(13 nodes) Morphogenesis of an epithelial fold network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NODAL	Nodal growth differentiation factor. (316 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform 1. (824 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SOSTDC1	Sclerostin domain containing 1. (229 aa)
	BMP7	Bone morphogenetic protein 7. (650 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa)
	HOXD13	Homeobox protein Hox-D13. (341 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	GDF7	Growth differentiation factor 7. (449 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	CECR2	CECR2 histone acetyl-lysine reader. (1291 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	HIF1A	ENSSSCP00000013166	ENSSSCP00000050717	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Hypoxia-inducible factor 1-alpha isoform 1.	0.553
BMP4	BMP7	ENSSSCP00000005423	ENSSSCP00000007993	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.842
BMP4	FGF10	ENSSSCP00000005423	ENSSSCP00000017886	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.880
BMP4	NOG	ENSSSCP00000005423	ENSSSCP00000053671	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998
BMP7	BMP4	ENSSSCP00000007993	ENSSSCP00000005423	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.842
BMP7	FGF10	ENSSSCP00000007993	ENSSSCP00000017886	Bone morphogenetic protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.607
BMP7	GDF7	ENSSSCP00000007993	ENSSSCP00000021254	Bone morphogenetic protein 7.	Growth differentiation factor 7.	0.443
BMP7	NOG	ENSSSCP00000007993	ENSSSCP00000053671	Bone morphogenetic protein 7.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.955
FGF10	BMP4	ENSSSCP00000017886	ENSSSCP00000005423	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.880
FGF10	BMP7	ENSSSCP00000017886	ENSSSCP00000007993	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 7.	0.607
FGF10	HIF1A	ENSSSCP00000017886	ENSSSCP00000050717	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hypoxia-inducible factor 1-alpha isoform 1.	0.463
FGF10	NOG	ENSSSCP00000017886	ENSSSCP00000053671	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.838
GDF7	BMP7	ENSSSCP00000021254	ENSSSCP00000007993	Growth differentiation factor 7.	Bone morphogenetic protein 7.	0.443
GDF7	NOG	ENSSSCP00000021254	ENSSSCP00000053671	Growth differentiation factor 7.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.954
HIF1A	AR	ENSSSCP00000050717	ENSSSCP00000013166	Hypoxia-inducible factor 1-alpha isoform 1.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.553
HIF1A	FGF10	ENSSSCP00000050717	ENSSSCP00000017886	Hypoxia-inducible factor 1-alpha isoform 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.463
NOG	BMP4	ENSSSCP00000053671	ENSSSCP00000005423	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Bone morphogenetic protein 4.	0.998
NOG	BMP7	ENSSSCP00000053671	ENSSSCP00000007993	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Bone morphogenetic protein 7.	0.955
NOG	FGF10	ENSSSCP00000053671	ENSSSCP00000017886	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.838
NOG	GDF7	ENSSSCP00000053671	ENSSSCP00000021254	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Growth differentiation factor 7.	0.954