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| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (611 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (541 aa) |
| | ACACB | Biotin carboxylation domain-containing protein. (229 aa) |
| | A0A5G2RBJ3_PIG | Tyrosine-protein kinase receptor. (542 aa) |
| | ACADVL | Acyl-CoA dehydrogenase very long chain. (681 aa) |
| | TSKU | Tsukushi, small leucine rich proteoglycan. (357 aa) |
| | A0A5G2QWB6_PIG | Uncharacterized protein. (979 aa) |
| | ANKRD31 | Ankyrin repeat domain 31. (1501 aa) |
| | CDHR1 | Cadherin-related family member 1 isoform 1. (856 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (201 aa) |
| | STK39 | Serine/threonine kinase 39. (582 aa) |
| | RP1 | RP1 axonemal microtubule associated. (2142 aa) |
| | GRHL1 | Grainyhead like transcription factor 1. (649 aa) |
| | SGIP1 | SH3 domain GRB2 like endophilin interacting protein 1. (848 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa) |
| | BBS12 | Bardet-Biedl syndrome 12. (714 aa) |
| | PTH1R | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. (641 aa) |
| | CIDEA | CIDE-N domain-containing protein. (376 aa) |
| | GRHL3 | Grainyhead like transcription factor 3. (607 aa) |
| | FMO1 | Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (554 aa) |
| | BTBD9 | BTB domain containing 9. (612 aa) |
| | CLRN1 | Clarin 1. (232 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (462 aa) |
| | NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D. (426 aa) |
| | SCX | Basic helix-loop-helix transcription factor scleraxis. (310 aa) |
| | HOMER2 | Homer scaffold protein 2. (343 aa) |
| | PROM1 | Prominin 1. (838 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa) |
| | PPP1R13L | Protein phosphatase 1 regulatory subunit 13 like. (797 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | ADRB2 | Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa) |
| | NDN | Necdin. (325 aa) |
| | NXNL1 | Nucleoredoxin like 1. (214 aa) |
| | TFF1 | P-type domain-containing protein. (86 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2383 aa) |
| | PM20D1 | N-fatty-acyl-amino acid synthase/hydrolase PM20D1. (489 aa) |
| | FTO | FTO_NTD domain-containing protein. (509 aa) |
| | FH | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa) |
| | ADGRV1 | Adhesion G protein-coupled receptor V1. (6313 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa) |
| | CRACD | KIAA1211. (1294 aa) |
| | OCLN | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (533 aa) |
| | LOC110258579 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa) |
| | KMT2A | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4000 aa) |
| | TULP1 | Tubby-like protein; Belongs to the TUB family. (535 aa) |
| | NAPSA | Napsin A aspartic peptidase; Belongs to the peptidase A1 family. (416 aa) |
| | SCNN1G | Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (772 aa) |
| | IL1B-2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa) |
| | SLC11A1 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (538 aa) |
| | HAMP | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (82 aa) |
| | TJP3 | Tight junction protein 3; Belongs to the MAGUK family. (1024 aa) |
| | LRRK1 | Leucine rich repeat kinase 1. (2030 aa) |
| | NKIRAS1 | NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa) |
| | AQP4 | Aquaporin-4 isoform M1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (514 aa) |
| | GCNT2 | Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa) |
| | TFAP2B | Transcription factor AP-2 beta. (469 aa) |
| | GPR55 | G-protein coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | A0A287A514_PIG | NR LBD domain-containing protein. (88 aa) |
| | SLC39A8 | Solute carrier family 39 member 8. (461 aa) |
| | LOC110258582 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa) |
| | MRAP2 | Melanocortin 2 receptor accessory protein 2. (211 aa) |
| | RBP4 | Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Belongs to the calycin superfamily. Lipocalin family. (238 aa) |
| | PIWIL4 | Piwi like RNA-mediated gene silencing 4; Belongs to the argonaute family. (906 aa) |
| | EDN2 | Endothelin 2. (180 aa) |
| | CROCC2 | Ciliary rootlet coiled-coil, rootletin family member 2. (1566 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | SCNN1A | Amiloride-sensitive sodium channel subunit alpha isoform 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa) |
| | CCN2 | CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa) |
| | SLC11A2 | Solute carrier family 11 member 2. (596 aa) |
| | MLLT6 | MLLT6, PHD finger containing. (1093 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1486 aa) |
| | A0A286ZWW0_PIG | AIG1-type G domain-containing protein. (321 aa) |
| | BBS1 | Bardet-Biedl syndrome 1 protein. (593 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (492 aa) |
| | NANOS1 | Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (284 aa) |
| | F2R | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | PASK | PAS domain containing serine/threonine kinase. (1320 aa) |
| | CLCN3 | Chloride channel protein. (866 aa) |
| | CRTC3 | CREB-regulated transcription coactivator 3 isoform a. (619 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa) |
| | CXADR | Uncharacterized protein. (419 aa) |
| | ADD1 | Adducin 1. (786 aa) |
| | BAP1 | BRCA1 associated protein 1. (759 aa) |
| | HOMER1 | Homer scaffold protein 1. (365 aa) |
| | COL3A1 | Collagen alpha-1(III) chain preproprotein. (1471 aa) |
| | WHRN | Whirlin. (920 aa) |
