(12 nodes) Atrial septum morphogenesis network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
	NSD2	Histone-lysine N-methyltransferase NSD2 isoform 1. (1338 aa)
	TBX5	T-box transcription factor 5. (535 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	TBX20	T-box transcription factor TBX20 isoform 1. (449 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	GATA4	Transcription factor GATA-4 isoform 2. (442 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	ZFPM1	Zinc finger protein, FOG family member 1. (965 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA4	HEY2	ENSSSCP00000027951	ENSSSCP00000004561	Transcription factor GATA-4 isoform 2.	Hes related family bHLH transcription factor with YRPW motif 2.	0.516
GATA4	ISL1	ENSSSCP00000027951	ENSSSCP00000017891	Transcription factor GATA-4 isoform 2.	Insulin gene enhancer protein ISL-1.	0.726
GATA4	NKX2-5	ENSSSCP00000027951	ENSSSCP00000041789	Transcription factor GATA-4 isoform 2.	NK2 homeobox 5.	0.969
GATA4	TBX20	ENSSSCP00000027951	ENSSSCP00000017651	Transcription factor GATA-4 isoform 2.	T-box transcription factor TBX20 isoform 1.	0.838
GATA4	TBX5	ENSSSCP00000027951	ENSSSCP00000010532	Transcription factor GATA-4 isoform 2.	T-box transcription factor 5.	0.948
GATA4	ZFPM1	ENSSSCP00000027951	ENSSSCP00000049549	Transcription factor GATA-4 isoform 2.	Zinc finger protein, FOG family member 1.	0.708
HEY2	GATA4	ENSSSCP00000004561	ENSSSCP00000027951	Hes related family bHLH transcription factor with YRPW motif 2.	Transcription factor GATA-4 isoform 2.	0.516
HEY2	NOTCH2	ENSSSCP00000004561	ENSSSCP00000007154	Hes related family bHLH transcription factor with YRPW motif 2.	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein.	0.593
ISL1	GATA4	ENSSSCP00000017891	ENSSSCP00000027951	Insulin gene enhancer protein ISL-1.	Transcription factor GATA-4 isoform 2.	0.726
ISL1	NKX2-5	ENSSSCP00000017891	ENSSSCP00000041789	Insulin gene enhancer protein ISL-1.	NK2 homeobox 5.	0.751
ISL1	TBX20	ENSSSCP00000017891	ENSSSCP00000017651	Insulin gene enhancer protein ISL-1.	T-box transcription factor TBX20 isoform 1.	0.644
ISL1	TBX5	ENSSSCP00000017891	ENSSSCP00000010532	Insulin gene enhancer protein ISL-1.	T-box transcription factor 5.	0.780
NKX2-5	GATA4	ENSSSCP00000041789	ENSSSCP00000027951	NK2 homeobox 5.	Transcription factor GATA-4 isoform 2.	0.969
NKX2-5	ISL1	ENSSSCP00000041789	ENSSSCP00000017891	NK2 homeobox 5.	Insulin gene enhancer protein ISL-1.	0.751
NKX2-5	NSD2	ENSSSCP00000041789	ENSSSCP00000009255	NK2 homeobox 5.	Histone-lysine N-methyltransferase NSD2 isoform 1.	0.456
NKX2-5	TBX20	ENSSSCP00000041789	ENSSSCP00000017651	NK2 homeobox 5.	T-box transcription factor TBX20 isoform 1.	0.753
NKX2-5	TBX5	ENSSSCP00000041789	ENSSSCP00000010532	NK2 homeobox 5.	T-box transcription factor 5.	0.984
NOTCH2	HEY2	ENSSSCP00000007154	ENSSSCP00000004561	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein.	Hes related family bHLH transcription factor with YRPW motif 2.	0.593
NSD2	NKX2-5	ENSSSCP00000009255	ENSSSCP00000041789	Histone-lysine N-methyltransferase NSD2 isoform 1.	NK2 homeobox 5.	0.456
TBX20	GATA4	ENSSSCP00000017651	ENSSSCP00000027951	T-box transcription factor TBX20 isoform 1.	Transcription factor GATA-4 isoform 2.	0.838