STRINGSTRING
HES5 HES5 ARL2BP ARL2BP MTOR MTOR FYN FYN LYN LYN EFNA1 EFNA1 HAX1 HAX1 ANGPT4 ANGPT4 EPO EPO NCF1 NCF1 F1RGA1_PIG F1RGA1_PIG CTF1 CTF1 MLST8 MLST8 TGFA TGFA STAP1 STAP1 AREG AREG PTK2B PTK2B OSM OSM MIF MIF ERCC6 ERCC6 NEURL1 NEURL1 ADRA2A ADRA2A ABI1 ABI1 GHRL GHRL PAK2 PAK2 CD80 CD80 CLCF1 CLCF1 CD44 CD44 FBXW9 FBXW9 IL5 IL5 IL4 IL4 HPX HPX HGF HGF RELN RELN TNFSF18 TNFSF18 ERBB4 ERBB4 EPHA4 EPHA4 FGF10 FGF10 ISL1 ISL1 LOC100737060 LOC100737060 IL31RA IL31RA UNC119 UNC119 ERBB3 ERBB3 DVL2 DVL2 THBS4 THBS4 CSF2 CSF2 VTN VTN WNT3A WNT3A I3LD26_PIG I3LD26_PIG DOK7 DOK7 FBXW7 FBXW7 GATA1 GATA1 IL6 IL6 GRM5 GRM5 EGF EGF RIPK2 RIPK2 JAK2 JAK2 SEMA4D SEMA4D IL15 IL15 AGT AGT SRC SRC ALK ALK NOX4 NOX4 IL6ST IL6ST SH2D1B SH2D1B ENPP2 ENPP2 HTR2A HTR2A SYK SYK LRP8 LRP8 ARHGEF2 ARHGEF2 EFNA5 EFNA5 ALKAL2 ALKAL2 TNFRSF1A TNFRSF1A LIF LIF IFNG IFNG TAL1 TAL1 TREM2 TREM2 BTC BTC IL11 IL11 PTPN1 PTPN1 GREM1 GREM1 IL23A IL23A IL34 IL34 PTPRC PTPRC LRRK1 LRRK1 SRCIN1 SRCIN1 PDGFB PDGFB NRG1 NRG1 CRLF1 CRLF1 LRP4 LRP4 CASS4 CASS4 FGFR3 FGFR3 IL21 IL21 GHR GHR INS INS PECAM1 PECAM1 IL12B IL12B ADRA1A ADRA1A HES1 HES1 GAS6 GAS6 ALKAL1 ALKAL1 CD74 CD74 TP53 TP53 GH1 GH1 PARP9 PARP9 CD40 CD40 ABL1 ABL1 LOC100517285 LOC100517285 VEGFA VEGFA FCGR1A FCGR1A RICTOR RICTOR BMP6 BMP6 IGF2 IGF2 NOD2 NOD2 IL2 IL2 HBEGF HBEGF DGKQ DGKQ PTPN11 PTPN11 CSF1R CSF1R PRNP PRNP CSF3 CSF3 KIT KIT FGF8 FGF8 BANK1 BANK1 EREG EREG PIBF1 PIBF1 A0A5G2RBJ3_PIG A0A5G2RBJ3_PIG EGFR EGFR PLPP3 PLPP3 IL6R IL6R CNTF CNTF NRP1 NRP1 A0A5G2R1S0_PIG A0A5G2R1S0_PIG HCLS1 HCLS1 LOC110259478 LOC110259478 ITGB3 ITGB3 CD81 CD81 ITGA5 ITGA5 NEDD9 NEDD9 CSPG4 CSPG4 PLCG2 PLCG2
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
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second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HES5Hes family bHLH transcription factor 5. (226 aa)
ARL2BPADP ribosylation factor like GTPase 2 binding protein. (175 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
LYNTyrosine-protein kinase. (512 aa)
EFNA1Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] (205 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools; Belongs to the HAX1 family. (284 aa)
ANGPT4Angiopoietin 4. (503 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa)
NCF1Uncharacterized protein. (378 aa)
F1RGA1_PIGUncharacterized protein. (185 aa)
CTF1Cardiotrophin 1. (202 aa)
MLST8MTOR associated protein, LST8 homolog. (455 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
AREGAmphiregulin long form. (247 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
OSMOncostatin M. (234 aa)
MIFMacrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1462 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (638 aa)
ADRA2AAlpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (465 aa)
ABI1Abl interactor 1 isoform b. (481 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CD80CD80 molecule. (297 aa)
CLCF1Uncharacterized protein. (484 aa)
CD44CD44 molecule (Indian blood group). (767 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (459 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
RELNReelin. (3458 aa)
TNFSF18TNF superfamily member 18. (178 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
EPHA4EPH receptor A4. (986 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
LOC100737060Uncharacterized protein. (2397 aa)
IL31RAInterleukin-31 receptor subunit alpha isoform 2. (717 aa)
UNC119Protein unc-119 homolog A isoform a. (240 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
DVL2Dishevelled segment polarity protein 2. (794 aa)
THBS4Thrombospondin 4. (976 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
I3LD26_PIGUncharacterized protein. (279 aa)
DOK7Protein Dok-7 isoform 4. (600 aa)
FBXW7F-box and WD repeat domain containing 7. (779 aa)
GATA1Erythroid transcription factor. (412 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
SEMA4DSemaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (182 aa)
AGTAngiotensinogen; Belongs to the serpin family. (482 aa)
SRCTyrosine-protein kinase. (559 aa)
ALKUncharacterized protein. (1034 aa)
NOX4NADPH oxidase 4. (578 aa)
IL6STInterleukin 6 signal transducer. (938 aa)
SH2D1BSH2 domain-containing protein. (133 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X3. (1006 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
LRP8LDL receptor related protein 8. (998 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...] (1066 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
ALKAL2ALK and LTK ligand 2. (152 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa)
LIFLeukemia inhibitory factor isoform X1. (202 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
TREM2Ig-like domain-containing protein. (248 aa)
BTCEGF-like domain-containing protein. (342 aa)
IL11Interleukin 11. (199 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
IL23AInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (193 aa)
IL34Interleukin 34. (243 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
LRRK1Leucine rich repeat kinase 1. (2030 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1308 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
NRG1Neuregulin 1. (712 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
LRP4LDL receptor related protein 4. (1918 aa)
CASS4Cas scaffolding protein family member 4; Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity). (810 aa)
FGFR3Fibroblast growth factor receptor. (855 aa)
IL21Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation; Belongs to the IL-1 [...] (160 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. (660 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa)
ADRA1AAlpha-1A adrenergic receptor isoform 1. (466 aa)
HES1Uncharacterized protein. (280 aa)
GAS6Uncharacterized protein. (682 aa)
ALKAL1ALK and LTK ligand 1. (121 aa)
CD74Thyroglobulin type-1 domain-containing protein. (347 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (217 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (847 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
LOC100517285Ig-like domain-containing protein. (313 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa)
FCGR1AUncharacterized protein. (362 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1789 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (583 aa)
NOD2Uncharacterized protein. (1013 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
DGKQDiacylglycerol kinase. (987 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CSF1RColony stimulating factor 1 receptor. (1053 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (257 aa)
CSF3Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. (204 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (780 aa)
EREGEpiregulin. (168 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (782 aa)
A0A5G2RBJ3_PIGTyrosine-protein kinase receptor. (542 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
IL6RInterleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. (491 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity). (619 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
A0A5G2R1S0_PIGUncharacterized protein. (446 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (525 aa)
LOC110259478Uncharacterized protein. (197 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
CD81Tetraspanin. (258 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1057 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (829 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2319 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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