STRINGSTRING
SCG2 SCG2 AMCF-II AMCF-II TNFSF11 TNFSF11 EDNRB EDNRB CRKL CRKL NKX2-3 NKX2-3 CCL19 CCL19 ITGA9 ITGA9 IL17RC IL17RC GPR15 GPR15 CD99L2 CD99L2 PRTN3 PRTN3 F2RL1 F2RL1 CXCR5 CXCR5 F1SS05_PIG F1SS05_PIG PPIA PPIA FOXJ1 FOXJ1 NUP85 NUP85 STAT5B STAT5B CCR7 CCR7 TBX21 TBX21 EPX EPX CCL1 CCL1 CCL11 CCL11 CCL2 CCL2 NF1 NF1 ADD2 ADD2 LBP LBP DPEP1 DPEP1 CCL17 CCL17 I3L9Z6_PIG I3L9Z6_PIG CX3CR1 CX3CR1 CCR6 CCR6 UMODL1 UMODL1 PTPRO PTPRO TRPM2 TRPM2 GPRL15 GPRL15 FER FER ELANE ELANE PIK3R1 PIK3R1 ARHGEF5 ARHGEF5 C5AR1 C5AR1 ITGA3 ITGA3 CCL5 CCL5 K7GLG1_PIG K7GLG1_PIG S100A9 S100A9 ADAM8 ADAM8 CCL20 CCL20 SLAMF1 SLAMF1 S100A8 S100A8 ALOX5 ALOX5 ITGB1 ITGB1 LOC100737180 LOC100737180 ITGA6 ITGA6 JAM2 JAM2 MSMP MSMP PPIB PPIB CXCL10 CXCL10 CCL24 CCL24 CCL8 CCL8 SPNS2 SPNS2 FFAR2 FFAR2 SYK SYK LOC100515857 LOC100515857 VAV1 VAV1 CXADR CXADR S1PR1 S1PR1 PAFAH1B1 PAFAH1B1 WDR1 WDR1 CRK CRK PREX1 PREX1 CORO1A CORO1A TGFB2 TGFB2 CKLF CKLF DOCK8 DOCK8 HSD3B7 HSD3B7 LOC100516039 LOC100516039 CCL21 CCL21 ITGA7 ITGA7 MADCAM1 MADCAM1 CRTAM CRTAM EMP2 EMP2 EDN2 EDN2 XG XG A0A287A3F2_PIG A0A287A3F2_PIG CXCL13 CXCL13 CXCL8 CXCL8 MYO1G MYO1G PTN PTN A0A287AB18_PIG A0A287AB18_PIG LOC110257335 LOC110257335 GATA3 GATA3 ITGA4 ITGA4 PDGFB PDGFB SLC12A2 SLC12A2 A0A287AEV6_PIG A0A287AEV6_PIG ITGB7 ITGB7 BCR BCR MSN MSN CNN2 CNN2 PECAM1 PECAM1 LOC100514068 LOC100514068 TRPM4 TRPM4 GAS6 GAS6 MMP9 MMP9 JAML JAML FUT7 FUT7 TAFA4 TAFA4 PLEC PLEC PIKFYVE PIKFYVE A0A287BDP1_PIG A0A287BDP1_PIG CCL14 CCL14 CXCL16 CXCL16 B4GALT1 B4GALT1 EPS8 EPS8 CCL26 CCL26 PODXL2 PODXL2 CSF1 CSF1 CH25H CH25H CCL16 CCL16 SLC37A4 SLC37A4 XG-2 XG-2 CNR2 CNR2 GCNT1 GCNT1 FLT1 FLT1 LGALS3 LGALS3 ROCK1 ROCK1 A0A5G2QPD6_PIG A0A5G2QPD6_PIG RABGEF1 RABGEF1 GPR183 GPR183 NCKAP1L NCKAP1L SELL SELL KIT KIT CSF3R CSF3R TNFSF14 TNFSF14 ITGA1 ITGA1 VAV3 VAV3 CCL4 CCL4 CCL25 CCL25 JAM3 JAM3 F11R F11R ADA ADA PPBP PPBP PLA2G1B PLA2G1B TREM1 TREM1 AIMP1 AIMP1 CHGA CHGA SELP SELP CXCL11 CXCL11 PDE4B PDE4B IRAK4 IRAK4 ANO6 ANO6 NEDD9 NEDD9 IL17A IL17A IL16 IL16 SRP54 SRP54 CCL22 CCL22 LOC110260995 LOC110260995 MCOLN2 MCOLN2 ANXA1 ANXA1 DBH DBH EXT1 EXT1 TRIM55 TRIM55 SELE SELE XCL1 XCL1 SLAMF8 SLAMF8 GBA GBA SBDS SBDS ITGAL ITGAL UMOD UMOD GP2 GP2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCG2Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. (616 aa)
AMCF-IIAlveolar macrophage chemotactic factor 2; Has chemotactic activity for porcine, and in a lesser extent, for human neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (117 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
NKX2-3NK2 homeobox 3. (367 aa)
CCL19C-C motif chemokine. (100 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
IL17RCIL17_R_N domain-containing protein. (511 aa)
GPR15G protein-coupled receptor 15; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CD99L2CD99 molecule like 2. (213 aa)
PRTN3Proteinase 3; Belongs to the peptidase S1 family. (268 aa)
F2RL1Proteinase-activated receptor 2 preproprotein. (397 aa)
CXCR5C-X-C chemokine receptor type 5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
F1SS05_PIGG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (160 aa)
FOXJ1Forkhead box J1. (421 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (684 aa)
STAT5BSignal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa)
CCR7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa)
TBX21Uncharacterized protein. (535 aa)
EPXEosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily. (705 aa)
CCL1C-C motif chemokine. (94 aa)
CCL11C-C motif chemokine. (97 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
NF1Neurofibromin 1. (2847 aa)
ADD2Adducin 2. (725 aa)
LBPUncharacterized protein. (586 aa)
DPEP1Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa)
CCL17C-C motif chemokine. (102 aa)
I3L9Z6_PIGUncharacterized protein. (335 aa)
CX3CR1CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa)
UMODL1Uromodulin like 1. (1360 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1186 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1538 aa)
GPRL15Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). (81 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (271 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1574 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
K7GLG1_PIGUncharacterized protein. (449 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (222 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (835 aa)
CCL20C-C motif chemokine. (153 aa)
SLAMF1Ig-like domain-containing protein. (379 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
ALOX5Arachidonate 5-lipoxygenase. (638 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
LOC100737180C-X-C motif chemokine 17. (119 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
JAM2Junctional adhesion molecule 2. (307 aa)
MSMPBeta-microseminoprotein. (156 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (202 aa)
CXCL10C-X-C motif chemokine. (104 aa)
CCL24SCY domain-containing protein. (183 aa)
CCL8C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)
SPNS2Sphingolipid transporter 2. (561 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
LOC100515857C-C motif chemokine. (132 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CXADRUncharacterized protein. (419 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
