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| | STARD7 | StAR-related lipid transfer protein 7, mitochondrial. (380 aa) |
| | AQP5 | Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa) |
| | AQP6 | Aquaporin-6; Belongs to the MIP/aquaporin (TC 1.A.8) family. (281 aa) |
| | KRT1 | Keratin 1; Belongs to the intermediate filament family. (624 aa) |
| | VWF | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa) |
| | ANO6 | Anoctamin. (924 aa) |
| | ADTRP | Androgen dependent TFPI regulating protein. (230 aa) |
| | TREML1 | Triggering receptor expressed on myeloid cells like 1. (310 aa) |
| | SRF | Serum response factor. (512 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (371 aa) |
| | LSR | Lipolysis stimulated lipoprotein receptor. (598 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (458 aa) |
| | EPHB2 | EPH receptor B2. (987 aa) |
| | KDF1 | Keratinocyte differentiation factor 1. (398 aa) |
| | EMILIN2 | Elastin microfibril interfacer 2. (1078 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (574 aa) |
| | TYRO3 | TYRO3 protein tyrosine kinase. (913 aa) |
| | THBS1 | Uncharacterized protein. (1170 aa) |
| | CORO2B | Coronin; Belongs to the WD repeat coronin family. (554 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | FZD6 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa) |
| | OPRK1 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. (380 aa) |
| | F5 | Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. (2258 aa) |
| | PEAR1 | Platelet endothelial aggregation receptor 1. (1038 aa) |
| | TMEM79 | Transmembrane protein 79. (395 aa) |
| | STXBP3 | Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (940 aa) |
| | GPAT4 | PlsC domain-containing protein. (457 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa) |
| | UMOD | Uromodulin. (642 aa) |
| | ADRA2B | Alpha-2B adrenergic receptor. (446 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | ATP6V1B1 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (395 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | TMPRSS11F | Transmembrane protease serine; Belongs to the peptidase S1 family. (438 aa) |
| | FGB | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (534 aa) |
| | FGA | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (924 aa) |
| | ANXA5 | Annexin. (321 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (523 aa) |
| | MMRN1 | Multimerin 1. (1220 aa) |
| | HPSE | Heparanase isoform 1 preproprotein. (551 aa) |
| | CSN2 | Beta-casein; Important role in determination of the surface properties of the casein micelles. (231 aa) |
| | CSN3 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. (187 aa) |
| | CPB2 | Carboxypeptidase B2 isoform 1 preproprotein. (423 aa) |
| | AKAP11 | A-kinase anchoring protein 11. (1902 aa) |
| | F10 | Uncharacterized protein. (536 aa) |
| | F7 | Uncharacterized protein. (455 aa) |
| | DMTN | Dematin actin binding protein. (405 aa) |
| | SH2B3 | SH2B adaptor protein 3. (600 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (713 aa) |
| | SERPIND1 | Serpin family D member 1; Belongs to the serpin family. (517 aa) |
| | PLAU | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (442 aa) |
| | NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (638 aa) |
| | ADRA2A | Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (465 aa) |
| | HYAL2 | Hyaluronidase. (476 aa) |
| | P2RY12 | Purinergic receptor P2Y12. (339 aa) |
| | HRG | Uncharacterized protein. (561 aa) |
| | P2RY4 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (365 aa) |
| | F9 | Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (462 aa) |
| | FIBP | Acidic fibroblast growth factor intracellular-binding protein isoform b. (357 aa) |
| | SERPING1 | Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (470 aa) |
| | F2 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa) |
| | EXT2 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (688 aa) |
| | ADM | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. (188 aa) |
| | COMP | Cartilage oligomeric matrix protein. (756 aa) |
| | F2RL1 | Proteinase-activated receptor 2 preproprotein. (397 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa) |
| | NEUROG1 | Neurogenin 1. (246 aa) |
| | ST3GAL4 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4; Belongs to the glycosyltransferase 29 family. (393 aa) |
| | TFPI2 | Tissue factor pathway inhibitor. (232 aa) |
| | KLKB1 | Uncharacterized protein; Belongs to the peptidase S1 family. (643 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1201 aa) |
