STRINGSTRING
BIN3 BIN3 P2RX2 P2RX2 KEL KEL MYORG MYORG C9orf24 C9orf24 CACNA1S CACNA1S PLEC PLEC SELENON SELENON WNT10B WNT10B RIPOR2 RIPOR2 ACTC1 ACTC1 SIX1 SIX1 PPP3CA PPP3CA ACTA2 ACTA2 KLHL40 KLHL40 MYOD1 MYOD1 DNER DNER SMO SMO CAV2 CAV2 STAC3 STAC3 SPG11 SPG11 ACTN1 ACTN1 PPP3CB PPP3CB HOMER1 HOMER1 KLHL41 KLHL41 R3HDM2 R3HDM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BIN3Bridging integrator 3. (324 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (459 aa)
KELKell metallo-endopeptidase (Kell blood group). (763 aa)
MYORGMyogenesis regulating glycosidase (putative); Belongs to the glycosyl hydrolase 31 family. (713 aa)
C9orf24Chromosome 9 open reading frame 24. (262 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PLECPlectin. (5422 aa)
SELENONSelenoprotein N. (556 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
RIPOR2PL48 domain-containing protein. (1063 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
SIX1Six homeobox 1. (284 aa)
PPP3CASerine/threonine-protein phosphatase. (523 aa)
ACTA2Actin alpha 2, smooth muscle. (386 aa)
KLHL40Kelch like family member 40. (623 aa)
MYOD1Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (319 aa)
DNERDelta/notch like EGF repeat containing. (738 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2467 aa)
ACTN1Uncharacterized protein. (888 aa)
PPP3CBSerine/threonine-protein phosphatase. (527 aa)
HOMER1Homer scaffold protein 1. (365 aa)
KLHL41Kelch like family member 41. (601 aa)
R3HDM2Uncharacterized protein. (1079 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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