |
| | IGSF3 | Immunoglobulin superfamily member 3. (1210 aa) |
| | ADA | Adenosine deaminase. (409 aa) |
| | PLXND1 | Plexin D1. (1926 aa) |
| | NOTCH4 | Uncharacterized protein. (1993 aa) |
| | LRRC1 | Leucine rich repeat containing 1. (524 aa) |
| | SRF | Serum response factor. (512 aa) |
| | STRA6 | Stimulated by retinoic acid 6. (666 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | SRP54 | Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa) |
| | RIPK3 | Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (493 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa) |
| | BCL11B | Uncharacterized protein. (888 aa) |
| | DNAAF1 | Dynein assembly factor 1, axonemal. (650 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (371 aa) |
| | SALL1 | Spalt like transcription factor 1. (1326 aa) |
| | LSR | Lipolysis stimulated lipoprotein receptor. (598 aa) |
| | ARHGAP35 | Rho GTPase-activating protein 35. (1500 aa) |
| | BAX | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa) |
| | EPHA2 | Ephrin type-A receptor 2 isoform 1. (975 aa) |
| | CSMD2 | Uncharacterized protein. (1106 aa) |
| | GATA6 | Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa) |
| | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa) |
| | LOC100511607 | Uncharacterized protein. (340 aa) |
| | LOC100512146 | Uncharacterized protein. (358 aa) |
| | SEC63 | SEC63 homolog, protein translocation regulator. (760 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa) |
| | ONECUT2 | One cut domain family member. (694 aa) |
| | ONECUT1 | One cut domain family member. (465 aa) |
| | DUOX2 | Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1539 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (375 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | SIX1 | Six homeobox 1. (284 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | FOXE1 | Forkhead box E1. (373 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | CRH | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. (191 aa) |
| | PLAG1 | PLAG1 zinc finger. (499 aa) |
| | IQGAP3 | IQ motif containing GTPase activating protein 3. (1696 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) |
| | WDR77 | WD repeat domain 77. (342 aa) |
| | GPAT4 | PlsC domain-containing protein. (457 aa) |
| | PAX1 | Paired box 1. (454 aa) |
| | ASXL1 | ASXL transcriptional regulator 1. (1542 aa) |
| | GHRH | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. (106 aa) |
| | SULF2 | Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (906 aa) |
| | BMP7 | Bone morphogenetic protein 7. (650 aa) |
| | GFER | Sulfhydryl oxidase. (365 aa) |
| | BCL2L11 | Uncharacterized protein. (433 aa) |
| | EDAR | Ectodysplasin A receptor. (461 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa) |
| | ID2 | DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa) |
| | PSAPL1 | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (518 aa) |
| | MSX1 | Homeobox domain-containing protein. (303 aa) |
| | AREG | Amphiregulin long form. (247 aa) |
| | EDNRA | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa) |
| | PKD2 | Polycystin 2, transient receptor potential cation channel. (970 aa) |
| | CSN2 | Beta-casein; Important role in determination of the surface properties of the casein micelles. (231 aa) |
| | CSN3 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. (187 aa) |
| | GSX1 | GS homeobox 1. (267 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa) |
| | TBX3 | T-box transcription factor TBX3 isoform 2. (745 aa) |
| | HNF1A | Hepatocyte nuclear factor 1-alpha isoform 2. (631 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | NKX2-3 | NK2 homeobox 3. (367 aa) |
| | NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (638 aa) |
| | ELF3 | E74 like ETS transcription factor 3. (456 aa) |
| | KDM5B | Lysine-specific demethylase 5B isoform 2. (1547 aa) |
| | MST1 | Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa) |
| | CCDC39 | Coiled-coil domain-containing protein 39. (942 aa) |
| | EPHB3 | Ephrin type-B receptor 3. (999 aa) |
| | NR0B1 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. (490 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa) |
| | ZIC3 | Zic family member 3. (467 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | RELA | Transcription factor p65 isoform 1. (573 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | PRKCSH | Glucosidase 2 subunit beta isoform X1. (537 aa) |
| | OTP | Orthopedia homeobox. (325 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa) |
| | BSX | Brain specific homeobox. (232 aa) |
| | HGF | Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa) |
| | F1SF13_PIG | Cobl domain-containing protein. (406 aa) |
| | TFCP2L1 | Transcription factor CP2 like 1. (478 aa) |
| | CSMD1 | CUB and Sushi multiple domains 1. (3258 aa) |
| | ZNF703 | Zinc finger protein 703. (591 aa) |
| | SP3 | Sp3 transcription factor. (789 aa) |
| | HOXD13 | Homeobox protein Hox-D13. (341 aa) |
| | HOXD9 | Homeobox D9. (351 aa) |
| | HOXD3 | Homeobox protein Hox-D3. (432 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1201 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa) |
| | GHRHR | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. (451 aa) |
| | HOXA5 | Homeobox domain-containing protein. (381 aa) |
| | HOXA3 | Homeobox protein Hox-A3 isoform a. (443 aa) |
| | GLI3 | GLI family zinc finger 3. (1586 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1. (349 aa) |
| | SLC6A3 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (614 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa) |
| | CRHR1 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (415 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa) |
| | HOXB3 | Homeobox B3. (430 aa) |
| | HOXB13 | Homeobox B13. (285 aa) |
| | CCL11 | C-C motif chemokine. (97 aa) |
| | NF1 | Neurofibromin 1. (2847 aa) |
| | FOXN1 | Forkhead box N1. (671 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa) |
| | ASH1L | ASH1 like histone lysine methyltransferase. (2963 aa) |