| | PRSS56 | Serine protease 56; Belongs to the peptidase S1 family. (605 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa) |
| | GHRHR | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. (451 aa) |
| | PPIA | Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (160 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | SLC6A3 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (614 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa) |
| | GP1BA | Platelet glycoprotein Ib alpha polypeptide. (627 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (698 aa) |
| | ALOXE3 | Arachidonate lipoxygenase 3. (710 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | PTPRO | Protein tyrosine phosphatase receptor type O. (1186 aa) |
| | BLOC1S4 | Biogenesis of lysosomal organelles complex 1 subunit 4. (211 aa) |
| | F3 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa) |
| | GATA1 | Erythroid transcription factor. (412 aa) |
| | ADRA2C | Adrenoceptor alpha 2C. (460 aa) |
| | HRNR | Uncharacterized protein. (266 aa) |
| | SCNN1B | Amiloride-sensitive sodium channel subunit beta isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (644 aa) |
| | AQP2 | Aquaporin-2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (311 aa) |
| | VAMP8 | V-SNARE coiled-coil homology domain-containing protein. (143 aa) |
| | FGG | Fibrinogen gamma chain. (454 aa) |
| | I3LLG5_PIG | Uncharacterized protein. (131 aa) |
| | INPP5K | Inositol polyphosphate-5-phosphatase K. (480 aa) |
| | UGCG | UDP-glucose ceramide glucosyltransferase. (394 aa) |
| | CD9 | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...] (226 aa) |
| | LOC110260322 | Uncharacterized protein. (1023 aa) |
| | SERPINE1 | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa) |
| | PROC | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (523 aa) |
| | C1QTNF6 | C1q domain-containing protein. (285 aa) |
| | GP6 | Ig-like domain-containing protein. (319 aa) |
| | CEL | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (585 aa) |
| | SLC7A11 | Solute carrier family 7 member 11. (515 aa) |
| | F8 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. (2133 aa) |
| | GP1BB | Platelet glycoprotein Ib beta chain. (203 aa) |
| | APOH | Beta-2-glycoprotein 1. (345 aa) |
| | F2RL3 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | GP5 | Glycoprotein V platelet. (569 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa) |
| | SLC4A1 | Anion exchange protein. (924 aa) |
| | PAPSS2 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b. (620 aa) |
| | BPIFA1 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] (249 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | ANXA2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa) |
| | PRL | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. (229 aa) |
| | HGFAC | HGF activator. (661 aa) |
| | SCT | Secretin; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the p [...] (135 aa) |
| | DTNBP1 | Uncharacterized protein. (373 aa) |
| | FOXA2 | Hepatocyte nuclear factor 3-beta isoform 1. (463 aa) |
| | MPIG6B | Ig-like domain-containing protein. (328 aa) |
| | F2R | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | RAP2A | Ras-related protein Rap-2a. (183 aa) |
| | F11 | Coagulation factor XI; Belongs to the peptidase S1 family. (623 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa) |
| | MLLT6 | MLLT6, PHD finger containing. (1093 aa) |
| | STXBP1 | Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (609 aa) |
| | SCNN1A | Amiloride-sensitive sodium channel subunit alpha isoform 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa) |
| | MERTK | MER proto-oncogene, tyrosine kinase. (998 aa) |
| | TFAP2B | Transcription factor AP-2 beta. (469 aa) |
| | GP9 | Glycoprotein IX platelet. (173 aa) |
| | PROS1 | Protein S. (702 aa) |
| | AQP4 | Aquaporin-4 isoform M1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa) |
| | ATP7B | Uncharacterized protein. (275 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | AXL | Uncharacterized protein. (871 aa) |
| | RAB27A | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa) |
| | PRKG1 | cGMP-dependent protein kinase. (686 aa) |
| | CELSR2 | Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2917 aa) |
| | ENTPD2 | Ectonucleoside triphosphate diphosphohydrolase 2 isoform 1; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | P2RY2 | P2Y purinoceptor 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP > ATP. (373 aa) |
| | SCNN1G | Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (772 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa) |
