STRINGSTRING
NAB2 NAB2 BMP4 BMP4 EXT1 EXT1 LOC100517735 LOC100517735 EXT2 EXT2 COMP COMP MEF2C MEF2C SCUBE2 SCUBE2 MMP13 MMP13 IHH IHH HOXA11 HOXA11 ANXA6 ANXA6 SOX9 SOX9 MATN1 MATN1 IFT80 IFT80 I3L7W9_PIG I3L7W9_PIG SHOX2 SHOX2 NPPC NPPC MMP14 MMP14 BMPR1B BMPR1B ZMPSTE24 ZMPSTE24 FGF18 FGF18 GNAS GNAS RARG RARG COL3A1 COL3A1 SERPINH1 SERPINH1 RARA RARA COL2A1 COL2A1 TRIP11 TRIP11 IMPAD1 IMPAD1 MEF2D MEF2D DLX5 DLX5 THBS3 THBS3 MMP16 MMP16 PEX7 PEX7 CBS CBS CSGALNACT1 CSGALNACT1 SMPD3 SMPD3 A0A287AXH2_PIG A0A287AXH2_PIG SCX SCX ATF2 ATF2 AXIN2 AXIN2 BMP6 BMP6 ALPL ALPL A0A5G2RMB4_PIG A0A5G2RMB4_PIG A0A5G2QET8_PIG A0A5G2QET8_PIG TRPV4 TRPV4 A0A5G2RF62_PIG A0A5G2RF62_PIG COL1A1 COL1A1 PHOSPHO2 PHOSPHO2 ENSSSCP00000069602 ENSSSCP00000069602 A0A5G2QZ07_PIG A0A5G2QZ07_PIG RUNX2 RUNX2 A0A5G2R4X1_PIG A0A5G2R4X1_PIG PHOSPHO1 PHOSPHO1 ENSSSCP00000073689 ENSSSCP00000073689 COL13A1 COL13A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NAB2NGFI-A binding protein 2. (525 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
LOC100517735Hexosyltransferase. (384 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (688 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
SCUBE2CUB domain-containing protein. (539 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
ANXA6Annexin. (672 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
MATN1Matrilin 1. (496 aa)
IFT80Intraflagellar transport 80. (767 aa)
I3L7W9_PIGUncharacterized protein. (373 aa)
SHOX2Short stature homeobox 2. (321 aa)
NPPCC-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (126 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
GNASGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (1045 aa)
RARGRetinoic acid receptor gamma. (554 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
SERPINH1SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
TRIP11Thyroid hormone receptor interactor 11. (1974 aa)
IMPAD1Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] (359 aa)
MEF2DMyocyte enhancer factor 2D. (531 aa)
DLX5Homeobox protein DLX-5. (290 aa)
THBS3Thrombospondin-3 isoform 1. (973 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
PEX7Peroxisomal biogenesis factor 7. (308 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (611 aa)
CSGALNACT1Hexosyltransferase. (525 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
A0A287AXH2_PIGUncharacterized protein. (284 aa)
SCXBasic helix-loop-helix transcription factor scleraxis. (310 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
AXIN2Axin-2. (843 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
ALPLAlkaline phosphatase. (834 aa)
A0A5G2RMB4_PIGGRIP domain-containing protein. (469 aa)
A0A5G2QET8_PIGGRIP domain-containing protein. (461 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (924 aa)
A0A5G2RF62_PIGUncharacterized protein. (97 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
PHOSPHO2Pyridoxal phosphate phosphatase PHOSPHO2. (241 aa)
ENSSSCP00000069602annotation not available (97 aa)
A0A5G2QZ07_PIGGRIP domain-containing protein. (469 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
A0A5G2R4X1_PIGUncharacterized protein. (88 aa)
PHOSPHO1Uncharacterized protein. (465 aa)
ENSSSCP00000073689annotation not available (469 aa)
COL13A1Collagen type XIII alpha 1 chain. (726 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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