15 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	YTHDF3	YTH domain-containing family protein 3 isoform b. (588 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (755 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (447 aa)
	ADAR	Adenosine deaminase RNA specific. (1169 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (600 aa)
	TTLL12	Tubulin tyrosine ligase like 12. (604 aa)
	STAT2	Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
	DCST1	DC-STAMP domain containing 1. (707 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	METTL3	N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family. (580 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (305 aa)
	NLRC5	NLR family CARD domain containing 5. (1846 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7 isoform 1. (285 aa)
	ISG15	Ubiquitin-like modifier. (167 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	ISG15	ENSSSCP00000062912	ENSSSCP00000041015	Adenosine deaminase RNA specific.	Ubiquitin-like modifier.	0.510
ADAR	SAMHD1	ENSSSCP00000062912	ENSSSCP00000023070	Adenosine deaminase RNA specific.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.498
CACTIN	TTLL12	ENSSSCP00000056347	ENSSSCP00000068598	Cactin, spliceosome C complex subunit.	Tubulin tyrosine ligase like 12.	0.492
CNOT7	YTHDF2	ENSSSCP00000039703	ENSSSCP00000065604	CCR4-NOT transcription complex subunit 7 isoform 1.	YTH N6-methyladenosine RNA binding protein 2.	0.583
CNOT7	YTHDF3	ENSSSCP00000039703	ENSSSCP00000048507	CCR4-NOT transcription complex subunit 7 isoform 1.	YTH domain-containing family protein 3 isoform b.	0.640
ISG15	ADAR	ENSSSCP00000041015	ENSSSCP00000062912	Ubiquitin-like modifier.	Adenosine deaminase RNA specific.	0.510
ISG15	SAMHD1	ENSSSCP00000041015	ENSSSCP00000023070	Ubiquitin-like modifier.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.574
ISG15	STAT2	ENSSSCP00000041015	ENSSSCP00000069374	Ubiquitin-like modifier.	Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...]	0.851
METTL3	YTHDF2	ENSSSCP00000023249	ENSSSCP00000065604	N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family.	YTH N6-methyladenosine RNA binding protein 2.	0.845
METTL3	YTHDF3	ENSSSCP00000023249	ENSSSCP00000048507	N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family.	YTH domain-containing family protein 3 isoform b.	0.843
PTPN2	STAT2	ENSSSCP00000058148	ENSSSCP00000069374	Tyrosine-protein phosphatase non-receptor type.	Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...]	0.922
SAMHD1	ADAR	ENSSSCP00000023070	ENSSSCP00000062912	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	Adenosine deaminase RNA specific.	0.498
SAMHD1	ISG15	ENSSSCP00000023070	ENSSSCP00000041015	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	Ubiquitin-like modifier.	0.574
SAMHD1	TREX1	ENSSSCP00000023070	ENSSSCP00000019230	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	Three prime repair exonuclease 1.	0.658
STAT2	ISG15	ENSSSCP00000069374	ENSSSCP00000041015	Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...]	Ubiquitin-like modifier.	0.851
STAT2	PTPN2	ENSSSCP00000069374	ENSSSCP00000058148	Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...]	Tyrosine-protein phosphatase non-receptor type.	0.922
TREX1	SAMHD1	ENSSSCP00000019230	ENSSSCP00000023070	Three prime repair exonuclease 1.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.658
TTLL12	CACTIN	ENSSSCP00000068598	ENSSSCP00000056347	Tubulin tyrosine ligase like 12.	Cactin, spliceosome C complex subunit.	0.492
YTHDF2	CNOT7	ENSSSCP00000065604	ENSSSCP00000039703	YTH N6-methyladenosine RNA binding protein 2.	CCR4-NOT transcription complex subunit 7 isoform 1.	0.583
YTHDF2	METTL3	ENSSSCP00000065604	ENSSSCP00000023249	YTH N6-methyladenosine RNA binding protein 2.	N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family.	0.845