STRINGSTRING
SYK SYK IL6 IL6 MAD2L2 MAD2L2 WNT3A WNT3A STAT6 STAT6 TBX21 TBX21 STAT5B STAT5B STAT5A STAT5A TFRC TFRC RIF1 RIF1 IL10 IL10 IL4 IL4 MEF2C MEF2C CLCF1 CLCF1 SASH3 SASH3 SH3KBP1 SH3KBP1 BCL6 BCL6 TLR9 TLR9 BMI1 BMI1 MIF MIF PCID2 PCID2 TNFSF13B TNFSF13B NSD2 NSD2 MSH2 MSH2 MORN5 MORN5 EXOSC3 EXOSC3 EPHB2 EPHB2 EXOSC6 EXOSC6 CDKN1A CDKN1A CD27 CD27 MMP14 MMP14 NFATC2 NFATC2 TGFB1 TGFB1 SHLD2 SHLD2 TNFSF13 TNFSF13 FCRL3 FCRL3 CD320 CD320 PAXIP1 PAXIP1 TP53BP1 TP53BP1 PPP2R3C PPP2R3C CARD11 CARD11 PTPRC PTPRC INPP5D INPP5D BAD BAD IL21 IL21 TNFRSF13C TNFRSF13C A0A287ANX9_PIG A0A287ANX9_PIG XBP1 XBP1 CD74 CD74 PELI1 PELI1 CD40 CD40 IRS2 IRS2 ATAD5 ATAD5 NOD2 NOD2 LAC_PIG LAC_PIG KMT5B KMT5B IL2 IL2 A0A287BRG1_PIG A0A287BRG1_PIG KMT5C KMT5C CD38 CD38 AKIRIN2 AKIRIN2 IL7 IL7 GPR183 GPR183 NCKAP1L NCKAP1L VAV3 VAV3 BST1 BST1 ADA ADA HMCES HMCES CD28 CD28 SHLD1 SHLD1 CD81 CD81
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TBX21Uncharacterized protein. (535 aa)
STAT5BSignal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa)
STAT5ASignal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
CLCF1Uncharacterized protein. (484 aa)
SASH3SAM and SH3 domain containing 3. (420 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (724 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (706 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa)
BMI1RING-type domain-containing protein. (336 aa)
MIFMacrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa)
PCID2PCI domain-containing protein 2 isoform X1. (399 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (233 aa)
NSD2Histone-lysine N-methyltransferase NSD2 isoform 1. (1338 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (920 aa)
MORN5Uncharacterized protein. (188 aa)
EXOSC3Exosome complex component RRP40 isoform 1. (275 aa)
EPHB2EPH receptor B2. (987 aa)
EXOSC6Exosome component 6. (272 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
CD27CD27. (249 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2. (916 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SHLD2Shieldin complex subunit 2. (907 aa)
TNFSF13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (251 aa)
FCRL3Fc receptor-like protein 3 isoform 1. (729 aa)
CD320CD320 antigen isoform 1. (250 aa)
PAXIP1PAX interacting protein 1. (1030 aa)
TP53BP1Tumor protein p53 binding protein 1. (1931 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
BADBCL2 associated agonist of cell death. (209 aa)
IL21Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation; Belongs to the IL-1 [...] (160 aa)
TNFRSF13CTumor necrosis factor receptor superfamily member 13C. (186 aa)
A0A287ANX9_PIGUncharacterized protein. (472 aa)
XBP1BZIP domain-containing protein. (378 aa)
CD74Thyroglobulin type-1 domain-containing protein. (347 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
ATAD5ATPase family AAA domain containing 5. (1891 aa)
NOD2Uncharacterized protein. (1013 aa)
LAC_PIGIg lambda chain C region. (380 aa)
KMT5BLysine methyltransferase 5B. (915 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
A0A287BRG1_PIGUncharacterized protein. (210 aa)
KMT5CLysine methyltransferase 5C. (455 aa)
CD38Uncharacterized protein. (286 aa)
AKIRIN2Akirin 2. (213 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation; Belongs to the IL-7/IL-9 family. (176 aa)
GPR183G-protein coupled receptor 183 isoform X1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
BST1Bone marrow stromal cell antigen 1. (302 aa)
ADAAdenosine deaminase. (409 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (410 aa)
CD28IGv domain-containing protein. (222 aa)
SHLD1Shieldin complex subunit 1. (276 aa)
CD81Tetraspanin. (258 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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