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| | LOC100513863 | Uncharacterized protein. (709 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (155 aa) |
| | PROC | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (523 aa) |
| | ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa) |
| | SBNO2 | Strawberry notch homolog 2. (1314 aa) |
| | SERPINE1 | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa) |
| | WFDC1 | WAP four-disulfide core domain 1. (221 aa) |
| | CAMK2N1 | Uncharacterized protein. (158 aa) |
| | TLR10 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (810 aa) |
| | PDE2A | Phosphodiesterase. (1010 aa) |
| | SUCNR1 | Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | SETD4 | SET domain containing 4. (440 aa) |
| | PTGER4 | Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa) |
| | NR1D2 | Uncharacterized protein. (609 aa) |
| | NMI | N-myc and STAT interactor. (307 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (983 aa) |
| | FANCA | FA complementation group A. (1484 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | VAMP8 | V-SNARE coiled-coil homology domain-containing protein. (143 aa) |
| | IFI35 | Interferon induced protein 35. (284 aa) |
| | CTSC | Cathepsin C; Belongs to the peptidase C1 family. (463 aa) |
| | MMP8 | Matrix metallopeptidase 8. (468 aa) |
| | F1SV37_PIG | Uncharacterized protein; Belongs to the peptidase C14A family. (332 aa) |
| | LOC100522887 | Uncharacterized protein; Belongs to the peptidase C14A family. (376 aa) |
| | NLRX1 | NLR family member X1 isoform X1. (975 aa) |
| | HGF | Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa) |
| | DROSHA | Drosha ribonuclease III. (1397 aa) |
| | C1QTNF3 | Complement C1q tumor necrosis factor-related protein 3 isoform b. (319 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1. (349 aa) |
| | SPHK1 | Sphingosine kinase 1 isoform 2. (481 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | CCR7 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa) |
| | GIT1 | GIT ArfGAP 1. (761 aa) |
| | SHPK | Sedoheptulokinase. (478 aa) |
| | BCL6B | BCL6B transcription repressor. (591 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | ASH1L | ASH1 like histone lysine methyltransferase. (2963 aa) |
| | LBP | Uncharacterized protein. (586 aa) |
| | AKNA | AT-hook transcription factor. (1429 aa) |
| | TNFAIP6 | Uncharacterized protein. (277 aa) |
| | ADORA2B | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa) |
| | LGALS2 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known (By similarity). (144 aa) |
| | IL1RL2 | Interleukin 1 receptor like 2. (644 aa) |
| | SEMA7A | Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (615 aa) |
| | ZFP36 | Uncharacterized protein. (372 aa) |
| | PPARA | Uncharacterized protein. (469 aa) |
| | KRT1 | Keratin 1; Belongs to the intermediate filament family. (624 aa) |
| | LRRK2 | Uncharacterized protein. (2501 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (487 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | TTBK1 | Tau tubulin kinase 1. (1305 aa) |
| | DEFB114 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa) |
| | IL16 | Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1338 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | FFAR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (566 aa) |
| | LOC110260995 | Uncharacterized protein. (123 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | NKG7 | Uncharacterized protein. (165 aa) |
| | NLRP7 | NACHT domain-containing protein. (843 aa) |
| | NLRP9 | NACHT, LRR and PYD domains-containing protein 9 isoform X1. (996 aa) |
| | NLRP8 | NLR family pyrin domain containing 8. (1022 aa) |
| | C1QTNF12 | C1q and TNF related 12. (308 aa) |
| | PARK7 | DJ-1 protein. (189 aa) |
| | MAS1 | MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (292 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (231 aa) |
| | C2CD4B | Uncharacterized protein. (372 aa) |
| | RORA | RAR related orphan receptor A. (530 aa) |
| | DUOXA2 | Uncharacterized protein. (360 aa) |
| | DUOXA1 | Dual oxidase maturation factor 1. (337 aa) |
| | TYRO3 | TYRO3 protein tyrosine kinase. (913 aa) |
| | SELENOS | Selenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). (190 aa) |
| | LRFN5 | Leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform X1. (723 aa) |
| | LRRC19 | Leucine-rich repeat-containing protein 19. (369 aa) |
| | IL33 | Interleukin 33. (276 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | PTGES | Microsomal prostaglandin E synthase-1. (153 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (400 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | IDO1 | Uncharacterized protein. (429 aa) |
| | CST7 | Cystatin domain-containing protein. (146 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa) |
