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| | CCBE1 | Collagen and calcium binding EGF domains 1. (407 aa) |
| | TBX4 | Uncharacterized protein. (549 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | SIM2 | Single-minded homolog 2 long isoform. (673 aa) |
| | CCDC40 | Coiled-coil domain containing 40. (986 aa) |
| | ADAMTS2 | ADAM metallopeptidase with thrombospondin type 1 motif 2. (1204 aa) |
| | HS6ST1 | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa) |
| | TBX2 | T-box 2 protein. (714 aa) |
| | ADAMTSL2 | ADAMTS like 2. (958 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | SLC23A1 | Solute carrier family 23 member 1 isoform a. (605 aa) |
| | PHF14 | PHD finger protein 14. (953 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (779 aa) |
| | MMP14 | Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa) |
| | IGFBP5 | Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (271 aa) |
| | HESX1 | HESX homeobox 1. (185 aa) |
| | I3LLG5_PIG | Uncharacterized protein. (131 aa) |
| | GNG8 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa) |
| | RCN3 | Reticulocalbin 3. (335 aa) |
| | HIKESHI | Heat shock protein nuclear import factor hikeshi. (197 aa) |
| | AIMP2 | Uncharacterized protein. (319 aa) |
| | DNAJC22 | DnaJ heat shock protein family (Hsp40) member C22. (351 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | TULP3 | TUB like protein 3; Belongs to the TUB family. (472 aa) |
| | BAG6 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1163 aa) |
| | PTK7 | Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa) |
| | SRF | Serum response factor. (512 aa) |
| | CTSH | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (335 aa) |
| | CYP1A2 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa) |
| | STRA6 | Stimulated by retinoic acid 6. (666 aa) |
| | NKX2-8 | NK2 homeobox 8. (241 aa) |
| | DNAAF1 | Dynein assembly factor 1, axonemal. (650 aa) |
| | PDPN | Uncharacterized protein. (159 aa) |
| | GATA6 | Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | SIX1 | Six homeobox 1. (284 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | AARD | Alanine and arginine rich domain containing protein. (153 aa) |
| | ZFPM2 | Uncharacterized protein. (1153 aa) |
| | MSC | Musculin. (201 aa) |
| | CRH | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. (191 aa) |
| | CHD7 | Chromodomain helicase DNA binding protein 7. (2863 aa) |
| | MAN1A2 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (677 aa) |
| | ASXL1 | ASXL transcriptional regulator 1. (1542 aa) |
| | CTSZ | Cathepsin Z; Belongs to the peptidase C1 family. (304 aa) |
| | EPAS1 | Uncharacterized protein. (870 aa) |
| | PKDCC | Protein kinase domain containing, cytoplasmic. (493 aa) |
| | SEC24B | SEC24 homolog B, COPII coat complex component. (1258 aa) |
| | TBX5 | T-box transcription factor 5. (535 aa) |
| | LIPA | Lipase A, lysosomal acid type. (450 aa) |
| | CCDC39 | Coiled-coil domain-containing protein 39. (942 aa) |
| | ZIC3 | Zic family member 3. (467 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | RAB3A | Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa) |
| | LOX | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa) |
| | HSD11B1 | Corticosteroid 11-beta-dehydrogenase isozyme 1. (292 aa) |
| | SP3 | Sp3 transcription factor. (789 aa) |
| | HSPB11 | Heat shock protein family B (small) member 11. (157 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (527 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | SELENON | Selenoprotein N. (556 aa) |
| | MAN2A1 | Alpha-mannosidase. (1164 aa) |
| | DLG5 | Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa) |
| | GRHL2 | Grainyhead like transcription factor 2. (626 aa) |
| | ADA | Adenosine deaminase. (409 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |
| | SPRY1 | Sprouty RTK signaling antagonist 1. (319 aa) |
| | MYOCD | Myocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa) |
| | ACVR2B | Activin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa) |
| | LOXL3 | Lysyl oxidase like 3. (814 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | A0A5G2R752_PIG | DUF775 domain-containing protein. (196 aa) |
| | RBBP9 | RB binding protein 9, serine hydrolase. (238 aa) |
| | PLOD3 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (744 aa) |
