STRINGSTRING
GNAT2 GNAT2 HIPK1 HIPK1 CHD7 CHD7 CALB1 CALB1 LAMC3 LAMC3 CRB2 CRB2 NR2E3 NR2E3 TBC1D32 TBC1D32 RPE65 RPE65 BAX BAX RPGRIP1 RPGRIP1 NRL NRL MDM1 MDM1 GDF11 GDF11 ACVRL1 ACVRL1 LRP5 LRP5 TCIRG1 TCIRG1 USH1C USH1C GRM6 GRM6 PDE6A PDE6A MFRP MFRP NEUROD1 NEUROD1 IHH IHH LPCAT1 LPCAT1 SOX9 SOX9 STAT3 STAT3 MED1 MED1 POU4F2 POU4F2 FJX1 FJX1 RP1L1 RP1L1 HCN1 HCN1 GPM6A GPM6A VSX1 VSX1 CDON CDON NPHP4 NPHP4 ATOH7 ATOH7 HIPK2 HIPK2 BMPR1B BMPR1B PTF1A PTF1A DLL1 DLL1 ARHGEF15 ARHGEF15 RHOJ RHOJ NR2E1 NR2E1 IGFN1 IGFN1 DCX DCX RS1 RS1 SMARCA4 SMARCA4 LHX1 LHX1 TUB TUB IMPG2 IMPG2 RPGRIP1L RPGRIP1L PAX6 PAX6 RD3 RD3 SMARCD3 SMARCD3 SOX8 SOX8 RDH13 RDH13 LHX2 LHX2 LOC110258874 LOC110258874 PTPRM PTPRM PRPH2 PRPH2 RPL24 RPL24 SCAPER SCAPER MERTK MERTK TFAP2B TFAP2B NTRK2 NTRK2 NEUROD4 NEUROD4 MEGF11 MEGF11 CLIC4 CLIC4 TULP1 TULP1 MYPN MYPN HES1 HES1 PDE6B PDE6B LAMB2 LAMB2 PDGFRA PDGFRA ZNF513 ZNF513 NOTCH1 NOTCH1 PROM1 PROM1 THY1 THY1 HIF1A HIF1A ROM1 ROM1 PROX1 PROX1 TSPAN12 TSPAN12 TTC8 TTC8 CLN8 CLN8 CYP1B1 CYP1B1 AHI1 AHI1 TTN TTN THRB THRB AGTPBP1 AGTPBP1 GNAT1 GNAT1 FZD4 FZD4 JMJD6 JMJD6 VSTM4 VSTM4 A0A5G2QUL4_PIG A0A5G2QUL4_PIG NAGLU NAGLU SLC4A5 SLC4A5 PFDN5 PFDN5 CABP4 CABP4 ACHE ACHE BBS4 BBS4 ACVR2B ACVR2B MFSD2A MFSD2A CLCN2 CLCN2 CNTF CNTF RP1 RP1 BMPR2 BMPR2 RORB RORB ZHX2 ZHX2 MAN2A1 MAN2A1 SDK1 SDK1 CRB1 CRB1 PDE6C PDE6C NF2 NF2 FOXN4 FOXN4 VAX2 VAX2 BARHL2 BARHL2 DSCAM DSCAM ACTL6A ACTL6A RHO RHO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAT2G protein subunit alpha transducin 2. (354 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform 1. (1210 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2863 aa)
CALB1Calbindin 1. (261 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
CRB2Crumbs cell polarity complex component 2. (1283 aa)
NR2E3Nuclear receptor subfamily 2 group E member 3. (413 aa)
TBC1D32Protein broad-minded isoform X1. (1300 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
RPGRIP1RPGR interacting protein 1. (939 aa)
NRLNeural retina leucine zipper. (237 aa)
MDM1Mdm1 nuclear protein. (655 aa)
GDF11Growth/differentiation factor 11 preproprotein. (404 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa)
USH1CUSH1 protein network component harmonin. (858 aa)
GRM6Glutamate metabotropic receptor 6. (872 aa)
PDE6APhosphodiesterase. (866 aa)
MFRPMembrane frizzled-related protein. (568 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (534 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
POU4F2POU domain protein. (408 aa)
FJX1Four-jointed box kinase 1. (437 aa)
RP1L1Uncharacterized protein. (1203 aa)
HCN1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. (885 aa)
GPM6AGlycoprotein M6A. (278 aa)
VSX1Visual system homeobox 1. (364 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
NPHP4Nephrocystin 4. (1466 aa)
ATOH7Atonal bHLH transcription factor 7. (155 aa)
HIPK2Homeodomain interacting protein kinase 2. (1208 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (844 aa)
RHOJUncharacterized protein. (213 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
IGFN1Uncharacterized protein. (1253 aa)
DCXDoublecortin. (365 aa)
RS1Retinoschisin 1. (228 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1647 aa)
