STRINGSTRING
SMAD6 SMAD6 SMAD4 SMAD4 SMAD7 SMAD7 BMP8B BMP8B GDF3 GDF3 INHBE INHBE GDF11 GDF11 ACVRL1 ACVRL1 BMP8A BMP8A TGFB1 TGFB1 ENG ENG CSNK2B CSNK2B BMP3 BMP3 PIN1 PIN1 GDF5 GDF5 INHA INHA GDF7 GDF7 LEFTY2 LEFTY2 MSTN MSTN GDF1 GDF1 LOC100524517 LOC100524517 SDCBP SDCBP BMPR2 BMPR2 BMPER BMPER TWSG1 TWSG1 EMILIN1 EMILIN1 RBPMS RBPMS INHBB INHBB HFE HFE GDF6 GDF6 BMP6 BMP6 NOG NOG PMEPA1 PMEPA1 INHBA INHBA LDLRAD4 LDLRAD4 NODAL NODAL DAB2 DAB2 BMPR1A BMPR1A BMP10 BMP10 ACVR2A ACVR2A GREM1 GREM1 BMP5 BMP5 BMP2 BMP2 TGFB2 TGFB2 GDF15 GDF15 INHBC INHBC TGFBR1 TGFBR1 TGFB3 TGFB3 GDF10 GDF10 GDF2 GDF2 BMP7 BMP7 BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD6Mothers against decapentaplegic homolog. (496 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
BMP8BTGF_BETA_2 domain-containing protein. (401 aa)
GDF3Growth differentiation factor 3. (363 aa)
INHBEInhibin subunit beta E. (350 aa)
GDF11Growth/differentiation factor 11 preproprotein. (404 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
BMP8ATGF_BETA_2 domain-containing protein. (360 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
CSNK2BCasein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (298 aa)
BMP3TGF_BETA_2 domain-containing protein. (719 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
GDF5Growth differentiation factor 5. (499 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (364 aa)
GDF7Growth differentiation factor 7. (449 aa)
LEFTY2Left-right determination factor. (366 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
GDF1Uncharacterized protein. (363 aa)
LOC100524517Left-right determination factor. (373 aa)
SDCBPSyndecan binding protein. (300 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
BMPERBMP binding endothelial regulator. (699 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (291 aa)
EMILIN1Elastin microfibril interfacer 1. (1292 aa)
RBPMSRNA binding protein, mRNA processing factor. (223 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (407 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (395 aa)
GDF6Growth/differentiation factor 6 preproprotein. (459 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (288 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (321 aa)
NODALNodal growth differentiation factor. (316 aa)
DAB2DAB adaptor protein 2. (769 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP10Bone morphogenetic protein 10 preproprotein. (423 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
GDF15Growth differentiation factor 15. (308 aa)
INHBCInhibin beta C chain preproprotein. (354 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
GDF10Growth differentiation factor 10. (480 aa)
GDF2Growth differentiation factor 2. (427 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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