STRINGSTRING
EGLN1 EGLN1 TBX5 TBX5 TBX3 TBX3 NSD2 NSD2 BMP7 BMP7 DHRS3 DHRS3 GATA6 GATA6 CITED2 CITED2 HEY2 HEY2 SMAD7 SMAD7 SMAD4 SMAD4 SMAD6 SMAD6 BMP4 BMP4 ZFPM2 ZFPM2 CHD7 CHD7 NOTCH2 NOTCH2 RBM15 RBM15 JAG1 JAG1 BMPR2 BMPR2 CCN1 CCN1 FGF8 FGF8 PARVA PARVA DNAH11 DNAH11 NOG NOG PROX1 PROX1 TP53 TP53 NRP2 NRP2 NOTCH1 NOTCH1 ZFPM1 ZFPM1 LRP2 LRP2 NOS3 NOS3 HES1 HES1 FZD2 FZD2 NKX2-5 NKX2-5 HAND1 HAND1 APLNR APLNR BMPR1A BMPR1A WNT5A WNT5A HEYL HEYL SAV1 SAV1 TGFBR1 TGFBR1 ENG ENG GATA4 GATA4 SEMA3C SEMA3C TBX2 TBX2 WNT11 WNT11 MKS1 MKS1 SLIT3 SLIT3 ISL1 ISL1 TBX20 TBX20 SMO SMO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGLN1Uncharacterized protein. (427 aa)
TBX5T-box transcription factor 5. (535 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
NSD2Histone-lysine N-methyltransferase NSD2 isoform 1. (1338 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ZFPM2Uncharacterized protein. (1153 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2863 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
RBM15RNA binding motif protein 15. (1006 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
CCN1Cellular communication network factor 1. (382 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PARVAParvin alpha. (373 aa)
DNAH11Dynein axonemal heavy chain 11. (4525 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PROX1Prospero homeobox 1. (737 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (920 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
ZFPM1Zinc finger protein, FOG family member 1. (965 aa)
LRP2Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hyp [...] (4626 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa)
HES1Uncharacterized protein. (280 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
NKX2-5NK2 homeobox 5. (323 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa)
SAV1Salvador family WW domain containing protein 1. (433 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
GATA4Transcription factor GATA-4 isoform 2. (442 aa)
SEMA3CSemaphorin-3C isoform 2; Belongs to the semaphorin family. (751 aa)
TBX2T-box 2 protein. (714 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
MKS1MKS transition zone complex subunit 1. (557 aa)
SLIT3Slit guidance ligand 3. (1523 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
TBX20T-box transcription factor TBX20 isoform 1. (449 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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