| | ZP3 | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm- binding activity by itself but may increase sperm-binding activity of ZPB. (421 aa) |
| | IL1B2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | LOC110258578 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (768 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (295 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa) |
| | PBK | Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (322 aa) |
| | MVK | Mevalonate kinase. (454 aa) |
| | OSM | Oncostatin M. (234 aa) |
| | PLA2G3 | Phospholipase A2 group III. (501 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (414 aa) |
| | FFAR4 | Free fatty acid receptor 4 isoform GPR120-S. (361 aa) |
| | DUSP10 | Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa) |
| | HYAL2 | Hyaluronidase. (476 aa) |
| | TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa) |
| | GHRL | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa) |
| | GHSR | Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa) |
| | BCL6 | B-cell lymphoma 6 protein isoform X1. (706 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa) |
| | VSIG1 | Uncharacterized protein. (1377 aa) |
| | RELA | Transcription factor p65 isoform 1. (573 aa) |
| | DAGLA | Diacylglycerol lipase alpha. (1058 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (470 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | STING1 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa) |
| | NLRP5 | Uncharacterized protein. (1048 aa) |
| | C5orf30 | UNC119-binding protein C5orf30 homolog. (207 aa) |
| | CD81 | Tetraspanin. (258 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (434 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (891 aa) |
| | TNFAIP8L2 | Tumor necrosis factor alpha-induced protein 8-like 2. (184 aa) |
| | A0A5G2R3N8_PIG | Uncharacterized protein. (135 aa) |
| | CD200R1 | Ig-like domain-containing protein. (429 aa) |
| | CD28 | IGv domain-containing protein. (222 aa) |
| | TNFSF4 | Tumor necrosis factor ligand superfamily member 4 isoform X1; Belongs to the tumor necrosis factor family. (182 aa) |
| | NFKBIZ | NFKB inhibitor zeta. (747 aa) |
| | GRN | Uncharacterized protein. (656 aa) |
| | MEFV | Pyrin domain-containing protein. (102 aa) |
| | STK39 | Serine/threonine kinase 39. (582 aa) |
| | NLRP4 | NLR family pyrin domain containing 4. (979 aa) |
| | LDLR | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (201 aa) |
| | ADA | Adenosine deaminase. (409 aa) |
| | TAFA3 | Uncharacterized protein. (133 aa) |
| | TLR2 | Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa) |
| | IL1R1 | Interleukin-1 receptor type 1 isoform 1. (572 aa) |
| | BST1 | Bone marrow stromal cell antigen 1. (302 aa) |
| | CD47 | Leukocyte surface antigen CD47; Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Plays an important role in memory formation and synaptic plasticity in the hippocampus. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeabili [...] (340 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (352 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (770 aa) |
| | PIK3AP1 | Phosphoinositide-3-kinase adaptor protein 1. (905 aa) |
| | RABGEF1 | Uncharacterized protein. (503 aa) |
| | CASP1 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (406 aa) |
| | LPCAT3 | Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (461 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (509 aa) |
| | GPSM3 | G protein signaling modulator 3. (219 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (924 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (621 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | SETD6 | SET domain containing 6, protein lysine methyltransferase. (446 aa) |
| | FANCD2 | Fanconi anemia group D2 protein isoform b. (1459 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (668 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1058 aa) |
| | LOC110259156 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | DNASE1 | Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By s [...] (284 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (447 aa) |
| | C2CD4C | C2 calcium dependent domain containing 4C. (420 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (304 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | F12 | Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (646 aa) |
| | SMPDL3B | Sphingomyelin phosphodiesterase acid like 3B. (406 aa) |
| | IL1RL1 | Interleukin 1 receptor like 1. (573 aa) |
| | GPR17 | G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (339 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (312 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1789 aa) |
| | FCGR1A | Uncharacterized protein. (362 aa) |
| | LOC100517285 | Ig-like domain-containing protein. (313 aa) |
| | DAGLB | Diacylglycerol lipase beta. (691 aa) |
