STRINGSTRING
COL3A1 COL3A1 NDST1 NDST1 DCTN5 DCTN5 TGFBR1 TGFBR1 ENG ENG TAB1 TAB1 HOXA13 HOXA13 TBX2 TBX2 WNT11 WNT11 NF1 NF1 NGFR NGFR ADAMTS6 ADAMTS6 GLI3 GLI3 SHH SHH LOX LOX COMP COMP SUFU SUFU ZMIZ1 ZMIZ1 EGR2 EGR2 HPGD HPGD PKD2 PKD2 SRF SRF ADGRF5 ADGRF5 STRA6 STRA6 HECTD1 HECTD1 APOE APOE ANGPTL3 ANGPTL3 CITED2 CITED2 HEY2 HEY2 SMAD7 SMAD7 SMAD6 SMAD6 BMP4 BMP4 SIX1 SIX1 FOXH1 FOXH1 CHD7 CHD7 JAG1 JAG1 NPRL3 NPRL3 EDNRA EDNRA SEC24B SEC24B ACVRL1 ACVRL1 BMPR2 BMPR2 FKBP10 FKBP10 LDLR LDLR PLXND1 PLXND1 MYOCD MYOCD ACVR2B ACVR2B FGF8 FGF8 NKX3-1 NKX3-1 PRDM1 PRDM1 HAND2 HAND2 LEP LEP DLL4 DLL4 NOG NOG PROX1 PROX1 NOTCH1 NOTCH1 A0A287B1R4_PIG A0A287B1R4_PIG LRP2 LRP2 SLC2A10 SLC2A10 HES1 HES1 DDIT3 DDIT3 PRICKLE1 PRICKLE1 EDN1 EDN1 APOB APOB FOXF1 FOXF1 APLNR APLNR MYLK MYLK BMPR1A BMPR1A TFAP2B TFAP2B ARID2 ARID2 EYA1 EYA1 PRRX1 PRRX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
NDST1Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2. (882 aa)
DCTN5Dynactin subunit 5. (182 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (604 aa)
HOXA13Homeobox A13. (388 aa)
TBX2T-box 2 protein. (714 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
NF1Neurofibromin 1. (2847 aa)
NGFRNerve growth factor receptor. (414 aa)
ADAMTS6A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1. (1117 aa)
GLI3GLI family zinc finger 3. (1586 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
LOXProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
SUFUSUFU negative regulator of hedgehog signaling. (432 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1065 aa)
EGR2E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
HPGD15-hydroxyprostaglandin dehydrogenase NAD(+) isoform 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
SRFSerum response factor. (512 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1340 aa)
STRA6Stimulated by retinoic acid 6. (666 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2139 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (461 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SIX1Six homeobox 1. (284 aa)
FOXH1Forkhead box H1. (354 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2863 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (611 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1258 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
FKBP10Peptidylprolyl isomerase. (576 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
PLXND1Plexin D1. (1926 aa)
MYOCDMyocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform 1. (247 aa)
PRDM1PR/SET domain 1. (842 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PROX1Prospero homeobox 1. (737 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
A0A287B1R4_PIGUncharacterized protein. (34 aa)
LRP2Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hyp [...] (4626 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (540 aa)
HES1Uncharacterized protein. (280 aa)
DDIT3DNA-damage-inducible transcript 3. (167 aa)
PRICKLE1Prickle planar cell polarity protein 1. (856 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
APOBApolipoprotein B-100. (4573 aa)
FOXF1Forkhead box protein F1. (423 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
MYLKMyosin light chain kinase, smooth muscle; Phosphorylates a specific serine in the N-terminus of a myosin light chain. Also regulates actin-myosin interaction through a non-kinase activity (By similarity). (1981 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
ARID2AT-rich interaction domain 2. (1833 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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