(14 nodes) Trachea development network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
	CTNNB1	Catenin beta 1. (808 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (389 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	HOXA5	Homeobox domain-containing protein. (381 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SRF	Serum response factor. (512 aa)
	LEF1	Lymphoid enhancer binding factor 1. (429 aa)
	RARG	Retinoic acid receptor gamma. (554 aa)
	RARA	Retinoic acid receptor alpha isoform X1. (462 aa)
	FOXF1	Forkhead box protein F1. (423 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSSSCP00000005423	ENSSSCP00000031836	Bone morphogenetic protein 4.	Catenin beta 1.	0.604
BMP4	LEF1	ENSSSCP00000005423	ENSSSCP00000033976	Bone morphogenetic protein 4.	Lymphoid enhancer binding factor 1.	0.660
BMP4	SHH	ENSSSCP00000005423	ENSSSCP00000017394	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.850
BMP4	SOX9	ENSSSCP00000005423	ENSSSCP00000018278	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.698
CTNNB1	BMP4	ENSSSCP00000031836	ENSSSCP00000005423	Catenin beta 1.	Bone morphogenetic protein 4.	0.604
CTNNB1	LEF1	ENSSSCP00000031836	ENSSSCP00000033976	Catenin beta 1.	Lymphoid enhancer binding factor 1.	0.999
CTNNB1	MAPK1	ENSSSCP00000031836	ENSSSCP00000073842	Catenin beta 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.481
CTNNB1	MAPK3	ENSSSCP00000031836	ENSSSCP00000057520	Catenin beta 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.461
CTNNB1	SHH	ENSSSCP00000031836	ENSSSCP00000017394	Catenin beta 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.621
CTNNB1	SOX9	ENSSSCP00000031836	ENSSSCP00000018278	Catenin beta 1.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.918
FOXF1	SOX9	ENSSSCP00000042203	ENSSSCP00000018278	Forkhead box protein F1.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.443
FOXF1	SRF	ENSSSCP00000042203	ENSSSCP00000001805	Forkhead box protein F1.	Serum response factor.	0.529
LEF1	BMP4	ENSSSCP00000033976	ENSSSCP00000005423	Lymphoid enhancer binding factor 1.	Bone morphogenetic protein 4.	0.660
LEF1	CTNNB1	ENSSSCP00000033976	ENSSSCP00000031836	Lymphoid enhancer binding factor 1.	Catenin beta 1.	0.999
LEF1	SHH	ENSSSCP00000033976	ENSSSCP00000017394	Lymphoid enhancer binding factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.721
LEF1	SOX9	ENSSSCP00000033976	ENSSSCP00000018278	Lymphoid enhancer binding factor 1.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.632
MAP2K1	MAPK1	ENSSSCP00000056482	ENSSSCP00000073842	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.975
MAP2K1	MAPK3	ENSSSCP00000056482	ENSSSCP00000057520	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.959
MAPK1	CTNNB1	ENSSSCP00000073842	ENSSSCP00000031836	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Catenin beta 1.	0.481
MAPK1	MAP2K1	ENSSSCP00000073842	ENSSSCP00000056482	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.975