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AQP5 AQP5 MIP MIP APPL2 APPL2 CTH CTH TRPA1 TRPA1 ALDH9A1 ALDH9A1 AQP10 AQP10 PKD2 PKD2 UPB1 UPB1 MAT1A MAT1A PKD2L1 PKD2L1 CRTC1 CRTC1 ALDH1A3 ALDH1A3 ALDH1A2 ALDH1A2 TDO2 TDO2 APIP APIP ME1 ME1 OSBPL2 OSBPL2 ACACB ACACB CBR4 CBR4 GNMT GNMT KCNJ2 KCNJ2 SHMT2 SHMT2 TK1 TK1 EVL EVL ACOT13 ACOT13 TRPM4 TRPM4 ACACA ACACA VASP VASP SOD2 SOD2 SSBP1 SSBP1 HPRT1 HPRT1 CRYZ CRYZ AQP4 AQP4 THG1L THG1L KCNJ12 KCNJ12 MCOLN1 MCOLN1 SHMT1 SHMT1 CRTC3 CRTC3 USP16 USP16 HSD17B10 HSD17B10 AQP2 AQP2 SAMHD1 SAMHD1 HCN1 HCN1 PCOLCE PCOLCE TRPM2 TRPM2 CRTC2 CRTC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AQP5Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
MIPMajor intrinsic protein of lens fiber; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
CTHCystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] (420 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1145 aa)
ALDH9A14-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. (596 aa)
AQP10Aquaporin-10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (301 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
UPB1Beta-ureidopropionase 1. (393 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (407 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (791 aa)
CRTC1CREB regulated transcription coactivator 1. (647 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (527 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (486 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (241 aa)
ME1NADP-dependent malic enzyme; Belongs to the malic enzymes family. (571 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
ACACBBiotin carboxylation domain-containing protein. (229 aa)
CBR4Carbonyl reductase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
GNMTGlycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity). (334 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (503 aa)
TK1Thymidine kinase. (229 aa)
EVLEnah/Vasp-like. (466 aa)
ACOT13Acyl-CoA thioesterase 13. (141 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1213 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
VASPVasodilator stimulated phosphoprotein. (389 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (485 aa)
SSBP1Single stranded DNA binding protein 1. (163 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (224 aa)
CRYZQuinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). (330 aa)
AQP4Aquaporin-4 isoform M1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
THG1LtRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (298 aa)
KCNJ12ATP-sensitive inward rectifier potassium channel 12 isoform X1. (429 aa)
MCOLN1Mucolipin 1. (663 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (646 aa)
CRTC3CREB-regulated transcription coactivator 3 isoform a. (619 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (823 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa)
AQP2Aquaporin-2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (311 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
HCN1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. (885 aa)
PCOLCEProcollagen C-endopeptidase enhancer 1. (470 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1538 aa)
CRTC2CREB regulated transcription coactivator 2. (758 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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