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| | FMC1 | Formation of mitochondrial complex V assembly factor 1 homolog. (113 aa) |
| | OSR1 | Odd-skipped related transcription factor 1. (267 aa) |
| | ESRP2 | Epithelial splicing regulatory protein 2. (717 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (668 aa) |
| | SIX4 | Homeobox domain-containing protein. (785 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa) |
| | PAX6 | Paired box 6. (498 aa) |
| | KRT4 | Keratin 4; Belongs to the intermediate filament family. (533 aa) |
| | ARX | Aristaless related homeobox. (563 aa) |
| | YAP1 | Yes associated protein 1. (432 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) |
| | P14ARF | ANK_REP_REGION domain-containing protein. (159 aa) |
| | STAT1 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa) |
| | PRL | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. (229 aa) |
| | CCL24 | SCY domain-containing protein. (183 aa) |
| | LIMS2 | LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (357 aa) |
| | EGFL7 | EGF like domain multiple 7. (391 aa) |
| | PDCD10 | Programmed cell death protein 10. (212 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | KRIT1 | Uncharacterized protein. (814 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | PAX2 | Paired box 2. (416 aa) |
| | SAV1 | Salvador family WW domain containing protein 1. (433 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa) |
| | TGFBR1 | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa) |
| | AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | CDK6 | Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (638 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (820 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (820 aa) |
| | GPC3 | Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1128 aa) |
| | APOH | Beta-2-glycoprotein 1. (345 aa) |
| | TGM1 | Protein-glutamine gamma-glutamyltransferase K. (826 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) |
| | CD109 | CD109 antigen isoform 1 preproprotein. (1449 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa) |
| | PTCH1 | Protein patched homolog 1 isoform L. (1452 aa) |
| | BRCA2 | Tower domain-containing protein. (1163 aa) |
| | C5AR1 | C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa) |
| | MTA3 | Metastasis associated 1 family member 3. (593 aa) |
| | A4GNT | Alpha-1,4-N-acetylglucosaminyltransferase isoform X1. (340 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | WDR13 | WD repeat domain 13. (587 aa) |
| | ATP5IF1 | ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron i [...] (108 aa) |
| | GDF5 | Growth differentiation factor 5. (499 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa) |
| | ZFP36 | Uncharacterized protein. (372 aa) |
| | CDH3 | Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (826 aa) |
| | ECM1 | Extracellular matrix protein 1. (559 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (889 aa) |
| | THBS4 | Thrombospondin 4. (976 aa) |
| | SYNJ2BP | Synaptojanin 2 binding protein. (164 aa) |
| | IFT80 | Intraflagellar transport 80. (767 aa) |
| | NF1 | Neurofibromin 1. (2847 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa) |
| | CCL11 | C-C motif chemokine. (97 aa) |
| | NGFR | Nerve growth factor receptor. (414 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | HOXA5 | Homeobox domain-containing protein. (381 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa) |
| | TRIM24 | Transcription intermediary factor 1-alpha isoform X1. (1050 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (481 aa) |
| | COL4A3 | Collagen type IV alpha 3 chain. (1669 aa) |
| | PTPRN | Protein tyrosine phosphatase receptor type N. (978 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | ZNF703 | Zinc finger protein 703. (591 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa) |
| | VASH2 | Vasohibin-2 isoform X1. (355 aa) |
| | AQP11 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa) |
| | MEF2C | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa) |
| | SIRT6 | Deacetylase sirtuin-type domain-containing protein. (327 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | VEGFB | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (465 aa) |
| | DEAF1 | Deformed epidermal autoregulatory factor 1 homolog isoform X1. (565 aa) |
| | PLXNB3 | Plexin B3. (1894 aa) |
| | TNMD | Tenomodulin. (317 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa) |
| | MAGED1 | Melanoma-associated antigen D1; Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl- conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression [...] (835 aa) |
| | VEGFD | Vascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family. (354 aa) |
| | IFT57 | Intraflagellar transport 57. (428 aa) |
| | GHRL | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa) |
| | VHL | Von Hippel-Lindau disease tumor suppressor isoform 1. (205 aa) |
| | MST1 | Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa) |
