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SOX10 SOX10 LMBR1L LMBR1L ERCC2 ERCC2 TGFB2 TGFB2 RDH10 RDH10 SOX8 SOX8 SEMA6C SEMA6C CTNNB1 CTNNB1 PHF5A PHF5A ESR1 ESR1 ITGB1 ITGB1 CDK6 CDK6 FOXO4 FOXO4 SEMA4D SEMA4D SFRP1 SFRP1 UFL1 UFL1 SEMA3A SEMA3A HESX1 HESX1 HOXA7 HOXA7 GPM6A GPM6A ZFP36 ZFP36 SEMA7A SEMA7A SEMA3C SEMA3C TBX2 TBX2 MED1 MED1 HOXB4 HOXB4 PSMD11 PSMD11 OTUD5 OTUD5 WNT10A WNT10A FAM172A FAM172A CORO1C CORO1C DMRTA2 DMRTA2 MYOCD MYOCD PHACTR4 PHACTR4 TCOF1 TCOF1 KIT KIT TP63 TP63 XRCC5 XRCC5 HMGA2 HMGA2 EDNRB EDNRB SETD6 SETD6 SEMA5A SEMA5A MLLT3 MLLT3 SEMA4F SEMA4F PHOX2B PHOX2B EPOP EPOP MAPK1 MAPK1 ALDH1A2 ALDH1A2 REST REST MAPK3 MAPK3 RADIL RADIL GBX2 GBX2 SHH SHH SMO SMO ISL1 ISL1 ANXA6 ANXA6 SOX9 SOX9 SEMA3D SEMA3D BBS12 BBS12 PEF1 PEF1 RUNX2 RUNX2 NRP1 NRP1 METTL5 METTL5 POU5F1 POU5F1 SRF SRF GSC GSC SLC9A1 SLC9A1 GATA6 GATA6 CDH2 CDH2 CITED2 CITED2 SMAD4 SMAD4 SEMA6D SEMA6D ELL3 ELL3 SIX1 SIX1 LOC100359361 LOC100359361 EXT1 EXT1 SOX17 SOX17 JAG1 JAG1 MSX1 MSX1 SFRP2 SFRP2 EDNRA EDNRA CDX2 CDX2 HTR2B HTR2B ERBB4 ERBB4 HOXD4 HOXD4 SEMA3E SEMA3E MEF2C MEF2C ZIC3 ZIC3 KBTBD8 KBTBD8 SEMA3G SEMA3G SEMA3F SEMA3F ZNF281 ZNF281 NOLC1 NOLC1 CYP26C1 CYP26C1 RET RET TBX3 TBX3 SH2B3 SH2B3 SOX21 SOX21 NELFB NELFB HAND2 HAND2 EFNB1 EFNB1 NANOG NANOG ACVR1 ACVR1 KLHL12 KLHL12 FGF2 FGF2 SEMA4G SEMA4G NRTN NRTN NOG NOG SP7 SP7 SETD2 SETD2 SEMA6A SEMA6A HIF1A HIF1A SEMA5B SEMA5B TP53 TP53 MTF2 MTF2 NRP2 NRP2 NOTCH1 NOTCH1 SEMA4C SEMA4C ALX1 ALX1 TBXT TBXT EZH2 EZH2 HES1 HES1 WNT3 WNT3 SOX18 SOX18 JARID2 JARID2 SEMA4A SEMA4A SEMA4B SEMA4B DNMT3L DNMT3L PDCD6 PDCD6 SEMA6B SEMA6B PHF19 PHF19 FRZB FRZB GDNF GDNF EDN1 EDN1 FZD1 FZD1 MSI2 MSI2 FOXA1 FOXA1 PUM1 PUM1 LRP6 LRP6 PTPRC PTPRC BMPR1A BMPR1A SEMA3B SEMA3B GREM1 GREM1 SNAI2 SNAI2 TAL1 TAL1 LIF LIF OSR1 OSR1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (524 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SOX8SRY-box transcription factor 8. (460 aa)
SEMA6CSemaphorin-6C isoform X1; Belongs to the semaphorin family. (966 aa)
CTNNB1Catenin beta 1. (808 aa)
PHF5APHD finger protein 5A. (139 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
FOXO4Forkhead box protein O4 isoform 1. (531 aa)
SEMA4DSemaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (800 aa)
HESX1HESX homeobox 1. (185 aa)
HOXA7Homeobox A7. (234 aa)
GPM6AGlycoprotein M6A. (278 aa)
ZFP36Uncharacterized protein. (372 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (615 aa)
SEMA3CSemaphorin-3C isoform 2; Belongs to the semaphorin family. (751 aa)
TBX2T-box 2 protein. (714 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
HOXB4Homeobox B4. (278 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (421 aa)
OTUD5OTU deubiquitinase 5. (571 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (511 aa)
DMRTA2Doublesex-and mab-3-related transcription factor A2. (535 aa)
MYOCDMyocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa)
PHACTR4Phosphatase and actin regulator. (716 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1399 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
XRCC5X-ray repair cross complementing 5. (1011 aa)
HMGA2Uncharacterized protein. (143 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
SETD6SET domain containing 6, protein lysine methyltransferase. (446 aa)
SEMA5ASemaphorin 5A. (1072 aa)
MLLT3MLLT3 super elongation complex subunit. (624 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (771 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (527 aa)
RESTRE1 silencing transcription factor. (1108 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RADILRap associating with DIL domain. (1192 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
ANXA6Annexin. (672 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