| | TSPAN32 | Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (239 aa) |
| | FBLN1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (819 aa) |
| | ENPP4 | Ectonucleotide pyrophosphatase/phosphodiesterase 4. (453 aa) |
| | NPR3 | Atrial natriuretic peptide receptor 3 isoform X1. (535 aa) |
| | AGR2 | Anterior gradient 2, protein disulphide isomerase family member. (206 aa) |
| | CHRM3 | Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. (590 aa) |
| | FOXB1 | Forkhead box protein B1. (325 aa) |
| | C1QTNF1 | C1q and TNF related 1. (273 aa) |
| | NME1 | Nucleoside diphosphate kinase. (152 aa) |
| | USF2 | Upstream transcription factor 2, c-fos interacting. (391 aa) |
| | PDSS2 | Decaprenyl-diphosphate synthase subunit 2 isoform X1; Belongs to the FPP/GGPP synthase family. (394 aa) |
| | TFPI | Tissue factor pathway inhibitor. (303 aa) |
| | TRPV5 | Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (792 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | GAS6 | Uncharacterized protein. (682 aa) |
| | SERPINE2 | SERPIN domain-containing protein; Belongs to the serpin family. (378 aa) |
| | VKORC1 | Vitamin K epoxide reductase complex subunit 1. (163 aa) |
| | F2RL2 | Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha isoform 1. (824 aa) |
| | SHAS2 | Uncharacterized protein. (553 aa) |
| | ANO1 | Anoctamin. (1043 aa) |
| | PLEC | Plectin. (5422 aa) |
| | SERPINF2 | Alpha-2-antiplasmin isoform X2; Belongs to the serpin family. (563 aa) |
| | UBASH3B | Ubiquitin associated and SH3 domain containing B. (638 aa) |
| | AQP7 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (336 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | TIFAB | TIFA inhibitor. (197 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (889 aa) |
| | ZNF385A | Zinc finger protein 385A. (406 aa) |
| | AQP3 | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] (290 aa) |
| | CYBA | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide; Belongs to the p22phox family. (200 aa) |
| | VDR | Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa) |
| | CORO2A | Coronin; Belongs to the WD repeat coronin family. (505 aa) |
| | F12 | Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (646 aa) |
| | LNPK | Lunapark, ER junction formation factor. (429 aa) |
| | ABCA12 | ATP binding cassette subfamily A member 12. (2593 aa) |
| | RAP2B | Ras-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity). (183 aa) |
| | ADAMTS18 | ADAM metallopeptidase with thrombospondin type 1 motif 18. (1223 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | ZBTB7B | Zinc finger and BTB domain-containing protein 7B isoform X1. (543 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | FERMT3 | Fermitin family member 3. (667 aa) |
| | PROCR | Protein C receptor. (262 aa) |
| | THBD | Uncharacterized protein. (529 aa) |
| | ANXA8 | Annexin. (354 aa) |
| | AQP1 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa) |
| | F13B | Coagulation factor XIII B chain. (663 aa) |
| | P2RX1 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (458 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (924 aa) |
| | COPA | Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1241 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (656 aa) |
| | SLC4A5 | Anion exchange protein. (1111 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | HPS5-2 | Uncharacterized protein. (399 aa) |
| | A0A5G2QXZ6_PIG | Protein kinase domain-containing protein. (408 aa) |
| | PLEK | Pleckstrin. (408 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (505 aa) |
| | SERPINC1 | SERPIN domain-containing protein; Belongs to the serpin family. (431 aa) |
| | A0A5G2QWB6_PIG | Uncharacterized protein. (979 aa) |
| | KNG1 | Kininogen 1. (630 aa) |
| | PLG | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa) |
| | ADA | Adenosine deaminase. (409 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (201 aa) |
| | HABP2 | Hyaluronan binding protein 2. (591 aa) |
| | STK39 | Serine/threonine kinase 39. (582 aa) |
| | GRHL1 | Grainyhead like transcription factor 1. (649 aa) |
| | F13A1 | Coagulation factor XIII A chain. (774 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa) |
| | PPBP | Platelet basic protein; Chemoattractant factor for neutrophils. (159 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (835 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (891 aa) |
| | BLOC1S6 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (161 aa) |
| | GRHL3 | Grainyhead like transcription factor 3. (607 aa) |