| | YAP1 | Yes associated protein 1. (432 aa) |
| | MEX3C | RNA-binding E3 ubiquitin-protein ligase MEX3C. (655 aa) |
| | ANKRD12 | Ankyrin repeat domain-containing protein 12 isoform X1. (2032 aa) |
| | LOC110258125 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | NXNL2 | Nucleoredoxin like 2. (156 aa) |
| | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa) |
| | VPS54 | Vacuolar protein sorting-associated protein 54 isoform 1. (977 aa) |
| | ILDR2 | Immunoglobulin like domain containing receptor 2. (641 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (674 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | TUB | Tubby-like protein; Belongs to the TUB family. (585 aa) |
| | NCDN | Neurochondrin. (712 aa) |
| | BPIFA1 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] (249 aa) |
| | NOX4 | NADPH oxidase 4. (578 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | ALK | Uncharacterized protein. (1034 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (629 aa) |
| | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (1045 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (209 aa) |
| | OMA1 | Metalloendopeptidase OMA1, mitochondrial. (520 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (727 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (155 aa) |
| | ALDH1A1 | Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa) |
| | HOXA13 | Homeobox A13. (388 aa) |
| | LOC110260322 | Uncharacterized protein. (1023 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (593 aa) |
| | UGCG | UDP-glucose ceramide glucosyltransferase. (394 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa) |
| | RCN3 | Reticulocalbin 3. (335 aa) |
| | TFF2 | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. (165 aa) |
| | CCDC154 | Coiled-coil domain containing 154. (524 aa) |
| | NR1D2 | Uncharacterized protein. (609 aa) |
| | TFF3 | Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). (109 aa) |
| | LOC100523745 | Dimethylaniline monooxygenase [N-oxide-forming]. (578 aa) |
| | AQP2 | Aquaporin-2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (311 aa) |
| | NPHP4 | Nephrocystin 4. (1466 aa) |
| | SCNN1B | Amiloride-sensitive sodium channel subunit beta isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (644 aa) |
| | AIPL1 | Aryl hydrocarbon receptor interacting protein like 1. (328 aa) |
| | HRNR | Uncharacterized protein. (266 aa) |
| | DRAM2 | DNA damage-regulated autophagy modulator protein 2 isoform X1. (266 aa) |
| | LEPR | Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1165 aa) |
| | GATA1 | Erythroid transcription factor. (412 aa) |
| | TRPM2 | Transient receptor potential cation channel subfamily M member 2. (1538 aa) |
| | CDH3 | Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (826 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | ILDR1 | Immunoglobulin like domain containing receptor 1. (595 aa) |
| | TPP1 | Tripeptidyl-peptidase 1 preproprotein. (572 aa) |
| | ALOXE3 | Arachidonate lipoxygenase 3. (710 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (698 aa) |
| | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (289 aa) |
| | MKS1 | MKS transition zone complex subunit 1. (557 aa) |
| | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a. (191 aa) |
| | HCRT | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). (131 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa) |
| | USH1G | USH1 protein network component sans. (461 aa) |
| | LPCAT1 | Lysophosphatidylcholine acyltransferase 1. (534 aa) |
| | SNX10 | Sorting nexin-10 isoform 1. (200 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa) |
| | ADRB3 | Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. (407 aa) |
| | FMO2 | Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa) |
| | FMO4 | Dimethylaniline monooxygenase [N-oxide-forming]. (544 aa) |
| | PRCP | Prolylcarboxypeptidase. (511 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa) |
| | ARRDC3 | Arrestin domain-containing protein 3 isoform a. (414 aa) |
| | COMP | Cartilage oligomeric matrix protein. (756 aa) |
| | CRTC1 | CREB regulated transcription coactivator 1. (647 aa) |
| | ACP5 | Tartrate-resistant acid phosphatase type 5; Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig. (373 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa) |
| | USH1C | USH1 protein network component harmonin. (858 aa) |
| | EXT2 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (688 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa) |
| | SASH3 | SAM and SH3 domain containing 3. (420 aa) |
| | MUC13 | Uncharacterized protein. (537 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (398 aa) |
| | RHO | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa) |
| | VHL | Von Hippel-Lindau disease tumor suppressor isoform 1. (205 aa) |
| | TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa) |
| | HYAL2 | Hyaluronidase. (476 aa) |
| | CRB1 | Crumbs cell polarity complex component 1. (1464 aa) |
| | ADRB1 | Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (516 aa) |
| | LDB1 | LID domain-containing protein. (411 aa) |
| | LIPA | Lipase A, lysosomal acid type. (450 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1462 aa) |
| | CDH23 | Cadherin related 23. (3354 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | HNF1A | Hepatocyte nuclear factor 1-alpha isoform 2. (631 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | AKAP11 | A-kinase anchoring protein 11. (1902 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | LOC100522569 | Complement C1q and tumor necrosis factor-related protein 9A. (333 aa) |