SEMA3DSemaphorin-3D isoform X1; Belongs to the semaphorin family. (777 aa)
BBS12Bardet-Biedl syndrome 12. (714 aa)
PEF1Penta-EF-hand domain containing 1. (334 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
METTL5Methyltransferase like 5. (226 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa)
SRFSerum response factor. (512 aa)
GSCGoosecoid homeobox. (256 aa)
SLC9A1Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. (818 aa)
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
ELL3Elongation factor for RNA polymerase II 3. (374 aa)
SIX1Six homeobox 1. (284 aa)
LOC100359361Uncharacterized protein. (108 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SOX17SRY-box transcription factor 17. (407 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
MSX1Homeobox domain-containing protein. (303 aa)
SFRP2Uncharacterized protein. (294 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
CDX2Homeobox domain-containing protein. (310 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (481 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
HOXD4Homeobox protein Hox-D4. (257 aa)
SEMA3ESemaphorin-3E isoform 1; Belongs to the semaphorin family. (775 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
ZIC3Zic family member 3. (467 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8 isoform X1. (601 aa)
SEMA3GSemaphorin-3G; Belongs to the semaphorin family. (771 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (777 aa)
ZNF281Zinc finger protein 281. (842 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (696 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
SH2B3SH2B adaptor protein 3. (600 aa)
SOX21SRY-box transcription factor 21. (276 aa)
NELFBUncharacterized protein. (757 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
EFNB1Ephrin-B1; Belongs to the ephrin family. (346 aa)
NANOGHomeobox domain-containing protein. (304 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (729 aa)
KLHL12BTB domain-containing protein. (916 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (838 aa)
NRTNNeurturin. (197 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SP7Sp7 transcription factor. (432 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2557 aa)
SEMA6ASemaphorin-6A isoform 1; Belongs to the semaphorin family. (1047 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
SEMA5BSemaphorin 5B. (1126 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
MTF2Metal response element binding transcription factor 2. (599 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (920 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (896 aa)
ALX1ALX homeobox 1. (326 aa)
TBXTT-box transcription factor T. (435 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
HES1Uncharacterized protein. (280 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
SOX18SRY-box transcription factor 18. (389 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1245 aa)
SEMA4ASemaphorin-4A isoform X2; Belongs to the semaphorin family. (791 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (835 aa)
DNMT3LPHD-type domain-containing protein. (382 aa)
PDCD6Programmed cell death 6. (292 aa)
SEMA6BSemaphorin-6B; Belongs to the semaphorin family. (901 aa)
PHF19PHD finger protein 19. (602 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
GDNFGlial cell line-derived neurotrophic factor isoform 1. (211 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
MSI2Musashi RNA binding protein 2. (354 aa)
FOXA1Forkhead box A1. (468 aa)
PUM1Pumilio RNA binding family member 1. (1189 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (747 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
LIFLeukemia inhibitory factor isoform X1. (202 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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