| | PKD1 | Polycystin 1, transient receptor potential channel interacting. (4383 aa) |
| | PPP3R1 | Uncharacterized protein. (188 aa) |
| | FGF9 | Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa) |
| | JMJD6 | Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (413 aa) |
| | CELSR1 | Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3320 aa) |
| | PHOX2B | Paired like homeobox 2B. (314 aa) |
| | SFTPD | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. (386 aa) |
| | THRB | Thyroid hormone receptor beta isoform X2. (476 aa) |
| | ABCA12 | ATP binding cassette subfamily A member 12. (2593 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | GLI1 | Zinc finger protein GLI1 isoform X1. (1106 aa) |
| | RC3H2 | Ring finger and CCCH-type domains 2. (1192 aa) |
| | CHI3L1 | Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (427 aa) |
| | LTBP3 | Latent transforming growth factor beta binding protein 3. (1332 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
| | NKX2-1 | NK2 homeobox 1. (399 aa) |
| | NPHP3 | TPR_REGION domain-containing protein. (1368 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | HHIP | Hedgehog-interacting protein. (700 aa) |
| | TCF21 | Transcription factor 21. (179 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | KLF2 | Kruppel-like factor 2. (357 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa) |
| | ATXN1L | Ataxin 1 like. (688 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | SPDEF | SAM pointed domain containing ETS transcription factor. (363 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (656 aa) |
| | NODAL | Nodal growth differentiation factor. (316 aa) |
| | HES1 | Uncharacterized protein. (280 aa) |
| | CIC | Capicua transcriptional repressor. (2520 aa) |
| | FNDC3B | Fibronectin type III domain containing 3B. (1178 aa) |
| | AGR2 | Anterior gradient 2, protein disulphide isomerase family member. (206 aa) |
| | DLX5 | Homeobox protein DLX-5. (290 aa) |
| | FOXA1 | Forkhead box A1. (468 aa) |
| | FOXF1 | Forkhead box protein F1. (423 aa) |
| | DISP1 | Dispatched RND transporter family member 1. (1590 aa) |
| | NKIRAS1 | NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | ERRFI1 | ERBB receptor feedback inhibitor 1. (461 aa) |
| | EDN2 | Endothelin 2. (180 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | FGF1 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa) |
| | CCN2 | CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa) |
| | LIF | Leukemia inhibitory factor isoform X1. (202 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | ESRP2 | Epithelial splicing regulatory protein 2. (717 aa) |
| | TMEM38B | Trimeric intracellular cation channel type B. (290 aa) |
| | RARA | Retinoic acid receptor alpha isoform X1. (462 aa) |
| | SIX4 | Homeobox domain-containing protein. (785 aa) |
| | RDH10 | Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa) |
| | STK40 | Serine/threonine-protein kinase 40 isoform 2. (435 aa) |
| | RXFP1 | Relaxin family peptide receptor 1. (785 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (429 aa) |
| | COL3A1 | Collagen alpha-1(III) chain preproprotein. (1471 aa) |
| | YAP1 | Yes associated protein 1. (432 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) |
| | RARG | Retinoic acid receptor gamma. (554 aa) |
| | RPGRIP1L | Protein fantom isoform X1. (1270 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | SAV1 | Salvador family WW domain containing protein 1. (433 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | GPC3 | Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (389 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (604 aa) |
| | ITGA3 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa) |
| | SLC7A11 | Solute carrier family 7 member 11. (515 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | HOXA5 | Homeobox domain-containing protein. (381 aa) |
| | GLI3 | GLI family zinc finger 3. (1586 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | FOXJ1 | Forkhead box J1. (421 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa) |
| | TTC25 | Tetratricopeptide repeat domain 25. (685 aa) |
| | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a. (191 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa) |
| | WT1 | Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa) |
