STRINGSTRING
RSPO3 RSPO3 ADM ADM IL10 IL10 FZD5 FZD5 GRB2 GRB2 SPINT1 SPINT1 GCM1 GCM1 ST14 ST14 SOCS3 SOCS3 GRHL2 GRHL2 SPINT2 SPINT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RSPO3Uncharacterized protein. (280 aa)
ADMProadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. (188 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (531 aa)
GCM1Glial cells missing transcription factor 1. (431 aa)
ST14Suppressor of tumorigenicity 14 protein. (856 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
GRHL2Grainyhead like transcription factor 2. (626 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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