| | JCAD | Junctional cadherin 5 associated. (1378 aa) |
| | KDM5B | Lysine-specific demethylase 5B isoform 2. (1547 aa) |
| | DUSP10 | Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | HMX2 | H6 family homeobox 2. (281 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (669 aa) |
| | NKX2-3 | NK2 homeobox 3. (367 aa) |
| | GDF2 | Growth differentiation factor 2. (427 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | HMGB2 | High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor bindi [...] (210 aa) |
| | CNMD | Chondromodulin. (335 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | ODAM | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family. (275 aa) |
| | SFRP2 | Uncharacterized protein. (294 aa) |
| | FGFBP1 | Fibroblast growth factor-binding protein 1. (237 aa) |
| | XDH | Xanthine dehydrogenase/oxidase. (1336 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa) |
| | ATOH8 | Atonal bHLH transcription factor 8. (315 aa) |
| | SULF2 | Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (906 aa) |
| | PPP1R16B | Protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1. (568 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa) |
| | PROK1 | Prokineticin 1. (105 aa) |
| | WDR77 | WD repeat domain 77. (342 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) |
| | IQGAP3 | IQ motif containing GTPase activating protein 3. (1696 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | SULF1 | Sulfatase 1. (1108 aa) |
| | OSR2 | Odd-skipped related transciption factor 2. (312 aa) |
| | NRARP | NOTCH regulated ankyrin repeat protein. (114 aa) |
| | DBH | Dopamine beta-hydroxylase. (610 aa) |
| | DAB2IP | DAB2 interacting protein. (1196 aa) |
| | RLN2 | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. (182 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (131 aa) |
| | IFT74 | Intraflagellar transport 74. (600 aa) |
| | SIX1 | Six homeobox 1. (284 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (375 aa) |
| | THBS1 | Uncharacterized protein. (1170 aa) |
| | VIP | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (167 aa) |
| | TIE1 | Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa) |
| | FOXE3 | Forkhead box E3. (325 aa) |
| | KDF1 | Keratinocyte differentiation factor 1. (398 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1201 aa) |
| | FUT2 | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (By similarity). Mediates interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen, which is an essential substrate for the final step in the membrane-associated blood group antigen synthesis pathway (By similarity). (340 aa) |
| | BAX | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa) |
| | C5AR2 | Complement component 5a receptor 2. (434 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | HSF4 | Heat shock transcription factor 4. (490 aa) |
| | MARVELD3 | MARVEL domain-containing protein. (390 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (371 aa) |
| | BCL11B | Uncharacterized protein. (888 aa) |
| | VASH1 | Vasohibin 1. (418 aa) |
| | NR2F2 | Nuclear receptor subfamily 2 group F member 2. (414 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (455 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa) |
| | NKX2-8 | NK2 homeobox 8. (241 aa) |
| | PKHD1 | PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4075 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | F1RW79_PIG | Uncharacterized protein. (708 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
| | VDR | Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa) |
| | BMP6 | TGF_BETA_2 domain-containing protein. (537 aa) |
| | TBC1D31 | TBC1 domain family member 31. (1066 aa) |
| | HYAL1 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity); Belongs to the glycosyl hydrolase 56 family. (650 aa) |
| | OVOL1 | Ovo like transcriptional repressor 1. (313 aa) |
| | UHRF1 | Ubiquitin like with PHD and ring finger domains 1. (999 aa) |
| | INTU | Inturned planar cell polarity protein. (937 aa) |
| | IGF2 | Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (583 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | GLI1 | Zinc finger protein GLI1 isoform X1. (1106 aa) |
| | NKX3-1 | Homeobox protein Nkx-3.1 isoform 1. (247 aa) |
| | CCL26 | C-C motif chemokine. (94 aa) |
| | DLX6 | Distal-less homeobox 6. (333 aa) |
| | ATP5F1A | ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (737 aa) |
| | PHOX2B | Paired like homeobox 2B. (314 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | SAAL1 | Serum amyloid A like 1. (490 aa) |
| | MYDGF | Myeloid derived growth factor. (247 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (348 aa) |
| | CDH13 | Uncharacterized protein. (771 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (226 aa) |
| | FGF9 | Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa) |
| | PEX2 | Peroxisomal biogenesis factor 2. (320 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2 isoform a. (399 aa) |
