STRINGSTRING
EDN2 EDN2 TNFSF14 TNFSF14 ITGA1 ITGA1 CCRL2 CCRL2 CXCL12 CXCL12 VAV3 VAV3 CCL4 CCL4 PIP5K1A PIP5K1A CCL25 CCL25 NRP1 NRP1 PPBP PPBP PLA2G1B PLA2G1B TREM1 TREM1 CHGA CHGA CCR5 CCR5 CXCL11 CXCL11 PDE4B PDE4B CCL21 CCL21 ANO6 ANO6 IL16 IL16 SRP54 SRP54 CCL22 CCL22 LOC110260995 LOC110260995 EPHA2 EPHA2 ANXA1 ANXA1 CCN3 CCN3 XCL1 XCL1 SLAMF8 SLAMF8 RAB13 RAB13 KIT KIT NCKAP1L NCKAP1L GPR183 GPR183 TPBG TPBG A0A5G2QL47_PIG A0A5G2QL47_PIG ACKR2 ACKR2 PARVA PARVA SBDS SBDS CXCL8 CXCL8 AMCF-II AMCF-II TNFSF11 TNFSF11 EDNRB EDNRB HMGB2 HMGB2 CRKL CRKL CCL19 CCL19 CCL27 CCL27 PRKCQ PRKCQ CXCR6 CXCR6 CCR1 CCR1 IL17RC IL17RC ACKR4 ACKR4 PLXNB3 PLXNB3 AZU1 AZU1 LOX LOX CXCL14 CXCL14 PDGFRB PDGFRB CXCR5 CXCR5 HGF HGF F1SS05_PIG F1SS05_PIG ACKR3 ACKR3 PPIA PPIA CCL28 CCL28 NUP85 NUP85 CCR7 CCR7 CCL3L1 CCL3L1 CCL1 CCL1 CCL11 CCL11 CCL2 CCL2 LBP LBP DPEP1 DPEP1 BIN2 BIN2 CCL17 CCL17 I3L9Z6_PIG I3L9Z6_PIG CX3CR1 CX3CR1 CCR6 CCR6 PTPRO PTPRO TRPM2 TRPM2 EPHB1 EPHB1 GPRL15 GPRL15 CCR8 CCR8 CCR2 CCR2 DEFB1-2 DEFB1-2 XCR1 XCR1 ARHGEF5 ARHGEF5 F1RSX1_PIG F1RSX1_PIG ELMO2 ELMO2 C5AR1 C5AR1 CCL5 CCL5 S100A9 S100A9 CXCR3 CXCR3 GAB1 GAB1 ADAM8 ADAM8 CCL20 CCL20 SLAMF1 SLAMF1 S100A8 S100A8 ALOX5 ALOX5 LOC100737180 LOC100737180 AGTR1 AGTR1 MSMP MSMP PPIB PPIB CXCL10 CXCL10 CCL24 CCL24 CCL8 CCL8 FFAR2 FFAR2 SYK SYK LOC100515857 LOC100515857 CCR4 CCR4 LEF1 LEF1 VAV1 VAV1 CXADR CXADR S1PR1 S1PR1 CRK CRK PREX1 PREX1 CORO1A CORO1A TGFB2 TGFB2 A0A286ZVM6_PIG A0A286ZVM6_PIG CKLF CKLF HSD3B7 HSD3B7 LOC100516039 LOC100516039 LGALS3 LGALS3 FLT1 FLT1 CNR2 CNR2 ARRB2 ARRB2 HBEGF HBEGF CCR10 CCR10 SLC37A4 SLC37A4 CCL16 CCL16 CH25H CH25H CXCR4 CXCR4 CCL26 CCL26 LOC110257049 LOC110257049 DOCK4 DOCK4 A0A287BIH2_PIG A0A287BIH2_PIG HOXB9 HOXB9 CXCL16 CXCL16 VEGFA VEGFA CCL14 CCL14 PRKCD PRKCD PIKFYVE PIKFYVE EGR3 EGR3 PLEC PLEC CORO1B CORO1B TAFA4 TAFA4 RHOG RHOG JAML JAML BCAR1 BCAR1 CXCL2 CXCL2 A0A287AYR7_PIG A0A287AYR7_PIG GAS6 GAS6 PDGFRA PDGFRA LPAR1 LPAR1 TRPM4 TRPM4 A0A287ATC1_PIG A0A287ATC1_PIG LOC100514068 LOC100514068 CXCL9 CXCL9 ARHGEF16 ARHGEF16 NR4A1 NR4A1 SLC12A2 SLC12A2 PDGFB PDGFB PTN PTN SCG2 SCG2 CXCL13 CXCL13 CSF3R CSF3R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDN2Endothelin 2. (180 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform 1. (241 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1175 aa)
CCRL2Chemokine C-C motif receptor-like 2; Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine- triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity). (350 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa)
CCL25C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (220 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
PPBPPlatelet basic protein; Chemoattractant factor for neutrophils. (159 aa)
PLA2G1BPhospholipase A2, major isoenzyme; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family. (146 aa)
TREM1Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). (252 aa)
CHGAp-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. (596 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (361 aa)
CXCL11C-X-C motif chemokine. (129 aa)
PDE4BPhosphodiesterase. (736 aa)
CCL21Putative CCL21 chemokine. (134 aa)
ANO6Anoctamin. (924 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1338 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
CCL22C-C motif chemokine. (93 aa)
LOC110260995Uncharacterized protein. (123 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
CCN3Cellular communication network factor 3. (398 aa)
XCL1Lymphotactin isoform X1. (110 aa)
SLAMF8SLAM family member 8 isoform X1. (295 aa)
RAB13Uncharacterized protein. (203 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
GPR183G-protein coupled receptor 183 isoform X1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
TPBGTrophoblast glycoprotein. (419 aa)
A0A5G2QL47_PIGUncharacterized protein. (116 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (385 aa)
PARVAParvin alpha. (373 aa)
SBDSRibosome maturation protein SBDS. (250 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
AMCF-IIAlveolar macrophage chemotactic factor 2; Has chemotactic activity for porcine, and in a lesser extent, for human neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (117 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
HMGB2High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor bindi [...] (210 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CCL19C-C motif chemokine. (100 aa)
CCL27C-C motif chemokine 27. (107 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (732 aa)
CXCR6Chemokine (C-X-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
CCR1Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
IL17RCIL17_R_N domain-containing protein. (511 aa)
ACKR4Chemokine (C-C motif) receptor-like protein 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
