(10 nodes) NAD(P)+ nucleosidase activity network (Sus scrofa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	IL1RAPL2	Interleukin 1 receptor accessory protein like 2. (686 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
	CD38	Uncharacterized protein. (286 aa)
	TLR10	TIR domain-containing protein; Belongs to the Toll-like receptor family. (810 aa)
	SARM1	NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (By similarity). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nic [...] (692 aa)
	TLR1	Toll-like receptor 1; Belongs to the Toll-like receptor family. (796 aa)
	TLR6	Toll-like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
	IL1RAPL1	Interleukin 1 receptor accessory protein like 1. (696 aa)
	BST1	Bone marrow stromal cell antigen 1. (302 aa)
	TLR2	Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SARM1	TLR4	ENSSSCP00000025709	ENSSSCP00000060828	NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (By similarity). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nic [...]	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.413
TLR1	TLR10	ENSSSCP00000024245	ENSSSCP00000025971	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.444
TLR1	TLR2	ENSSSCP00000024245	ENSSSCP00000067954	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Belongs to the Toll-like receptor family.	0.998
TLR1	TLR4	ENSSSCP00000024245	ENSSSCP00000060828	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.576
TLR1	TLR6	ENSSSCP00000024245	ENSSSCP00000021244	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Toll-like receptor 6; Belongs to the Toll-like receptor family.	0.976
TLR10	TLR1	ENSSSCP00000025971	ENSSSCP00000024245	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 1; Belongs to the Toll-like receptor family.	0.444
TLR10	TLR2	ENSSSCP00000025971	ENSSSCP00000067954	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Belongs to the Toll-like receptor family.	0.733
TLR10	TLR4	ENSSSCP00000025971	ENSSSCP00000060828	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.447
TLR10	TLR6	ENSSSCP00000025971	ENSSSCP00000021244	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 6; Belongs to the Toll-like receptor family.	0.501
TLR2	TLR1	ENSSSCP00000067954	ENSSSCP00000024245	Toll-like receptor 2; Belongs to the Toll-like receptor family.	Toll-like receptor 1; Belongs to the Toll-like receptor family.	0.998
TLR2	TLR10	ENSSSCP00000067954	ENSSSCP00000025971	Toll-like receptor 2; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.733
TLR2	TLR4	ENSSSCP00000067954	ENSSSCP00000060828	Toll-like receptor 2; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.985
TLR2	TLR6	ENSSSCP00000067954	ENSSSCP00000021244	Toll-like receptor 2; Belongs to the Toll-like receptor family.	Toll-like receptor 6; Belongs to the Toll-like receptor family.	0.999
TLR4	SARM1	ENSSSCP00000060828	ENSSSCP00000025709	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (By similarity). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nic [...]	0.413
TLR4	TLR1	ENSSSCP00000060828	ENSSSCP00000024245	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	Toll-like receptor 1; Belongs to the Toll-like receptor family.	0.576
TLR4	TLR10	ENSSSCP00000060828	ENSSSCP00000025971	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.447
TLR4	TLR2	ENSSSCP00000060828	ENSSSCP00000067954	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	Toll-like receptor 2; Belongs to the Toll-like receptor family.	0.985
TLR4	TLR6	ENSSSCP00000060828	ENSSSCP00000021244	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	Toll-like receptor 6; Belongs to the Toll-like receptor family.	0.963
TLR6	TLR1	ENSSSCP00000021244	ENSSSCP00000024245	Toll-like receptor 6; Belongs to the Toll-like receptor family.	Toll-like receptor 1; Belongs to the Toll-like receptor family.	0.976
TLR6	TLR10	ENSSSCP00000021244	ENSSSCP00000025971	Toll-like receptor 6; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.501