WDR1WD repeat-containing protein 1 isoform 1. (606 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (492 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
CKLFChemokine like factor. (113 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (1998 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7. (410 aa)
LOC100516039C-C motif chemokine. (243 aa)
CCL21Putative CCL21 chemokine. (134 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1169 aa)
MADCAM1Mucosal addressin cell adhesion molecule 1 isoform a. (390 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
EDN2Endothelin 2. (180 aa)
XGXg glycoprotein (Xg blood group). (210 aa)
A0A287A3F2_PIGUncharacterized protein. (100 aa)
CXCL13C-X-C motif chemokine. (111 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
MYO1GMyosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (983 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
A0A287AB18_PIGUncharacterized protein. (385 aa)
LOC110257335Golgi phosphoprotein 3 (Coat-protein). (298 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1055 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
SLC12A2Solute carrier family 12 member 2. (1186 aa)
A0A287AEV6_PIGUncharacterized protein. (213 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (882 aa)
BCRBCR activator of RhoGEF and GTPase. (1274 aa)
MSNMoesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. (612 aa)
CNN2Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (396 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
LOC100514068Uncharacterized protein. (257 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1213 aa)
GAS6Uncharacterized protein. (682 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
JAMLJunction adhesion molecule like. (410 aa)
FUT7Alpha-(1,3)-fucosyltransferase 7. (342 aa)
TAFA4TAFA chemokine like family member 4. (140 aa)
PLECPlectin. (5422 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2055 aa)
A0A287BDP1_PIGUncharacterized protein. (48 aa)
CCL14C-C motif chemokine. (99 aa)
CXCL16C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). (342 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (401 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (835 aa)
CCL26C-C motif chemokine. (94 aa)
PODXL2Podocalyxin like 2. (691 aa)
CSF1Colony stimulating factor 1. (656 aa)
CH25HCholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25- hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory eleme [...] (311 aa)
CCL16C-C motif chemokine. (120 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
XG-2Uncharacterized protein. (194 aa)
CNR2Cannabinoid receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
GCNT1Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase. (428 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
LGALS3Galectin. (271 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
A0A5G2QPD6_PIGZP domain-containing protein. (665 aa)
RABGEF1Uncharacterized protein. (503 aa)
GPR183G-protein coupled receptor 183 isoform X1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
SELLSelectin L. (399 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
CSF3RGranulocyte colony-stimulating factor receptor. (848 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform 1. (241 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1175 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
CCL25C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (220 aa)
JAM3Junctional adhesion molecule 3. (360 aa)
F11RUncharacterized protein. (347 aa)
ADAAdenosine deaminase. (409 aa)
PPBPPlatelet basic protein; Chemoattractant factor for neutrophils. (159 aa)
PLA2G1BPhospholipase A2, major isoenzyme; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family. (146 aa)
TREM1Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). (252 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (335 aa)
CHGAp-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. (596 aa)
SELPUncharacterized protein. (671 aa)
CXCL11C-X-C motif chemokine. (129 aa)
PDE4BPhosphodiesterase. (736 aa)
IRAK4Protein kinase domain-containing protein. (459 aa)
ANO6Anoctamin. (924 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (829 aa)
IL17AInterleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family. (153 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1338 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
CCL22C-C motif chemokine. (93 aa)
LOC110260995Uncharacterized protein. (123 aa)
MCOLN2Mucolipin-2 isoform 1. (566 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
DBHDopamine beta-hydroxylase. (610 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
TRIM55Tripartite motif containing 55. (540 aa)
SELEE-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity). Belongs to the selectin/LECAM family. (484 aa)
XCL1Lymphotactin isoform X1. (110 aa)
SLAMF8SLAM family member 8 isoform X1. (295 aa)
GBALysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa)
SBDSRibosome maturation protein SBDS. (250 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1235 aa)
UMODUromodulin. (642 aa)
GP2Pancreatic secretory granule membrane major glycoprotein GP2 isoform 1. (532 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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