PLXNB3Plexin B3. (1894 aa)
AZU1Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin; Belongs to the peptidase S1 family. Elastase subfamily. (246 aa)
LOXProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
CXCL14SCY domain-containing protein. (110 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
CXCR5C-X-C chemokine receptor type 5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
F1SS05_PIGG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (160 aa)
CCL28C-C motif chemokine. (176 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (684 aa)
CCR7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa)
CCL3L1C-C motif chemokine. (126 aa)
CCL1C-C motif chemokine. (94 aa)
CCL11C-C motif chemokine. (97 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
LBPUncharacterized protein. (586 aa)
DPEP1Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa)
BIN2Bridging integrator 2. (512 aa)
CCL17C-C motif chemokine. (102 aa)
I3L9Z6_PIGUncharacterized protein. (335 aa)
CX3CR1CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1186 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1538 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
GPRL15Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). (81 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (379 aa)
CCR2C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. (373 aa)
DEFB1-2Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (64 aa)
XCR1Chemokine XC receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1574 aa)
F1RSX1_PIGUncharacterized protein. (200 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (222 aa)
CXCR3C-X-C chemokine receptor type 3 isoform 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
GAB1GRB2 associated binding protein 1. (723 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (835 aa)
CCL20C-C motif chemokine. (153 aa)
SLAMF1Ig-like domain-containing protein. (379 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
ALOX5Arachidonate 5-lipoxygenase. (638 aa)
LOC100737180C-X-C motif chemokine 17. (119 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MSMPBeta-microseminoprotein. (156 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (202 aa)
CXCL10C-X-C motif chemokine. (104 aa)
CCL24SCY domain-containing protein. (183 aa)
CCL8C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
LOC100515857C-C motif chemokine. (132 aa)
CCR4C-C chemokine receptor type 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CXADRUncharacterized protein. (419 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (492 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
A0A286ZVM6_PIGUncharacterized protein. (36 aa)
CKLFChemokine like factor. (113 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7. (410 aa)
LOC100516039C-C motif chemokine. (243 aa)
LGALS3Galectin. (271 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
CNR2Cannabinoid receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
ARRB2Arrestin beta 2. (493 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
CCR10G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
CCL16C-C motif chemokine. (120 aa)
CH25HCholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25- hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory eleme [...] (311 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
CCL26C-C motif chemokine. (94 aa)
LOC110257049Uncharacterized protein. (79 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1977 aa)
A0A287BIH2_PIGUncharacterized protein. (62 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
CXCL16C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). (342 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa)
CCL14C-C motif chemokine. (99 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2055 aa)
EGR3Early growth response protein 3 isoform 1. (387 aa)
PLECPlectin. (5422 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (496 aa)
TAFA4TAFA chemokine like family member 4. (140 aa)
RHOGUncharacterized protein. (394 aa)
JAMLJunction adhesion molecule like. (410 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
CXCL2C-X-C motif chemokine. (107 aa)
A0A287AYR7_PIGBeta-defensin 109-like. (134 aa)
GAS6Uncharacterized protein. (682 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1213 aa)
A0A287ATC1_PIGUncharacterized protein. (134 aa)
LOC100514068Uncharacterized protein. (257 aa)
CXCL9C-X-C motif chemokine. (126 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (766 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1 isoform 2. (598 aa)
SLC12A2Solute carrier family 12 member 2. (1186 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
SCG2Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. (616 aa)
CXCL13C-X-C motif chemokine. (111 aa)
CSF3RGranulocyte colony-stimulating factor receptor. (848 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (8%) [HD]