| | WT1 | Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | FEM1B | Protein fem-1 homolog B. (627 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa) |
| | I3LA07_PIG | Uncharacterized protein. (398 aa) |
| | CCDC40 | Coiled-coil domain containing 40. (986 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa) |
| | TBX2 | T-box 2 protein. (714 aa) |
| | GDF7 | Growth differentiation factor 7. (449 aa) |
| | SEMA3C | Semaphorin-3C isoform 2; Belongs to the semaphorin family. (751 aa) |
| | HOXA9 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | FASN | Uncharacterized protein. (1430 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (217 aa) |
| | PROP1 | Homeobox protein prophet of Pit-1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. (226 aa) |
| | RB1CC1 | RB1 inducible coiled-coil 1. (1608 aa) |
| | PCSK9 | Proprotein convertase subtilisin/kexin type 9. (678 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | IGFBP5 | Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (271 aa) |
| | HESX1 | HESX homeobox 1. (185 aa) |
| | AIRE | Autoimmune regulator. (559 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) |
| | HOXA13 | Homeobox A13. (388 aa) |
| | UPF2 | UPF2 regulator of nonsense mediated mRNA decay. (1270 aa) |
| | PTCH1 | Protein patched homolog 1 isoform L. (1452 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (629 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (841 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (389 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | TGFB3 | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa) |
| | TGFBR1 | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa) |
| | DDR1 | Tyrosine-protein kinase receptor. (1005 aa) |
| | NRG3 | Neuregulin 3. (718 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | RPGRIP1L | Protein fantom isoform X1. (1270 aa) |
| | RARG | Retinoic acid receptor gamma. (554 aa) |
| | PRL | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. (229 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (334 aa) |
| | PAX6 | Paired box 6. (498 aa) |
| | VDR | Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (429 aa) |
| | RXFP1 | Relaxin family peptide receptor 1. (785 aa) |
| | PITX1 | Homeobox protein. (314 aa) |
| | LHX3 | LIM/homeobox protein Lhx3; Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). (538 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa) |
| | SIX4 | Homeobox domain-containing protein. (785 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (804 aa) |
| | SOX10 | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa) |
| | ESRP2 | Epithelial splicing regulatory protein 2. (717 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | FGL1 | Fibrinogen like 1. (315 aa) |
| | BMP2 | Bone morphogenetic protein 2 preproprotein. (395 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (773 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (737 aa) |
| | PLXNA1 | Plexin A1. (1909 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | ATP7B | Uncharacterized protein. (275 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa) |
| | GCM2 | Glial cells missing transcription factor 2. (503 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | NKX2-5 | NK2 homeobox 5. (323 aa) |
| | IRF6 | Interferon regulatory factor 6. (467 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (164 aa) |
| | FOXF1 | Forkhead box protein F1. (423 aa) |
| | FOXA1 | Forkhead box A1. (468 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa) |
| | SELENOH | Uncharacterized protein. (122 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa) |
| | CACNB4 | SH3 domain-containing protein. (519 aa) |
| | FRZB | Secreted frizzled-related protein 3. (325 aa) |
| | MSN | Moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. (612 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1146 aa) |
| | RHBDD3 | Rhomboid domain-containing protein 3. (428 aa) |
| | BAAT | Bile acid-CoA:amino acid N-acyltransferase. (407 aa) |
| | CDKN1B | p27Kip1. (198 aa) |
| | JARID2 | Jumonji and AT-rich interaction domain containing 2. (1245 aa) |
| | FOXB1 | Forkhead box protein B1. (325 aa) |
| | SLC46A2 | Solute carrier family 46 member 2. (494 aa) |
| | DDX55 | RNA helicase. (600 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa) |
| | NME1 | Nucleoside diphosphate kinase. (152 aa) |
| | HES1 | Uncharacterized protein. (280 aa) |
| | NR5A1 | Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidy [...] (461 aa) |
| | NODAL | Nodal growth differentiation factor. (316 aa) |
| | TNC | Tenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha- V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Belongs to the tenascin family. (2420 aa) |
| | NFKB1 | Uncharacterized protein. (898 aa) |
| | USF2 | Upstream transcription factor 2, c-fos interacting. (391 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | SERPINE2 | SERPIN domain-containing protein; Belongs to the serpin family. (378 aa) |
| | A0A287AZ68_PIG | PDZ domain-containing protein. (909 aa) |
| | SERPINF1 | Serpin family F member 1; Belongs to the serpin family. (433 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha isoform 1. (824 aa) |
| | ARMC5 | Armadillo repeat containing 5. (963 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | IRS2 | Insulin receptor substrate 2. (1092 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TCF21 | Transcription factor 21. (179 aa) |
| | PDX1 | Homeobox domain-containing protein. (284 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (550 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1201 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | ABL1 | Tyrosine-protein kinase. (1146 aa) |
| | ZDHHC21 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa) |
| | NPHP3 | TPR_REGION domain-containing protein. (1368 aa) |
| | NKX2-1 | NK2 homeobox 1. (399 aa) |
| | HOXB9 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