| | FUT1 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. (364 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (1012 aa) |
| | A0A5G2QG99_PIG | Uncharacterized protein. (2082 aa) |
| | FLT1 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa) |
| | MTSS1 | MTSS I-BAR domain containing 1. (766 aa) |
| | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (368 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | HMOX1 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (287 aa) |
| | A0A5G2R6Q7_PIG | Uncharacterized protein. (97 aa) |
| | AGGF1 | Uncharacterized protein. (714 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (611 aa) |
| | ROBO1 | Roundabout guidance receptor 1. (1687 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | ANG | Ribonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family. (177 aa) |
| | WDR48 | WD repeat domain 48. (740 aa) |
| | RUNX2 | Runt-related transcription factor 2 isoform a. (625 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa) |
| | HPN | Hepsin; Belongs to the peptidase S1 family. (449 aa) |
| | GRN | Uncharacterized protein. (656 aa) |
| | MCC | MCC regulator of WNT signaling pathway. (982 aa) |
| | CASK | Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (925 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa) |
| | EMC10 | ER membrane protein complex subunit 10. (273 aa) |
| | STK4 | Serine/threonine kinase 4. (502 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (835 aa) |
| | AIMP1 | Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (335 aa) |
| | HLX | H2.0 like homeobox. (556 aa) |
| | CCR5 | C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | STXBP4 | Syntaxin-binding protein 4 isoform X3. (573 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (434 aa) |
| | ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (527 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | EAF2 | ELL associated factor 2. (273 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa) |
| | B4GALT1 | Beta-1,4-galactosyltransferase 1. (401 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa) |
| | IL26 | Interleukin 26. (171 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1201 aa) |
| | EGR3 | Early growth response protein 3 isoform 1. (387 aa) |
| | MMRN2 | Multimerin 2. (931 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (550 aa) |
| | PDX1 | Homeobox domain-containing protein. (284 aa) |
| | A0A287B8J8_PIG | Uncharacterized protein. (617 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | IRS2 | Insulin receptor substrate 2. (1092 aa) |
| | APELA | Uncharacterized protein. (54 aa) |
| | A0A287B5K4_PIG | Protein kinase domain-containing protein. (62 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | RTN4 | Reticulon. (1199 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | LOC100627967 | Uncharacterized protein. (367 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | KLF9 | Krueppel-like factor 9; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation; Belongs to the Sp1 C2H2-type zinc-finger protein family. (334 aa) |
| | SERPINF1 | Serpin family F member 1; Belongs to the serpin family. (433 aa) |
| | IFT52 | Intraflagellar transport protein 52 homolog isoform X1. (446 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | NODAL | Nodal growth differentiation factor. (316 aa) |
| | STK3 | Serine/threonine kinase 3. (542 aa) |
| | HES1 | Uncharacterized protein. (280 aa) |
| | NME1 | Nucleoside diphosphate kinase. (152 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1 isoform 2. (598 aa) |
| | CDKN1B | p27Kip1. (198 aa) |
| | A0A287AM16_PIG | Uncharacterized protein. (107 aa) |
| | PDCD6 | Programmed cell death 6. (292 aa) |
| | PDCL3 | Phosducin-like protein 3. (240 aa) |
| | DLX5 | Homeobox protein DLX-5. (290 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (855 aa) |
| | BAD | BCL2 associated agonist of cell death. (209 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa) |
| | IRF6 | Interferon regulatory factor 6. (467 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1055 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | APLNR | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa) |
| | GKN3 | Gastrokine-3; May inhibit gastric epithelial cell proliferation. Belongs to the gastrokine family. (170 aa) |
| | PTN | Pleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (262 aa) |
| | SCG2 | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. (616 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | NKX2-6 | NK2 homeobox 6. (299 aa) |
| | PTPRK | Protein tyrosine phosphatase receptor type K. (1554 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | FGF1 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | ZNF304 | Zinc finger protein 304 isoform 2. (661 aa) |
| | PTPRM | Protein tyrosine phosphatase receptor type M. (1507 aa) |
| | SP1 | Transcription factor Sp1 isoform a. (786 aa) |
| | BMP2 | Bone morphogenetic protein 2 preproprotein. (395 aa) |