| | AHSG | Alpha-2-HS-glycoprotein. (394 aa) |
| | FUT7 | Alpha-(1,3)-fucosyltransferase 7. (342 aa) |
| | LOC110255300 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (229 aa) |
| | NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D. (426 aa) |
| | SYT11 | Synaptotagmin 11. (438 aa) |
| | FOXP3 | Forkhead box protein P3 isoform a. (475 aa) |
| | CCN4 | WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa) |
| | NDFIP1 | Uncharacterized protein. (254 aa) |
| | PSMB4 | Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (264 aa) |
| | GPR4 | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. (363 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (196 aa) |
| | SPATA2 | Spermatogenesis-associated protein 2. (520 aa) |
| | NLRC3 | NLR family CARD domain-containing protein 3. (1066 aa) |
| | PLA2G10 | Phospholipase A(2). (188 aa) |
| | NFKB1 | Uncharacterized protein. (898 aa) |
| | TNC | Tenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha- V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Belongs to the tenascin family. (2420 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa) |
| | ADIPOQ | C1q domain-containing protein. (332 aa) |
| | LOC100517427 | Uncharacterized protein. (299 aa) |
| | AREL1 | Apoptosis resistant E3 ubiquitin protein ligase 1. (827 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | LOC110258579 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa) |
| | FOXP1 | Forkhead box P1. (692 aa) |
| | RHBDD3 | Rhomboid domain-containing protein 3. (428 aa) |
| | FNDC4 | Fibronectin type III domain containing 4. (233 aa) |
| | PDCD4 | Programmed cell death protein 4 isoform 1. (469 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1274 aa) |
| | IL1B-2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa) |
| | VAMP7 | Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (258 aa) |
| | SNX4 | Sorting nexin 4. (511 aa) |
| | FOXF1 | Forkhead box protein F1. (423 aa) |
| | HAMP | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (82 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (955 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (715 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1532 aa) |
| | CD200 | OX-2 membrane glycoprotein isoform X2. (301 aa) |
| | LETMD1 | LETM1 domain-containing protein 1 isoform a. (360 aa) |
| | CLOCK | Clock circadian regulator. (857 aa) |
| | A0A287A514_PIG | NR LBD domain-containing protein. (88 aa) |
| | LOC110258582 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa) |
| | KARS1 | Lysine--tRNA ligase. (803 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | FEM1A | Protein fem-1 homolog A. (664 aa) |
| | NLRP3 | NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1036 aa) |
| | TREM2 | Ig-like domain-containing protein. (248 aa) |
| | FABP4 | Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2. (604 aa) |
| | MFHAS1 | Malignant fibrous histiocytoma amplified sequence 1. (1062 aa) |
| | MGLL | Monoglyceride lipase. (456 aa) |
| | LACC1 | Uncharacterized protein. (436 aa) |
| | MKRN2 | Putative E3 ubiquitin-protein ligase makorin-2 isoform 1. (488 aa) |
| | BAP1 | BRCA1 associated protein 1. (759 aa) |
| | APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa) |
| | NLRP2 | Uncharacterized protein. (184 aa) |
| | FFAR2 | Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | LOC110258125 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | LOC100152206 | Uncharacterized protein. (319 aa) |
| | CCL24 | SCY domain-containing protein. (183 aa) |
| | IL17RA | Interleukin 17 receptor A. (845 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa) |
| | LOC100737180 | C-X-C motif chemokine 17. (119 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | GGT1 | Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] (617 aa) |
| | NLRP11 | Uncharacterized protein. (734 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (638 aa) |
| | S100A8 | Protein S100; Belongs to the S-100 family. (89 aa) |
| | IL13 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa) |
| | ADAM8 | Disintegrin and metalloproteinase domain-containing protein 8. (835 aa) |
| | AOAH | Acyloxyacyl hydrolase. (575 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (629 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (874 aa) |
| | S100A9 | EF-hand domain-containing protein; Belongs to the S-100 family. (222 aa) |
| | IRF3 | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa) |
| | CD200R1L | Ig-like domain-containing protein. (300 aa) |
| | LTA | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (204 aa) |
| | PGLYRP2 | N-acetylmuramoyl-L-alanine amidase; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. (598 aa) |
| | UFL1 | E3 UFM1-protein ligase 1. (792 aa) |
| | C2CD4D | C2 calcium dependent domain containing 4D. (353 aa) |
