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| | INO80 | INO80 complex ATPase subunit. (1566 aa) |
| | APLF | Aprataxin and PNKP like factor. (572 aa) |
| | DMAP1 | DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa) |
| | CCDC117 | Coiled-coil domain containing 117. (279 aa) |
| | SPIDR | DNA repair-scaffolding protein isoform 1. (924 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa) |
| | NABP2 | SOSS complex subunit B1 isoform X1. (211 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (216 aa) |
| | ARID2 | AT-rich interaction domain 2. (1833 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | DBF4 | DBF4-type domain-containing protein. (675 aa) |
| | GREM1 | Gremlin 1, DAN family BMP antagonist. (240 aa) |
| | ZNF112 | Uncharacterized protein. (807 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1931 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | PAXIP1 | PAX interacting protein 1. (1030 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | INO80E | INO80 complex subunit E isoform 1. (244 aa) |
| | A0A286ZVL9_PIG | RING-type domain-containing protein. (137 aa) |
| | EPC1 | Enhancer of polycomb homolog. (841 aa) |
| | ERCC2 | General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (617 aa) |
| | TRIM28 | Tripartite motif containing 28. (868 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (889 aa) |
| | I3LA07_PIG | Uncharacterized protein. (398 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (942 aa) |
| | BRD8 | Bromodomain containing 8. (1236 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1017 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (539 aa) |
| | HDAC10 | Histone deacetylase 10. (671 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (211 aa) |
| | MCRS1 | Microspherule protein 1. (487 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | CCT2 | Chaperonin containing TCP1 subunit 2. (534 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1557 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (763 aa) |
| | EXOSC6 | Exosome component 6. (272 aa) |
| | TERF2 | Telomeric repeat-binding factor 2. (542 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | BAX | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (525 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa) |
| | TFPT | TCF3 fusion partner isoform 1. (253 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | SMOC2 | SPARC related modular calcium binding 2. (613 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1624 aa) |
| | TCP1 | Uncharacterized protein. (559 aa) |
| | KHDC3L | MOEP19 domain-containing protein. (142 aa) |
| | OOEP | Oocyte-expressed protein homolog. (148 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | EXOSC3 | Exosome complex component RRP40 isoform 1. (275 aa) |
| | CIZ1 | CDKN1A interacting zinc finger protein 1. (758 aa) |
| | ENDOG | Endonuclease. (299 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | POGZ | Pogo transposable element with ZNF domain isoform X1. (1412 aa) |
| | BCL7B | BAF chromatin remodeling complex subunit BCL7B. (249 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1778 aa) |
| | NPAS2 | Neuronal PAS domain protein 2. (796 aa) |
| | FAM178B | Uncharacterized protein. (569 aa) |
| | CCT4 | T-complex protein 1 subunit delta. (539 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (920 aa) |
| | NSD2 | Histone-lysine N-methyltransferase NSD2 isoform 1. (1338 aa) |
| | PARM1 | Uncharacterized protein. (302 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (405 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | DBF4B | DBF4 zinc finger B. (640 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1092 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (802 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (566 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa) |
| | USP9X | Putative ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4; Belongs to the peptidase C19 family. (2554 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (164 aa) |
| | A0A287AFM3_PIG | Reverse transcriptase domain-containing protein. (831 aa) |
| | FOXM1 | Forkhead box M1. (766 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (481 aa) |
| | FAM168A | Family with sequence similarity 168 member A. (234 aa) |
| | TMEM161A | Transmembrane protein 161A. (479 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | DNMT3L | PHD-type domain-containing protein. (382 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (163 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (392 aa) |
| | UBE2B | Ubiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | CCT3 | T-complex protein 1 subunit gamma; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. (545 aa) |
| | PRDM7 | PR/SET domain 7. (466 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa) |
| | SELENOK | Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection o [...] (93 aa) |
| | FH | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1084 aa) |
| | INO80D | INO80 complex subunit D. (1028 aa) |
| | NPM2 | Nucleoplasmin domain-containing protein. (260 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (477 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa) |
| | STOML2 | Stomatin like 2. (356 aa) |
| | DERPC | DERPC proline and glycine rich nuclear protein. (643 aa) |
| | OTUD4 | OTU deubiquitinase 4. (1110 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) |
| | TNFSF13 | TNF superfamily member 13; Belongs to the tumor necrosis factor family. (251 aa) |
| | A0A286ZQ36_PIG | Uncharacterized protein. (281 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1003 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (345 aa) |
| | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | SHLD2 | Shieldin complex subunit 2. (907 aa) |
| | LOC100625207 | USP domain-containing protein; Belongs to the peptidase C19 family. (2554 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | YY1 | YY1 transcription factor. (438 aa) |
| | FUS | FUS RNA binding protein. (518 aa) |
| | PPP1R10 | Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] (925 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (903 aa) |
| | NOX4 | NADPH oxidase 4. (578 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | TFRC | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa) |
| | DHX9 | ATP-dependent RNA helicase A. (1384 aa) |