LHX1LIM homeobox 1. (436 aa)
TUBTubby-like protein; Belongs to the TUB family. (585 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1244 aa)
RPGRIP1LProtein fantom isoform X1. (1270 aa)
PAX6Paired box 6. (498 aa)
RD3Retinal degeneration 3, GUCY2D regulator. (195 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (548 aa)
SOX8SRY-box transcription factor 8. (460 aa)
RDH13Retinol dehydrogenase 13 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (334 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
LOC110258874Fork-head domain-containing protein. (493 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1507 aa)
PRPH2Peripherin 2. (346 aa)
RPL24Ribosomal protein L24. (217 aa)
SCAPERS phase cyclin A-associated protein in the endoplasmic reticulum isoform X1. (1408 aa)
MERTKMER proto-oncogene, tyrosine kinase. (998 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (535 aa)
MYPNMyopalladin isoform a. (1320 aa)
HES1Uncharacterized protein. (280 aa)
PDE6BPhosphodiesterase. (856 aa)
LAMB2Laminin subunit beta-2. (1881 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
ZNF513Zinc finger protein 513. (572 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
PROM1Prominin 1. (838 aa)
THY1Thy-1 cell surface antigen. (165 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
ROM1Retinal outer segment membrane protein 1. (351 aa)
PROX1Prospero homeobox 1. (737 aa)
TSPAN12Tetraspanin. (305 aa)
TTC8Tetratricopeptide repeat domain 8. (587 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (416 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
AHI1Abelson helper integration site 1. (1114 aa)
TTNUncharacterized protein. (563 aa)
THRBThyroid hormone receptor beta isoform X2. (476 aa)
AGTPBP1ATP/GTP binding protein 1. (1227 aa)
GNAT1Guanine nucleotide-binding protein G(T) subunit alpha-1 isoform X2. (350 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (413 aa)
VSTM4V-set and transmembrane domain containing 4. (382 aa)
A0A5G2QUL4_PIGUncharacterized protein. (536 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (744 aa)
SLC4A5Anion exchange protein. (1111 aa)
PFDN5Prefoldin subunit 5. (109 aa)
CABP4Calcium binding protein 4. (311 aa)
ACHEAcetylcholinesterase (Cartwright blood group); Belongs to the type-B carboxylesterase/lipase family. (765 aa)
BBS4Uncharacterized protein. (826 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (541 aa)
CLCN2Chloride channel protein. (1026 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity). (619 aa)
RP1RP1 axonemal microtubule associated. (2142 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
RORBRAR related orphan receptor B. (548 aa)
ZHX2Zinc fingers and homeoboxes 2. (827 aa)
MAN2A1Alpha-mannosidase. (1164 aa)
SDK1Sidekick cell adhesion molecule 1. (2141 aa)
CRB1Crumbs cell polarity complex component 1. (1464 aa)
PDE6CPhosphodiesterase. (859 aa)
NF2Neurofibromin 2. (586 aa)
FOXN4Fork-head domain-containing protein. (517 aa)
VAX2Ventral anterior homeobox 2. (288 aa)
BARHL2BarH like homeobox 2. (384 aa)
DSCAMDS cell adhesion molecule. (2008 aa)
ACTL6AActin-like protein 6A isoform X1; Belongs to the actin family. (429 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.