| | TMPRSS11F | Transmembrane protease serine; Belongs to the peptidase S1 family. (438 aa) |
| | CYTL1 | Cytokine like 1. (149 aa) |
| | EPAS1 | Uncharacterized protein. (870 aa) |
| | ATP6V1B1 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (395 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | STARD7 | StAR-related lipid transfer protein 7, mitochondrial. (380 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa) |
| | LOC110258578 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | IL1B2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | UMOD | Uromodulin. (642 aa) |
| | MKKS | McKusick-Kaufman syndrome. (570 aa) |
| | ABCA4 | ATP binding cassette subfamily A member 4. (2320 aa) |
| | TMEM79 | Transmembrane protein 79. (395 aa) |
| | PRDM14 | PR/SET domain 14. (571 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | DBH | Dopamine beta-hydroxylase. (610 aa) |
| | CRB2 | Crumbs cell polarity complex component 2. (1283 aa) |
| | TRIM32 | Tripartite motif containing 32. (652 aa) |
| | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1. (352 aa) |
| | SLC28A2 | Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (704 aa) |
| | USP45 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (817 aa) |
| | SLC35D3 | Solute carrier family 35 member D3. (423 aa) |
| | NOX3 | NADPH oxidase 3. (568 aa) |
| | RPE65 | Retinoid isomerohydrolase RPE65. (533 aa) |
| | KDF1 | Keratinocyte differentiation factor 1. (398 aa) |
| | CROCC | Ciliary rootlet coiled-coil, rootletin. (1966 aa) |
| | BAX | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa) |
| | LSR | Lipolysis stimulated lipoprotein receptor. (598 aa) |
| | IRX3 | Iroquois-class homeodomain protein IRX-3 isoform X2. (502 aa) |
| | CNGB1 | Cyclic nucleotide-binding domain-containing protein. (1165 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (371 aa) |
| | SPATA7 | Spermatogenesis-associated protein 7 isoform 1. (576 aa) |
| | CTSH | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (335 aa) |
| | IL17A | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family. (153 aa) |
| | ADGRF5 | Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1340 aa) |
| | SRF | Serum response factor. (512 aa) |
| | MAK | Male germ cell associated kinase. (692 aa) |
| | POC1B | POC1 centriolar protein B. (478 aa) |
| | BBS10 | Bardet-Biedl syndrome 10. (721 aa) |
| | TNS2 | Tensin 2. (1350 aa) |
| | KRT1 | Keratin 1; Belongs to the intermediate filament family. (624 aa) |
| | AQP6 | Aquaporin-6; Belongs to the MIP/aquaporin (TC 1.A.8) family. (281 aa) |
| | LOC110255300 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | USH2A | Uncharacterized protein. (1544 aa) |
| | SHAS2 | Uncharacterized protein. (553 aa) |
| | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1. (1613 aa) |
| | PLEC | Plectin. (5422 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NMU | Neuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. (173 aa) |
| | TJP2 | Uncharacterized protein; Belongs to the MAGUK family. (1187 aa) |
| | AQP7 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (336 aa) |
| | LCA5 | Lebercilin isoform X1. (700 aa) |
| | KLHL10 | Kelch like family member 10. (608 aa) |
| | NPHP3 | TPR_REGION domain-containing protein. (1368 aa) |
| | TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (1862 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (889 aa) |
| | AQP3 | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] (290 aa) |
| | BMP6 | TGF_BETA_2 domain-containing protein. (537 aa) |
| | FMO3 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) |
| | CLN8 | CLN8 transmembrane ER and ERGIC protein. (416 aa) |
| | PBLD | Phenazine biosynthesis like protein domain containing. (322 aa) |
| | SQSTM1 | Sequestosome 1. (451 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | RAB3D | RAB3D, member RAS oncogene family. (218 aa) |
| | CD7 | Ig-like domain-containing protein. (206 aa) |
| | ABCA12 | ATP binding cassette subfamily A member 12. (2593 aa) |
| | CSF1 | Colony stimulating factor 1. (656 aa) |
| | TRPV1 | Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (832 aa) |
| | SFTPD | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. (386 aa) |
| | PRLH | Prolactin releasing hormone. (87 aa) |
| | LOC110259156 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | COL11A2 | Collagen type XI alpha 2 chain. (1796 aa) |
| | CLDN5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa) |
| | AQP1 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa) |
| | MTF1 | Metal regulatory transcription factor 1. (747 aa) |
| | VSTM4 | V-set and transmembrane domain containing 4. (382 aa) |
| | MBP | Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (295 aa) |
| | IQCB1 | IQ motif containing B1. (600 aa) |
| | LDB2 | LIM domain binding 2. (356 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (924 aa) |
| | ZNF830 | Zinc finger protein 830. (367 aa) |
| | MBL2 | Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. According to some authors, it only binds mannose. (239 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation; Belongs to the IL-7/IL-9 family. (176 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | STRAP | Serine-threonine kinase receptor-associated protein. (350 aa) |
| | BBS4 | Uncharacterized protein. (826 aa) |
| | LOC100519130 | M20_dimer domain-containing protein. (554 aa) |