| | FANCB | FA complementation group B. (855 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa) |
| | NRM | Nurim. (203 aa) |
| | DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 tv1. (1012 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (737 aa) |
| | UIMC1 | BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. M [...] (622 aa) |
| | HELQ | Helicase, POLQ like. (1076 aa) |
| | HNRNPD | Heterogeneous nuclear ribonucleoprotein D0 isoform a. (355 aa) |
| | HMGB2 | High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor bindi [...] (210 aa) |
| | MAPKAPK5 | Protein kinase domain-containing protein. (543 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1462 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1316 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1039 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). (327 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (732 aa) |
| | GNL3 | G protein nucleolar 3. (551 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | ACTL6A | Actin-like protein 6A isoform X1; Belongs to the actin family. (429 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | ATRX | ATRX chromatin remodeler. (2486 aa) |
| | MORF4L2 | Mortality factor 4 like 2. (288 aa) |
| | DKC1 | Uncharacterized protein. (521 aa) |
| | CLCF1 | Uncharacterized protein. (484 aa) |
| | SIRT6 | Deacetylase sirtuin-type domain-containing protein. (327 aa) |
| | HDGFL2 | HDGF like 2. (667 aa) |
| | MRNIP | Uncharacterized protein. (216 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1055 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa) |
| | HGF | Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | WRN | WRN RecQ like helicase. (1466 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2466 aa) |
| | POT1 | Protection of telomeres 1. (813 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | TBX21 | Uncharacterized protein. (535 aa) |
| | MBTD1 | Mbt domain containing 1. (715 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (539 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa) |
| | WT1 | Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | EP400 | E1A binding protein p400. (3210 aa) |
| | CCT6A | T-complex protein 1 subunit zeta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). (531 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1169 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ZCWPW1 | Zinc finger CW-type and PWWP domain containing 1. (653 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1349 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (405 aa) |
| | BCAR3 | BCAR3 adaptor protein, NSP family member. (860 aa) |
| | GLI1 | Zinc finger protein GLI1 isoform X1. (1106 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1358 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (265 aa) |
| | KMT5B | Lysine methyltransferase 5B. (915 aa) |
| | A0A287BQB1_PIG | zf-C3HC4 domain-containing protein. (282 aa) |
| | E2F8 | E2F transcription factor 8. (859 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | RFC2 | Replication factor C subunit 2 isoform 1. (352 aa) |
| | KMT5C | Lysine methyltransferase 5C. (455 aa) |
| | RPS3 | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (259 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (489 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (1011 aa) |
| | STPG4 | Sperm-tail PG-rich repeat containing 4. (262 aa) |
| | NVL | Nuclear VCP like. (868 aa) |
| | UBE2V2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (159 aa) |
| | E2F7 | E2F transcription factor 7. (908 aa) |
| | A0A5G2R3X2_PIG | Reverse transcriptase domain-containing protein. (774 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa) |
| | RFC3 | Replication factor C subunit 3 isoform 1. (356 aa) |
| | A0A5G2QSK7_PIG | Reverse transcriptase domain-containing protein. (680 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (260 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (578 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (316 aa) |
| | EREG | Epiregulin. (168 aa) |
| | NEK2 | NIMA related kinase 2. (404 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | A0A5G2RCW4_PIG | Uncharacterized protein. (95 aa) |
| | WDR48 | WD repeat domain 48. (740 aa) |
| | A0A5G2R3D3_PIG | Reverse transcriptase domain-containing protein. (1014 aa) |
| | CDC7 | Cell division cycle 7-related protein kinase isoform X1. (576 aa) |
| | FBXO4 | F-box only protein 4. (387 aa) |
| | A0A5G2QVU0_PIG | Reverse transcriptase domain-containing protein. (742 aa) |
| | HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (410 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (613 aa) |
| | GRHL2 | Grainyhead like transcription factor 2. (626 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1150 aa) |
| | A0A5G2R4M1_PIG | Reverse transcriptase domain-containing protein. (784 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1333 aa) |
| | CD28 | IGv domain-containing protein. (222 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (491 aa) |
| | A0A5G2RES6_PIG | Reverse transcriptase domain-containing protein. (356 aa) |
| | ENSSSCP00000073725 | annotation not available (332 aa) |
| | SHLD1 | Shieldin complex subunit 1. (276 aa) |
| | BCL7C | BAF chromatin remodeling complex subunit BCL7C. (243 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (575 aa) |
| | PARN | Poly(A)-specific ribonuclease. (715 aa) |
| | A0A5G2RGJ5_PIG | Uncharacterized protein. (102 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | CCT7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (548 aa) |
| | NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (325 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1891 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (241 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (192 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | TOX | Thymocyte selection associated high mobility group box. (541 aa) |
| | ANKRD39 | Ankyrin repeat domain 39. (273 aa) |
| | CDT1 | PI-PLC Y-box domain-containing protein. (815 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa) |
| | A0A287B846_PIG | DBF4-type domain-containing protein. (317 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (847 aa) |
| | VPS72 | Vacuolar protein sorting-associated protein 72 homolog isoform 2. (364 aa) |
| | WAS | WASP actin nucleation promoting factor. (500 aa) |
