(49 nodes) Presynaptic active zone network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERC2	ELKS/RAB6-interacting/CAST family member 2. (969 aa)
	ARHGAP44	Rho GTPase activating protein 44. (812 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1348 aa)
	UNC13B	Uncharacterized protein. (4266 aa)
	BSN	Bassoon presynaptic cytomatrix protein. (3942 aa)
	TPRG1L	HSac2 domain-containing protein. (277 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1684 aa)
	OTOF	Otoferlin. (1997 aa)
	NTNG1	Netrin G1. (588 aa)
	UNC13C	Unc-13 homolog C. (2214 aa)
	PPFIBP1	PPFIA binding protein 1. (1036 aa)
	CPLX3	Complexin 3. (158 aa)
	LRFN3	Leucine rich repeat and fibronectin type III domain containing 3. (627 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
	STX11	Syntaxin-11 isoform X1; Belongs to the syntaxin family. (287 aa)
	SV2A	Synaptic vesicle glycoprotein 2A isoform 1. (742 aa)
	SLC32A1	Vesicular inhibitory amino acid transporter. (526 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (295 aa)
	CTBP2	C-terminal binding protein 2. (982 aa)
	APP	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa)
	SYP	Synaptophysin. (319 aa)
	RAB3A	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa)
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
	PPFIA4	PTPRF interacting protein alpha 4. (1210 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (845 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (5107 aa)
	PNISR	PNN interacting serine and arginine rich protein. (814 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	SYN1	Synapsin-1 isoform Ia. (712 aa)
	STX2	Syntaxin 2; Belongs to the syntaxin family. (347 aa)
	PPFIA2	PTPRF interacting protein alpha 2. (1286 aa)
	CTNNB1	Catenin beta 1. (808 aa)
	PPFIA3	PTPRF interacting protein alpha 3. (1235 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	STXBP1	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (609 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (428 aa)
	NPTN	Neuroplastin. (412 aa)
	NTNG2	Netrin G2. (529 aa)
	GAD1	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (728 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (347 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (338 aa)
	CPLX2	Complexin 2. (163 aa)
	UNC13A	Uncharacterized protein. (1581 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1. (1092 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
	ZZEF1	Zinc finger ZZ-type and EF-hand domain containing 1. (2877 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (312 aa)
	PPFIA1	PTPRF interacting protein alpha 1. (1231 aa)
	PPFIBP2	PPFIA binding protein 2. (979 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	APP	ENSSSCP00000019515	ENSSSCP00000012805	Amyloid beta precursor protein binding family A member 1.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.896
APBA1	PPFIA1	ENSSSCP00000019515	ENSSSCP00000050869	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 1.	0.552
APBA1	PPFIA2	ENSSSCP00000019515	ENSSSCP00000031552	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 2.	0.552
APBA1	PPFIA3	ENSSSCP00000019515	ENSSSCP00000032639	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 3.	0.600
APBA1	PPFIA4	ENSSSCP00000019515	ENSSSCP00000016406	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 4.	0.552
APBA1	RAB3A	ENSSSCP00000019515	ENSSSCP00000014777	Amyloid beta precursor protein binding family A member 1.	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	0.519
APBA1	RIMS1	ENSSSCP00000019515	ENSSSCP00000062116	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 1.	0.559
APBA1	STX1A	ENSSSCP00000019515	ENSSSCP00000008300	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1A; Belongs to the syntaxin family.	0.917
APBA1	STX2	ENSSSCP00000019515	ENSSSCP00000028996	Amyloid beta precursor protein binding family A member 1.	Syntaxin 2; Belongs to the syntaxin family.	0.464
APBA1	STX3	ENSSSCP00000019515	ENSSSCP00000042626	Amyloid beta precursor protein binding family A member 1.	Syntaxin 3; Belongs to the syntaxin family.	0.464
APBA1	STX4	ENSSSCP00000019515	ENSSSCP00000044112	Amyloid beta precursor protein binding family A member 1.	Syntaxin 4; Belongs to the syntaxin family.	0.464
APBA1	STXBP1	ENSSSCP00000019515	ENSSSCP00000037046	Amyloid beta precursor protein binding family A member 1.	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.	0.991
APBA1	SYN1	ENSSSCP00000019515	ENSSSCP00000028857	Amyloid beta precursor protein binding family A member 1.	Synapsin-1 isoform Ia.	0.507
APBA1	UNC13B	ENSSSCP00000019515	ENSSSCP00000067794	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein.	0.506
APP	APBA1	ENSSSCP00000012805	ENSSSCP00000019515	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor protein binding family A member 1.	0.896
APP	CDH2	ENSSSCP00000012805	ENSSSCP00000004030	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.500
APP	CTNNB1	ENSSSCP00000012805	ENSSSCP00000031836	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Catenin beta 1.	0.529
APP	SYN1	ENSSSCP00000012805	ENSSSCP00000028857	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Synapsin-1 isoform Ia.	0.579
APP	SYP	ENSSSCP00000012805	ENSSSCP00000013081	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Synaptophysin.	0.696
BSN	ERC2	ENSSSCP00000067587	ENSSSCP00000053547	Bassoon presynaptic cytomatrix protein.	ELKS/RAB6-interacting/CAST family member 2.	0.483