STRINGSTRING
WNT1 WNT1 TIMELESS TIMELESS SRF SRF PKHD1 PKHD1 CTSH CTSH PML PML PLEKHH1 PLEKHH1 EPHA2 EPHA2 CSMD2 CSMD2 GREB1L GREB1L TIE1 TIE1 SMAD4 SMAD4 BMP4 BMP4 SIX1 SIX1 NRARP NRARP EXT1 EXT1 RBM15 RBM15 GZF1 GZF1 BMP7 BMP7 CTSZ CTSZ SLIT2 SLIT2 AREG AREG SFRP2 SFRP2 EDNRA EDNRA PKD2 PKD2 TBX3 TBX3 GDF2 GDF2 KDM5B KDM5B AR AR LRP5 LRP5 ADM ADM TMEM59L TMEM59L SEMA3E SEMA3E IL10 IL10 CSMD1 CSMD1 HOXD13 HOXD13 FZD5 FZD5 IHH IHH GBX2 GBX2 SHH SHH MET MET TBX20 TBX20 HOXA11 HOXA11 HOXA5 HOXA5 GLI3 GLI3 FGF10 FGF10 ADAMTS16 ADAMTS16 GRB2 GRB2 SOX9 SOX9 MED1 MED1 HOXB13 HOXB13 MKS1 MKS1 CCL11 CCL11 WT1 WT1 FEM1B FEM1B ILK ILK TBX2 TBX2 GDF7 GDF7 SEMA3C SEMA3C KRAS KRAS GREB1 GREB1 MMP14 MMP14 RASIP1 RASIP1 PHB2 PHB2 HOXA13 HOXA13 DCHS1 DCHS1 PTCH1 PTCH1 EGF EGF KDR KDR SFRP1 SFRP1 SRC SRC GPC3 GPC3 ENG ENG TGFB1 TGFB1 PAK1 PAK1 ESR1 ESR1 DLG1 DLG1 DDR1 DDR1 PAX2 PAX2 LHX1 LHX1 CTNNB1 CTNNB1 RSPO3 RSPO3 PPP1CA PPP1CA YAP1 YAP1 LEF1 LEF1 SOX8 SOX8 RDH10 RDH10 GCM1 GCM1 SOX10 SOX10 ESRP2 ESRP2 BMP2 BMP2 FGF1 FGF1 WNT5A WNT5A EYA1 EYA1 PLXNA1 PLXNA1 HS3ST3A1 HS3ST3A1 GNA13 GNA13 CLIC4 CLIC4 CTNNBIP1 CTNNBIP1 FOXF1 FOXF1 FOXA1 FOXA1 EDN1 EDN1 GDNF GDNF ST14 ST14 NOTCH1 NOTCH1 SOCS3 SOCS3 PROX1 PROX1 TCF21 TCF21 FRS2 FRS2 HHIP HHIP NOG NOG SPINT1 SPINT1 NKX2-1 NKX2-1 DLL4 DLL4 FGF2 FGF2 SPINT2 SPINT2 VDR VDR WNT9B WNT9B NKX3-1 NKX3-1 CITED1 CITED1 CSF1 CSF1 WNT6 WNT6 CELSR1 CELSR1 PPP3R1 PPP3R1 A0A5G2QUL4_PIG A0A5G2QUL4_PIG DLG2 DLG2 PKD1 PKD1 BTRC BTRC TP63 TP63 TGM2 TGM2 FGF8 FGF8 NFATC4 NFATC4 SPRY1 SPRY1 PLXND1 PLXND1 SPRY2 SPRY2 GRHL2 GRHL2 DLG5 DLG5 STK4 STK4 BTBD7 BTBD7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
SRFSerum response factor. (512 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4075 aa)
CTSHCathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (335 aa)
PMLPromyelocytic leukemia. (827 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1354 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
CSMD2Uncharacterized protein. (1106 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1909 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SIX1Six homeobox 1. (284 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
RBM15RNA binding motif protein 15. (1006 aa)
GZF1Uncharacterized protein. (235 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (304 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
AREGAmphiregulin long form. (247 aa)
SFRP2Uncharacterized protein. (294 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
GDF2Growth differentiation factor 2. (427 aa)
KDM5BLysine-specific demethylase 5B isoform 2. (1547 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
ADMProadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. (188 aa)
TMEM59LTransmembrane protein 59-like. (349 aa)
SEMA3ESemaphorin-3E isoform 1; Belongs to the semaphorin family. (775 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa)
CSMD1CUB and Sushi multiple domains 1. (3258 aa)
HOXD13Homeobox protein Hox-D13. (341 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
TBX20T-box transcription factor TBX20 isoform 1. (449 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
HOXA5Homeobox domain-containing protein. (381 aa)
GLI3GLI family zinc finger 3. (1586 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1202 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
HOXB13Homeobox B13. (285 aa)
MKS1MKS transition zone complex subunit 1. (557 aa)
CCL11C-C motif chemokine. (97 aa)
WT1Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa)
FEM1BProtein fem-1 homolog B. (627 aa)
ILKIntegrin linked kinase. (479 aa)
TBX2T-box 2 protein. (714 aa)
GDF7Growth differentiation factor 7. (449 aa)
SEMA3CSemaphorin-3C isoform 2; Belongs to the semaphorin family. (751 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GREB1Uncharacterized protein. (1970 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
RASIP1Ras interacting protein 1. (967 aa)
PHB2Prohibitin. (299 aa)
HOXA13Homeobox A13. (388 aa)
DCHS1Dachsous cadherin-related 1. (3294 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SRCTyrosine-protein kinase. (559 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
DDR1Tyrosine-protein kinase receptor. (1005 aa)
PAX2Paired box 2. (416 aa)
LHX1LIM homeobox 1. (436 aa)
CTNNB1Catenin beta 1. (808 aa)
RSPO3Uncharacterized protein. (280 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
YAP1Yes associated protein 1. (432 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
SOX8SRY-box transcription factor 8. (460 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
GCM1Glial cells missing transcription factor 1. (431 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
FGF1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
PLXNA1Plexin A1. (1909 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (405 aa)
GNA13G protein subunit alpha 13. (377 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
FOXF1Forkhead box protein F1. (423 aa)
FOXA1Forkhead box A1. (468 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
GDNFGlial cell line-derived neurotrophic factor isoform 1. (211 aa)
ST14Suppressor of tumorigenicity 14 protein. (856 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PROX1Prospero homeobox 1. (737 aa)
TCF21Transcription factor 21. (179 aa)
FRS2Fibroblast growth factor receptor substrate 2. (550 aa)
HHIPHedgehog-interacting protein. (700 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (531 aa)
NKX2-1NK2 homeobox 1. (399 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
VDRVitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform 1. (247 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
CSF1Colony stimulating factor 1. (656 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3320 aa)
PPP3R1Uncharacterized protein. (188 aa)
A0A5G2QUL4_PIGUncharacterized protein. (536 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4383 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (603 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
TGM2Transglutaminase 2. (696 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NFATC4Nuclear factor of activated T cells 4. (937 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
PLXND1Plexin D1. (1926 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
GRHL2Grainyhead like transcription factor 2. (626 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)
STK4Serine/threonine kinase 4. (502 aa)
BTBD7BTB domain containing 7. (1129 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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