(19 nodes) Wnt signaling pathway, planar cell polarity pathway network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	DVL1	Dishevelled segment polarity protein 1. (700 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (244 aa)
	FZD6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
	VANGL2	Vang-like protein. (521 aa)
	SFRP2	Uncharacterized protein. (294 aa)
	RYK	Receptor like tyrosine kinase. (566 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
	GRHL3	Grainyhead like transcription factor 3. (607 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3320 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	MED12	Mediator complex subunit 12. (2187 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	GPC3	Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
	DVL2	Dishevelled segment polarity protein 2. (794 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CELSR1	DVL1	ENSSSCP00000059338	ENSSSCP00000003625	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 1.	0.654
CELSR1	DVL2	ENSSSCP00000059338	ENSSSCP00000019910	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 2.	0.810
CELSR1	DVL3	ENSSSCP00000059338	ENSSSCP00000025794	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Segment polarity protein dishevelled homolog DVL-3 isoform X1.	0.487
CELSR1	FZD3	ENSSSCP00000059338	ENSSSCP00000034313	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.758
CELSR1	FZD6	ENSSSCP00000059338	ENSSSCP00000006462	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.771
CELSR1	GRHL3	ENSSSCP00000059338	ENSSSCP00000074183	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Grainyhead like transcription factor 3.	0.469
CELSR1	PTK7	ENSSSCP00000059338	ENSSSCP00000001804	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.716
CELSR1	SFRP1	ENSSSCP00000059338	ENSSSCP00000029500	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Secreted frizzled-related protein 1.	0.442
CELSR1	VANGL2	ENSSSCP00000059338	ENSSSCP00000006806	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.827
DVL1	CELSR1	ENSSSCP00000003625	ENSSSCP00000059338	Dishevelled segment polarity protein 1.	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	0.654
DVL1	DVL2	ENSSSCP00000003625	ENSSSCP00000019910	Dishevelled segment polarity protein 1.	Dishevelled segment polarity protein 2.	0.955
DVL1	DVL3	ENSSSCP00000003625	ENSSSCP00000025794	Dishevelled segment polarity protein 1.	Segment polarity protein dishevelled homolog DVL-3 isoform X1.	0.777
DVL1	FZD2	ENSSSCP00000003625	ENSSSCP00000042537	Dishevelled segment polarity protein 1.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.946
DVL1	FZD3	ENSSSCP00000003625	ENSSSCP00000034313	Dishevelled segment polarity protein 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.956
DVL1	FZD6	ENSSSCP00000003625	ENSSSCP00000006462	Dishevelled segment polarity protein 1.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.957
DVL1	PTK7	ENSSSCP00000003625	ENSSSCP00000001804	Dishevelled segment polarity protein 1.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.468
DVL1	RYK	ENSSSCP00000003625	ENSSSCP00000012409	Dishevelled segment polarity protein 1.	Receptor like tyrosine kinase.	0.502
DVL1	SFRP1	ENSSSCP00000003625	ENSSSCP00000029500	Dishevelled segment polarity protein 1.	Secreted frizzled-related protein 1.	0.591
DVL1	VANGL2	ENSSSCP00000003625	ENSSSCP00000006806	Dishevelled segment polarity protein 1.	Vang-like protein.	0.980
DVL1	WNT11	ENSSSCP00000003625	ENSSSCP00000019221	Dishevelled segment polarity protein 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.713