Your Input: | |
| | LAMTOR1 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | CAV3 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. (151 aa) |
| | ABCG5 | ATP binding cassette subfamily G member 5. (657 aa) |
| | ZBTB20 | Zinc finger and BTB domain containing 20. (751 aa) |
| | APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa) |
| | CYP7A1 | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] (554 aa) |
| | ACOX1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa) |
| | MTCH2 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (334 aa) |
| | OR10J5 | Olfactory receptor family 10 subfamily J member 5. (309 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa) |
| | INSIG1 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (308 aa) |
| | TLCD1 | TLC domain containing 1. (247 aa) |
| | FABP4 | Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | TREM2 | Ig-like domain-containing protein. (248 aa) |
| | GPIHBP1 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (180 aa) |
| | ANGPTL8 | Angiopoietin-like protein 8. (198 aa) |
| | A0A287A514_PIG | NR LBD domain-containing protein. (88 aa) |
| | ADCK1 | AarF domain containing kinase 1. (545 aa) |
| | CES1 | Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] (564 aa) |
| | EPHX2 | Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators. The N- terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12- phosphonooxy-octadec-9Z-enoic acid and 12-phosphon [...] (575 aa) |
| | TTC39A | Tetratricopeptide repeat protein 39A isoform 1. (581 aa) |
| | SOAT2 | O-acyltransferase. (566 aa) |
| | MALRD1 | Uncharacterized protein. (310 aa) |
| | SAR1B | GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). (198 aa) |
| | APOB | Apolipoprotein B-100. (4573 aa) |
| | LIMA1 | LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholest [...] (766 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1131 aa) |
| | ACOX2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa) |
| | USF1 | Upstream transcription factor 1. (317 aa) |
| | ORMDL3 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (173 aa) |
| | RALY | RALY heterogeneous nuclear ribonucleoprotein. (365 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | NFE2L1 | Nuclear factor, erythroid 2 like 1. (766 aa) |
| | TLCD4 | TLC domain-containing protein. (263 aa) |
| | ACOXL | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (708 aa) |
| | G6PC | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa) |
| | A0A287AS79_PIG | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (232 aa) |
| | SURF4 | Surfeit 4. (271 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2383 aa) |
| | USF2 | Upstream transcription factor 2, c-fos interacting. (391 aa) |
| | PLA2G10 | Phospholipase A(2). (188 aa) |
| | TLCD5 | TLC domain containing 5. (245 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | ABHD4 | Abhydrolase domain containing 4. (445 aa) |
| | RTN4 | Reticulon. (1199 aa) |
| | FITM2 | Fat storage-inducing transmembrane protein 2; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization; Belongs to the FIT family. (283 aa) |
| | POLD1 | DNA polymerase. (1152 aa) |
| | TLCD3B | TLC domain containing 3B. (223 aa) |
| | TLCD2 | TLC domain containing 2. (264 aa) |
| | ABCG1 | ATP binding cassette subfamily G member 1. (679 aa) |
| | NR5A2 | Nuclear receptor subfamily 5 group A member 2. (541 aa) |
| | CLN8 | CLN8 transmembrane ER and ERGIC protein. (416 aa) |
| | PNPLA4-2 | Patatin like phospholipase domain containing 4. (256 aa) |
| | APOA4 | Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. (392 aa) |
| | ABHD8 | Abhydrolase domain containing 8. (432 aa) |
| | CYP39A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (461 aa) |
| | ABCA12 | ATP binding cassette subfamily A member 12. (2593 aa) |
| | SLC37A4 | Solute carrier family 37 member 4. (451 aa) |
| | ASGR2 | Asialoglycoprotein receptor 2. (336 aa) |
| | COMMD9 | COMM domain containing 9. (197 aa) |
| | ACOX3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (720 aa) |
| | APOC3 | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (509 aa) |
| | ABCG8 | ATP binding cassette subfamily G member 8. (730 aa) |
| | FUNDC2 | FUN14 domain-containing protein 2; Belongs to the FUN14 family. (215 aa) |
| | RALYL | RALY RNA binding protein like. (306 aa) |
| | GRAMD1B | GRAM domain containing 1B. (878 aa) |
| | LDLRAP1 | Low density lipoprotein receptor adaptor protein 1. (336 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (505 aa) |
| | TSKU | Tsukushi, small leucine rich proteoglycan. (357 aa) |
| | APOA2 | Apolipoprotein A-II preproprotein. (100 aa) |
| | LDLR | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | EHD1 | EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (564 aa) |
| | ORMDL2 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | MYLIP | Myosin regulatory light chain interacting protein. (445 aa) |
| | PNPLA1 | Patatin like phospholipase domain containing 1. (501 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (458 aa) |
| | ANGPTL3 | Fibrinogen C-terminal domain-containing protein. (461 aa) |
| | RORA | RAR related orphan receptor A. (530 aa) |
| | LIPC | Lipase C, hepatic type. (501 aa) |
| | TTC39B | Tetratricopeptide repeat domain 39B. (709 aa) |
| | ABCA1 | Uncharacterized protein. (2261 aa) |
| | ADCK5 | AarF domain containing kinase 5. (591 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa) |
| | LOC100624062 | Uncharacterized protein. (585 aa) |
| | MTTP | Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (894 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | PLA2G12B | Phospholipase A2 group XIIB. (194 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa) |
| | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (825 aa) |
| | ABHD5 | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl- lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of [...] (336 aa) |
| | PNPLA4 | PNPLA domain-containing protein. (320 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (732 aa) |
| | PNPLA2 | Patatin-like phospholipase domain-containing protein 2 isoform X1. (486 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (470 aa) |
| | ANGPTL4 | Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] (412 aa) |
| | SLC25A46 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (205 aa) |
| | ABCG4 | ATP-binding cassette sub-family G member 4 isoform a. (646 aa) |
| | PNPLA8 | Calcium-independent phospholipase A2-gamma isoform 1. (783 aa) |
| | ABCB11 | ATP binding cassette subfamily B member 11. (1375 aa) |
| | ORMDL1 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | NPC1L1 | NPC1-like intracellular cholesterol transporter 1 isoform 2. (1332 aa) |
| | C1QTNF3 | Complement C1q tumor necrosis factor-related protein 3 isoform b. (319 aa) |
| | MED13 | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2173 aa) |
| | TLCD3A | TLC domain containing 3A. (258 aa) |
| | SOAT1 | O-acyltransferase. (549 aa) |
| | GCKR | Glucokinase regulator. (641 aa) |
| | SREBF2 | Sterol regulatory element binding transcription factor 2. (1135 aa) |
| | PCSK9 | Proprotein convertase subtilisin/kexin type 9. (678 aa) |
| | CERT1 | Ceramide transporter 1. (562 aa) |
| | PLSCR3 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (297 aa) |
| | LCAT | Phosphatidylcholine-sterol acyltransferase. (471 aa) |
| | NR1D2 | Uncharacterized protein. (609 aa) |
| | NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa) |
| | RCN3 | Reticulocalbin 3. (335 aa) |
| | PNPLA3 | Patatin like phospholipase domain containing 3. (441 aa) |
| | TMEM97 | Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (177 aa) |
| | LIPG | Lipase G, endothelial type. (501 aa) |
| | NPC1 | NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular traf [...] (1276 aa) |
| | A0A5G2R3N8_PIG | Uncharacterized protein. (135 aa) |
| | DGAT1 | Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (665 aa) |
