STRINGSTRING
CTNNB1 CTNNB1 RARG RARG SMAD1 SMAD1 ZBTB16 ZBTB16 ZNF219 ZNF219 SMAD3 SMAD3 RUNX2 RUNX2 CCN1 CCN1 PTPN11 PTPN11 LNPK LNPK LTBP3 LTBP3 GDF6 GDF6 AXIN2 AXIN2 NOG NOG CHADL CHADL SCX SCX CCN4 CCN4 SMPD3 SMPD3 EFEMP1 EFEMP1 RFLNB RFLNB PTHLH PTHLH LOXL2 LOXL2 FRZB FRZB SOX6 SOX6 SCIN SCIN BMP10 BMP10 RFLNA RFLNA GREM1 GREM1 WNT5A WNT5A SNAI2 SNAI2 CCN2 CCN2 BMP2 BMP2 NKX3-2 NKX3-2 RARA RARA SOX5 SOX5 ADAMTS7 ADAMTS7 SMAD7 SMAD7 BMP4 BMP4 SIX2 SIX2 PKDCC PKDCC BMP1 BMP1 GDF2 GDF2 IHH IHH HOXA11 HOXA11 GLI3 GLI3 SOX9 SOX9 KAT2A KAT2A SHOX2 SHOX2 GDF5 GDF5 BMPR1B BMPR1B GLG1 GLG1 ADAMTS12 ADAMTS12 FGF18 FGF18 TGFB1 TGFB1 TGFBR1 TGFBR1 MAF MAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin beta 1. (808 aa)
RARGRetinoic acid receptor gamma. (554 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ZNF219Zinc finger protein 219. (716 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
CCN1Cellular communication network factor 1. (382 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LNPKLunapark, ER junction formation factor. (429 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
GDF6Growth/differentiation factor 6 preproprotein. (459 aa)
AXIN2Axin-2. (843 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CHADLChondroadherin like. (760 aa)
SCXBasic helix-loop-helix transcription factor scleraxis. (310 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (512 aa)
RFLNBRefilin-B. (219 aa)
PTHLHParathyroid hormone like hormone. (209 aa)
LOXL2Lysyl oxidase like 2. (758 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
SOX6SRY-box transcription factor 6. (859 aa)
SCINAdseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (715 aa)
BMP10Bone morphogenetic protein 10 preproprotein. (423 aa)
RFLNAUncharacterized protein. (266 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
CCN2CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
NKX3-2NK3 homeobox 2. (337 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
SOX5SRY-box transcription factor 5. (763 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1660 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SIX2SIX homeobox 2. (296 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
BMP1Metalloendopeptidase. (987 aa)
GDF2Growth differentiation factor 2. (427 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
GLI3GLI family zinc finger 3. (1586 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
KAT2ALysine acetyltransferase 2A. (857 aa)
SHOX2Short stature homeobox 2. (321 aa)
GDF5Growth differentiation factor 5. (499 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GLG1Golgi glycoprotein 1. (1210 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (408 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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