STRINGSTRING
TRIM44 TRIM44 C1QTNF4 C1QTNF4 IRAK1 IRAK1 USP27X USP27X SH2B3 SH2B3 STAP1 STAP1 TXK TXK SLIT2 SLIT2 OTOP1 OTOP1 IL1R2 IL1R2 ZBP1 ZBP1 MAVS MAVS GFI1 GFI1 HIPK1 HIPK1 SHARPIN SHARPIN TRAF2 TRAF2 TRIM32 TRIM32 PALM3 PALM3 BIRC7-2 BIRC7-2 NLRP6 NLRP6 DCST1 DCST1 STAT2 STAT2 TTLL12 TTLL12 TLR2 TLR2 IL1R1 IL1R1 ROBO1 ROBO1 LSM14A LSM14A OTULIN OTULIN YTHDF2 YTHDF2 RABGEF1 RABGEF1 IL7 IL7 TAF9 TAF9 NR1H4 NR1H4 ADAR ADAR PRKN PRKN PELI3 PELI3 RIPK1 RIPK1 CXCR4 CXCR4 CSF1 CSF1 PTPN2 PTPN2 CACTIN CACTIN BIRC7 BIRC7 TRIM56 TRIM56 RFFL RFFL PARP9 PARP9 HIF1A HIF1A CD74 CD74 CDC37 CDC37 NOL3 NOL3 CD300LF CD300LF LRRC70 LRRC70 GAS6 GAS6 PYCARD PYCARD YTHDF3 YTHDF3 SPATA2 SPATA2 UBE2K UBE2K ADIPOQ ADIPOQ TBK1 TBK1 DDX58 DDX58 IFIH1 IFIH1 MAPK7 MAPK7 EDN1 EDN1 IRAK2 IRAK2 CYLD CYLD PIAS4 PIAS4 ISG15 ISG15 AXL AXL PTPRC PTPRC NKIRAS1 NKIRAS1 CNOT7 CNOT7 XIAP XIAP WNT5A WNT5A TREM2 TREM2 TICAM2 TICAM2 TNFRSF1A TNFRSF1A PAFAH1B1 PAFAH1B1 NLRC5 NLRC5 OTUD4 OTUD4 APOA1 APOA1 SYK SYK VRK2 VRK2 CAV1 CAV1 FADD FADD DHX9 DHX9 IRF3 IRF3 TRIM6 TRIM6 RIPK2 RIPK2 PADI2 PADI2 TRAIP TRAIP SOCS1 SOCS1 MUL1 MUL1 METTL3 METTL3 SAMHD1 SAMHD1 SIGIRR SIGIRR ECM1 ECM1 IKBKE IKBKE TREX1 TREX1 MED1 MED1 NKIRAS2 NKIRAS2 SPHK1 SPHK1 SLIT3 SLIT3 LOC100522887 LOC100522887 HPX HPX STING1 STING1 F2RL1 F2RL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIM44Tripartite motif containing 44. (355 aa)
C1QTNF4C1q domain-containing protein. (94 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (691 aa)
USP27XUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)
SH2B3SH2B adaptor protein 3. (600 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
TXKTyrosine-protein kinase. (551 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
OTOP1Otopetrin 1. (612 aa)
IL1R2Interleukin 1 receptor type 2. (413 aa)
ZBP1Uncharacterized protein. (438 aa)
MAVSMitochondrial antiviral signaling protein. (532 aa)
GFI1Growth factor independent 1 transcriptional repressor. (416 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform 1. (1210 aa)
SHARPINSHANK associated RH domain interactor. (400 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
TRIM32Tripartite motif containing 32. (652 aa)
PALM3Paralemmin 3. (747 aa)
BIRC7-2Uncharacterized protein. (428 aa)
NLRP6NLR family pyrin domain containing 6. (891 aa)
DCST1DC-STAMP domain containing 1. (707 aa)
STAT2Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
TTLL12Tubulin tyrosine ligase like 12. (604 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
IL1R1Interleukin-1 receptor type 1 isoform 1. (572 aa)
ROBO1Roundabout guidance receptor 1. (1687 aa)
LSM14AUncharacterized protein. (475 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (352 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
RABGEF1Uncharacterized protein. (503 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation; Belongs to the IL-7/IL-9 family. (176 aa)
TAF9Transcription initiation factor TFIID subunit 9. (265 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (509 aa)
ADARAdenosine deaminase RNA specific. (1169 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (668 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
CSF1Colony stimulating factor 1. (656 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (447 aa)
CACTINCactin, spliceosome C complex subunit. (755 aa)
BIRC7RING-type domain-containing protein. (151 aa)
TRIM56Tripartite motif containing 56. (755 aa)
RFFLUncharacterized protein. (799 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (847 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
CD74Thyroglobulin type-1 domain-containing protein. (347 aa)
CDC37CDC37 cell division cycle 37 protein. (380 aa)
NOL3Nucleolar protein 3. (237 aa)
CD300LFIg-like domain-containing protein. (301 aa)
LRRC70Leucine-rich repeat-containing protein 70. (631 aa)
GAS6Uncharacterized protein. (682 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (196 aa)
YTHDF3YTH domain-containing family protein 3 isoform b. (588 aa)
SPATA2Spermatogenesis-associated protein 2. (520 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
ADIPOQC1q domain-containing protein. (332 aa)
TBK1TANK binding kinase TBK1. (729 aa)
DDX58Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)
IFIH1Interferon induced with helicase C domain 1. (1023 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (840 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (621 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (955 aa)
PIAS4Protein inhibitor of activated STAT 4. (566 aa)
ISG15Ubiquitin-like modifier. (167 aa)
AXLUncharacterized protein. (871 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa)
CNOT7CCR4-NOT transcription complex subunit 7 isoform 1. (285 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TREM2Ig-like domain-containing protein. (248 aa)
TICAM2TIR domain-containing adapter molecule 2. (237 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
NLRC5NLR family CARD domain containing 5. (1846 aa)
OTUD4OTU deubiquitinase 4. (1110 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
VRK2Serine/threonine-protein kinase VRK2. (507 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
DHX9ATP-dependent RNA helicase A. (1384 aa)
IRF3Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
TRIM6Tripartite motif containing 6. (487 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
PADI2Peptidyl arginine deiminase 2. (689 aa)
TRAIPE3 ubiquitin-protein ligase TRAIP. (471 aa)
SOCS1Suppressor of cytokine signaling 1. (220 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (305 aa)
METTL3N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family. (580 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
SIGIRRUncharacterized protein. (410 aa)
ECM1Extracellular matrix protein 1. (559 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (718 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a. (191 aa)
SPHK1Sphingosine kinase 1 isoform 2. (481 aa)
SLIT3Slit guidance ligand 3. (1523 aa)
LOC100522887Uncharacterized protein; Belongs to the peptidase C14A family. (376 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (459 aa)
STING1Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa)
F2RL1Proteinase-activated receptor 2 preproprotein. (397 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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