22 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A5G2R9S5_PIG	SCHIP-1 domain-containing protein. (485 aa)
	SRF	Serum response factor. (512 aa)
	STRA6	Stimulated by retinoic acid 6. (666 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SIX1	Six homeobox 1. (284 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (213 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (970 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	NF1	Neurofibromin 1. (2847 aa)
	TIPARP	TCDD inducible poly(ADP-ribose) polymerase. (657 aa)
	PTCH1	Protein patched homolog 1 isoform L. (1452 aa)
	ENG	Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
	COL3A1	Collagen alpha-1(III) chain preproprotein. (1471 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	TFAP2B	Transcription factor AP-2 beta. (469 aa)
	MYLK	Myosin light chain kinase, smooth muscle; Phosphorylates a specific serine in the N-terminus of a myosin light chain. Also regulates actin-myosin interaction through a non-kinase activity (By similarity). (1981 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (1012 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5G2R9S5_PIG	TIPARP	ENSSSCP00000067350	ENSSSCP00000026315	SCHIP-1 domain-containing protein.	TCDD inducible poly(ADP-ribose) polymerase.	0.544
A0A5G2R9S5_PIG	ZFAND5	ENSSSCP00000067350	ENSSSCP00000005655	SCHIP-1 domain-containing protein.	Zinc finger AN1-type containing 5.	0.746
BMP4	ENG	ENSSSCP00000005423	ENSSSCP00000030121	Bone morphogenetic protein 4.	Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...]	0.435
BMP4	IHH	ENSSSCP00000005423	ENSSSCP00000017167	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.721
BMP4	PTCH1	ENSSSCP00000005423	ENSSSCP00000028104	Bone morphogenetic protein 4.	Protein patched homolog 1 isoform L.	0.575
BMP4	SHH	ENSSSCP00000005423	ENSSSCP00000017394	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.850
BMP4	SMO	ENSSSCP00000005423	ENSSSCP00000017553	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.405
BMP4	SOX9	ENSSSCP00000005423	ENSSSCP00000018278	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.698
DLG1	DLG2	ENSSSCP00000030935	ENSSSCP00000062580	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 2.	0.901
DLG2	DLG1	ENSSSCP00000062580	ENSSSCP00000030935	Discs large MAGUK scaffold protein 2.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.901
ENG	BMP4	ENSSSCP00000030121	ENSSSCP00000005423	Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...]	Bone morphogenetic protein 4.	0.435
ENG	SOX9	ENSSSCP00000030121	ENSSSCP00000018278	Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...]	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.485
IHH	BMP4	ENSSSCP00000017167	ENSSSCP00000005423	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.721
IHH	PTCH1	ENSSSCP00000017167	ENSSSCP00000028104	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Protein patched homolog 1 isoform L.	0.997
IHH	SHH	ENSSSCP00000017167	ENSSSCP00000017394	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.924
IHH	SMO	ENSSSCP00000017167	ENSSSCP00000017553	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.854
IHH	SOX9	ENSSSCP00000017167	ENSSSCP00000018278	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.716
PKD2	SMO	ENSSSCP00000009827	ENSSSCP00000017553	Polycystin 2, transient receptor potential cation channel.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.553
PTCH1	BMP4	ENSSSCP00000028104	ENSSSCP00000005423	Protein patched homolog 1 isoform L.	Bone morphogenetic protein 4.	0.575
PTCH1	IHH	ENSSSCP00000028104	ENSSSCP00000017167	Protein patched homolog 1 isoform L.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.997