STRINGSTRING
PKDCC PKDCC SOS1 SOS1 MSX1 MSX1 TBX3 TBX3 VAX1 VAX1 CSRNP1 CSRNP1 EPHB3 EPHB3 BCOR BCOR SHH SHH MEOX2 MEOX2 GLI3 GLI3 CPLANE1 CPLANE1 WFIKKN2 WFIKKN2 WNT11 WNT11 TBX2 TBX2 WNT3A WNT3A MMP25 MMP25 BNC2 BNC2 TIPARP TIPARP SATB2 SATB2 TMEM107 TMEM107 JAG2 JAG2 TGFB3 TGFB3 TGFBR1 TGFBR1 DLG1 DLG1 PAK1IP1 PAK1IP1 LEF1 LEF1 WFIKKN1 WFIKKN1 OSR1 OSR1 COL2A1 COL2A1 INSIG1 INSIG1 LOC110257970 LOC110257970 ALX4 ALX4 PRRX1 PRRX1 WNT5A WNT5A LRRC32 LRRC32 BMPR1A BMPR1A PLEKHA1 PLEKHA1 INSIG2 INSIG2 IRF6 IRF6 FZD2 FZD2 DLX5 DLX5 ITGB8 ITGB8 PDGFRA PDGFRA SNAI1 SNAI1 INHBA INHBA TCF21 TCF21 TFAP2A TFAP2A FOXF2 FOXF2 SGPL1 SGPL1 WNT9B WNT9B INTU INTU HAND2 HAND2 LOC100737265 LOC100737265 DLX6 DLX6 A0A5G2R9S5_PIG A0A5G2R9S5_PIG LOXL3 LOXL3 ACVR2B ACVR2B FRAS1 FRAS1 TSHZ1 TSHZ1 ARID5B ARID5B DLG2 DLG2 GDF11 GDF11 DHRS3 DHRS3 EPHB2 EPHB2 TBC1D32 TBC1D32 SMAD4 SMAD4 FOXE1 FOXE1 OSR2 OSR2 MSC MSC CHD7 CHD7 NPRL3 NPRL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
MSX1Homeobox domain-containing protein. (303 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
VAX1Ventral anterior homeobox 1. (333 aa)
CSRNP1Cysteine/serine-rich nuclear protein 1 isoform b. (588 aa)
EPHB3Ephrin type-B receptor 3. (999 aa)
BCORANK_REP_REGION domain-containing protein. (693 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
MEOX2Homeobox domain-containing protein. (303 aa)
GLI3GLI family zinc finger 3. (1586 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3098 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (580 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
TBX2T-box 2 protein. (714 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
MMP25Matrix metallopeptidase 25. (566 aa)
BNC2Basonuclin 2. (1085 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (657 aa)
SATB2DNA-binding protein SATB. (733 aa)
TMEM107Transmembrane protein 107 isoform 2. (140 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1371 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
PAK1IP1PAK1 interacting protein 1. (370 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (308 aa)
LOC110257970ANK_REP_REGION domain-containing protein. (1679 aa)
ALX4ALX homeobox 4. (406 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LRRC32Leucine rich repeat containing 32. (688 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PLEKHA1Pleckstrin homology domain-containing family A member 1 isoform X3. (402 aa)
INSIG2Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity). (225 aa)
IRF6Interferon regulatory factor 6. (467 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
DLX5Homeobox protein DLX-5. (290 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (722 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa)
TCF21Transcription factor 21. (179 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
FOXF2Forkhead box F2. (443 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (609 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
INTUInturned planar cell polarity protein. (937 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
LOC100737265Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
DLX6Distal-less homeobox 6. (333 aa)
A0A5G2R9S5_PIGSCHIP-1 domain-containing protein. (485 aa)
LOXL3Lysyl oxidase like 3. (814 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4013 aa)
TSHZ1Teashirt zinc finger homeobox 1. (1101 aa)
ARID5BAT-rich interaction domain 5B. (1194 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
GDF11Growth/differentiation factor 11 preproprotein. (404 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
EPHB2EPH receptor B2. (987 aa)
TBC1D32Protein broad-minded isoform X1. (1300 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
FOXE1Forkhead box E1. (373 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
MSCMusculin. (201 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2863 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (611 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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