STRINGSTRING
SEMA3B SEMA3B PTN PTN LRP4 LRP4 SKI SKI CTDSP1 CTDSP1 SEMA6B SEMA6B SEMA4B SEMA4B SEMA4A SEMA4A TRIM11 TRIM11 PRTG PRTG WNT3 WNT3 HOOK3 HOOK3 HES1 HES1 SEMA4C SEMA4C NOTCH1 NOTCH1 TP53 TP53 THY1 THY1 SEMA5B SEMA5B RTN4 RTN4 SEMA6A SEMA6A ULK1 ULK1 KIFAP3 KIFAP3 PROX1 PROX1 EPHA7 EPHA7 NOG NOG PCM1 PCM1 HES5 HES5 SEMA4G SEMA4G GDI1 GDI1 SPART SPART SYNGAP1 SYNGAP1 SORL1 SORL1 NKX6-2 NKX6-2 TMEM98 TMEM98 SEMA4F SEMA4F DIP2B DIP2B SEMA5A SEMA5A TNR TNR RTN4R RTN4R DAAM2 DAAM2 NTN1 NTN1 DLL3 DLL3 NFATC4 NFATC4 GORASP1 GORASP1 RAPGEF2 RAPGEF2 LDLR LDLR KIAA0319 KIAA0319 SEMA3D SEMA3D DPYSL5 DPYSL5 SOX11 SOX11 PPP3CA PPP3CA BMP7 BMP7 BRINP1 BRINP1 SEMA6D SEMA6D EPHB2 EPHB2 DRAXIN DRAXIN PSEN1 PSEN1 APPL2 APPL2 REST REST ATOH1 ATOH1 NKX6-1 NKX6-1 RB1 RB1 NF2 NF2 YWHAH YWHAH VAX1 VAX1 SEMA3F SEMA3F IFRD2 IFRD2 SEMA3G SEMA3G RYK RYK DNAJB11 DNAJB11 F2 F2 FSTL4 FSTL4 CDKL3 CDKL3 CTNNA1 CTNNA1 SEMA3E SEMA3E DLX2 DLX2 CCL11 CCL11 NF1 NF1 EFNB3 EFNB3 CDK5 CDK5 TLX2 TLX2 SEMA3C SEMA3C WNT3A WNT3A SEMA7A SEMA7A PTPRS PTPRS SEMA3A SEMA3A NR2E1 NR2E1 PLXNA3 PLXNA3 SEMA4D SEMA4D CTNNB1 CTNNB1 MT3 MT3 PAX6 PAX6 SEMA6C SEMA6C NR1D1 NR1D1 GPR37L1 GPR37L1 LHX2 LHX2 TREM2 TREM2 DLX1 DLX1 WNT5A WNT5A BMPR1A BMPR1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (747 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
LRP4LDL receptor related protein 4. (1918 aa)
SKISKI proto-oncogene. (728 aa)
CTDSP1CTD small phosphatase 1. (261 aa)
SEMA6BSemaphorin-6B; Belongs to the semaphorin family. (901 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (835 aa)
SEMA4ASemaphorin-4A isoform X2; Belongs to the semaphorin family. (791 aa)
TRIM11E3 ubiquitin-protein ligase TRIM11. (468 aa)
PRTGProtogenin. (1200 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
HOOK3Hook microtubule tethering protein 3. (786 aa)
HES1Uncharacterized protein. (280 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (896 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
THY1Thy-1 cell surface antigen. (165 aa)
SEMA5BSemaphorin 5B. (1126 aa)
RTN4Reticulon. (1199 aa)
SEMA6ASemaphorin-6A isoform 1; Belongs to the semaphorin family. (1047 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1176 aa)
KIFAP3Kinesin-associated protein 3 isoform X1. (809 aa)
PROX1Prospero homeobox 1. (737 aa)
EPHA7Ephrin type-A receptor 7 isoform 1. (998 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PCM1Pericentriolar material 1. (2184 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (838 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (526 aa)
SPARTSpartin. (666 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1293 aa)
SORL1Sortilin related receptor 1. (2213 aa)
NKX6-2Homeobox protein Nkx-6.2. (277 aa)
TMEM98Transmembrane protein 98. (226 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (771 aa)
DIP2BDisco interacting protein 2 homolog B. (1575 aa)
SEMA5ASemaphorin 5A. (1072 aa)
TNRTenascin R. (1270 aa)
RTN4RReticulon 4 receptor. (548 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1075 aa)
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (651 aa)
DLL3Delta like canonical Notch ligand 3. (619 aa)
NFATC4Nuclear factor of activated T cells 4. (937 aa)
GORASP1Golgi reassembly stacking protein 1. (499 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1662 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
KIAA0319KIAA0319. (1074 aa)
SEMA3DSemaphorin-3D isoform X1; Belongs to the semaphorin family. (777 aa)
DPYSL5Dihydropyrimidinase-related protein 5 isoform X1. (564 aa)
SOX11Transcription factor SOX. (447 aa)
PPP3CASerine/threonine-protein phosphatase. (523 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
BRINP1BMP/retinoic acid-inducible neural-specific protein 1 isoform X1. (761 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
EPHB2EPH receptor B2. (987 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (416 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
RESTRE1 silencing transcription factor. (1108 aa)
ATOH1Atonal bHLH transcription factor 1. (353 aa)
NKX6-1NK6 homeobox 1. (370 aa)
RB1RB transcriptional corepressor 1. (938 aa)
NF2Neurofibromin 2. (586 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
VAX1Ventral anterior homeobox 1. (333 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (777 aa)
IFRD2Interferon-related developmental regulator 2. (441 aa)
SEMA3GSemaphorin-3G; Belongs to the semaphorin family. (771 aa)
RYKReceptor like tyrosine kinase. (566 aa)
DNAJB11DnaJ homolog subfamily B member 11. (358 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
FSTL4Follistatin like 4. (848 aa)
CDKL3Cyclin dependent kinase like 3. (617 aa)
CTNNA1Catenin alpha 1. (1090 aa)
SEMA3ESemaphorin-3E isoform 1; Belongs to the semaphorin family. (775 aa)
DLX2Distal-less homeobox 2. (328 aa)
CCL11C-C motif chemokine. (97 aa)
NF1Neurofibromin 1. (2847 aa)
EFNB3Ephrin-B3; Belongs to the ephrin family. (340 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
TLX2T cell leukemia homeobox 2. (283 aa)
SEMA3CSemaphorin-3C isoform 2; Belongs to the semaphorin family. (751 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (615 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1946 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (800 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
PLXNA3Plexin A3. (1871 aa)
SEMA4DSemaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
CTNNB1Catenin beta 1. (808 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa)
PAX6Paired box 6. (498 aa)
SEMA6CSemaphorin-6C isoform X1; Belongs to the semaphorin family. (966 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa)
GPR37L1G protein-coupled receptor 37 like 1. (459 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
TREM2Ig-like domain-containing protein. (248 aa)
DLX1Homeobox protein DLX-1 isoform 1. (255 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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